Results 11 to 20 of about 21,268 (171)

SERPINE1 Alternative Polyadenylation Influences Gastric Cancer Prognosis via N6-Methyladenosine Modification. [PDF]

Cancer Sci
Multi‐omics integration of the transcriptomic APA landscape and m6A modifications identifies key prognostic genes. Their biological functions and molecular mechanisms in promoting tumor progression are comprehensively validated through in vitro assays. ABSTRACT Alternative polyadenylation (APA) and N6‐methyladenosine (m6A) methylation are critical post‐
Wu Z, Xu R, Fang J, Liu B, Zhang C, Zhang S, Ni J.   +6 more
europepmc   +2 more sources

Correction to "IGF2BP3-Dependent N6-Methyladenosine Modification of USP49 Promotes Carboplatin Resistance in Retinoblastoma by Enhancing Autophagy via Regulating the Stabilization of SIRT1". [PDF]

Kaohsiung J Med Sci
The Kaohsiung Journal of Medical Sciences, EarlyView.
europepmc   +2 more sources

ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO-Mediated N6-Methyladenosine Demethylation of ACSL1 mRNA. [PDF]

Kaohsiung J Med Sci
ABSTRACT Microglia play an important role in ischemic stroke (IS). However, the molecular regulatory mechanisms underlying microglial ferroptosis in IS remain incompletely understood. In this study, blood samples were collected from 20 IS patients and 15 healthy volunteers.
Song AX, Jin HX, Sun YX, Kou WH, Niu XN, Wang HH, Zhong TT, Gu P.   +7 more
europepmc   +2 more sources

FTO plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review

Frontiers in Oncology, 2023
Gastrointestinal cancer is a common malignancy with high mortality and poor prognosis. Therefore, developing novel effective markers and therapeutic targets for gastrointestinal cancer is currently a challenging and popular topic in oncology research ...
Xiangqing Ren, Xiangqing Ren, Xiangqing Ren, Xiaolong Tang, Tian Huang, Tian Huang, Tian Huang, Zenan Hu, Zenan Hu, Yuping Wang, Yuping Wang, Yongning Zhou, Yongning Zhou   +12 more
doaj   +1 more source

ALKBH5 prevents hepatocellular carcinoma progression by post-transcriptional inhibition of PAQR4 in an m6A dependent manner

Experimental Hematology & Oncology, 2023
Background N6-methyladenosine (m6A) is a prevalent modification of mRNA and is known to play important roles in tumorigenesis in many types of cancer. The function of N6-methyladenosine (m6A) RNA methylation depends on a variety of methyltransferases and
Weijian Wang, Qibo Huang, Zhibin Liao, Hongwei Zhang, Yachong Liu, Furong Liu, Xiaoping Chen, Bixiang Zhang, Yan Chen, Peng Zhu   +9 more
doaj   +1 more source

Comprehensive Analysis of N6-methyladenosine Modification Patterns Associated With Multiomic Characteristics of Bladder Cancer

Frontiers in Medicine, 2021
Purpose: To comprehensively analyze N6-methyladenosine modification patterns in bladder tumors and to further systematically explore the inherent relationships between these modification patterns and multiomic tumor characteristics.Materials and Methods:
Jingchao Liu, Jingchao Liu, Jianlong Wang, Meng Wu, Wei Zhang, Wei Zhang, Lingfeng Meng, Lingfeng Meng, Jiawen Wang, Jiawen Wang, Zhengtong Lv, Zhengtong Lv, Haoran Xia, Haoran Xia, Yaoguang Zhang, Yaoguang Zhang, Jianye Wang, Jianye Wang   +17 more
doaj   +1 more source

Benchmark data for identifying N6-methyladenosine sites in the Saccharomyces cerevisiae genome

Data in Brief, 2015
This data article contains the benchmark dataset for training and testing iRNA-Methyl, a web-server predictor for identifying N6-methyladenosine sites in RNA (Chen et al., 2015 [15]).
Wei Chen, Pengmian Feng, Hui Ding, Hao Lin, Kuo-Chen Chou   +4 more
doaj   +1 more source

Roles and implications of mRNA N6‐methyladenosine in cancer

Cancer Communications, 2023
RNA N6‐methyladenosine modification is the most prevalent internal modification of eukaryotic RNAs and has emerged as a novel field of RNA epigenetics, garnering increased attention.
Lingxing Zeng, Xudong Huang, Jialiang Zhang, Dongxin Lin, Jian Zheng   +4 more
doaj   +1 more source

Liver-specific Mettl3 ablation delays liver regeneration in mice

Genes and Diseases, 2022
This study investigated the role of N6-methyladenosine RNA methylation in liver regeneration following partial hepatectomy in mice. We created a liver-specific knockout mouse model by the deletion of Mettl3, a key component of the N6-methyladenosine ...
Jiaxiang Meng, Zhicong Zhao, Zhifeng Xi, Qiang Xia   +3 more
doaj   +1 more source

UPLC-MS/MS method for simultaneously determining nucleosides and methyl-nucleosides in liver mRNA of Epimedin C-induced liver injury mouse model

Chinese Medicine, 2021
Background Epimedin C, one of the main active ingredients of Epimedium, has been reported to have potential hepatotoxicity. However, the mechanism of Epimedin C-induced liver injury has not been studied.
Zhizhen Song, Zeyun Li, Xueqian Wen, Ruijuan Liu, Xin Tian   +4 more
doaj   +1 more source