Results 11 to 20 of about 22,540 (229)

The implications of N6-methyladenosine (m6A) modification in esophageal carcinoma. [PDF]

Mol Biol Rep, 2023
AbstractEsophageal carcinoma (EC) is always diagnosed at advanced stage and its the mortality rate remains high. The patients usually miss the best opportunity for treatment because of non-specific symptoms and the survival rates are low. N6-methyladenosine (m6A) the predominant modification in eukaryotic messenger RNA(mRNA), serves vital roles in ...
He C, Teng X, Wang L, Ni M, Zhu L, Liu J, Lv W, Hu J.   +7 more
europepmc   +3 more sources

Editorial: Emerging roles of N6-methyladenosine (m6A) modifications in endocrine disorders. [PDF]

Front Endocrinol (Lausanne), 2023
Bu P, Asadipooya K.
europepmc   +4 more sources

Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis. [PDF]

Front Cell Dev Biol, 2022
Osteoarthritis (OA) is the most common joint disease, usually occurring in middle-aged and elderly people. However, current treatment for OA in its early stages is ineffective, and drug therapy is often ineffective in slowing the progression of the disease.
Zhai G, Xiao L, Jiang C, Yue S, Zhang M, Zheng J, Liu Z, Dong Y.   +7 more
europepmc   +4 more sources

Potential roles of N6-methyladenosine (m6A) in immune cells [PDF]

Journal of Translational Medicine, 2021
AbstractN6-methyl-adenosine (m6A) is one of the most common internal modifications on RNA molecules present in mammalian cells. Deregulation of m6A modification has been recently implicated in many types of human diseases. Therefore, m6A modification has become a research hotspot for its potential therapeutic applications in the treatment of various ...
Chang Liu, Zhe Yang, Rong Li, Yanju Wu, Ming Chi, Shuting Gao, Xun Sun, Xin Meng, Biao Wang   +8 more
openaire   +3 more sources

Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology [PDF]

Toxicological Sciences, 2021
Abstract Epitranscriptomics, the study of chemically modified RNAs, is a burgeoning field being explored in a variety of scientific disciplines. Of the currently known epitranscriptomic modifications, N6-methyladenosine (m6A) methylation is the most abundant.
Malovic, Emir, Ealy, Alyssa, Kanthasamy, Arthi, Kanthasamy, Anumantha G   +3 more
openaire   +2 more sources

N6-Methyladenosine (m6A) Modification in Natural Immune Cell-Mediated Inflammatory Diseases. [PDF]

J Innate Immun, 2023
The post-transcriptional N6-methyladenosine (m6A) modification of RNA influences stability, transport, and translation with implications for various physiological and pathological processes. Immune cell development, differentiation, and activation are also thought to be regulated by m6A and affect host defense against pathogens and inflammatory ...
Teng Y, Yi J, Chen J, Yang L.
europepmc   +4 more sources

Regulatory Role of N6-methyladenosine (m6A) Modification in Osteosarcoma [PDF]

Frontiers in Oncology, 2021
Osteosarcoma is the most common primary bone malignancy, typically occurring in childhood or adolescence. Unfortunately, the clinical outcomes of patients with osteosarcoma are usually poor because of the aggressive nature of this disease and few treatment advances in the past four decades. N6-methyladenosine (m6A) is one of the most extensive forms of
Yujie Zhang, Yanyan Wang, Liwei Ying, Sifeng Tao, Mingmin Shi, Peng Lin, Yangxin Wang, Bin Han   +7 more
openaire   +3 more sources

The role of N6-methyladenosine (m⁶A) in kidney diseases. [PDF]

Front Med (Lausanne), 2023
Chemical modifications are a specific and efficient way to regulate the function of biological macromolecules. Among them, RNA molecules exhibit a variety of modifications that play important regulatory roles in various biological processes. More than 170 modifications have been identified in RNA molecules, among which the most common internal ...
You L, Han Z, Chen H, Chen L, Lin Y, Wang B, Fan Y, Zhang M, Luo J, Peng F, Ma Y, Wang Y, Yuan L, Han Z.   +13 more
europepmc   +4 more sources

The therapeutic targets of N6-methyladenosine (m6A) modifications on tumor radioresistance. [PDF]

Discov Oncol, 2023
AbstractRadiation therapy is an important tool for malignant tumors, and its tolerance needs to be addressed. In recent years, several studies have shown that regulators of aberrant m6A methylation play an important role in the formation, development and invasion and metastasis of tumors.
Zhang Y, Gu W, Shao Y.
europepmc   +4 more sources

Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma

Annals of Hepatology, 2021
N6-methyladenosine (m6A) is the most thoroughly studied type of internal RNA modification, as this epigenetic modification is the most abundant in eukaryotic RNAs to date. This modification occurs in various types of RNAs and plays significant roles in dominant RNA-related processes, such as translation, splicing, export and degradation.
Yue-fan Wang, Chun-mei Ge, Hao-zan Yin, Zhi-hui Dai, Jun-peng Dong, Man Ji, Fu Yang   +6 more
openaire   +3 more sources