Results 21 to 30 of about 22,540 (229)

N6-methyladenosine (m6A) RNA modification in cancer stem cells [PDF]

Stem Cells, 2020
Abstract Cancer stem cells (CSCs), a unique subset of undifferentiated cells with stem cell-like properties, have emerged as driving forces in mediating tumor growth, metastasis, and therapeutic resistance. Recent advances have highlighted that N6-methyladenosine (m6A) RNA modification plays an important role in cancer biology and CSCs ...
Zhonghua Ma, Jiafu Ji
openaire   +2 more sources

N6-methyladenosine (m6A) RNA modification in fibrosis and collagen-related diseases. [PDF]

Clin Epigenetics
Fibrosis is an abnormal tissue healing process characterized by the excessive accumulation of ECM components, such as COL I and COL III, in response to tissue injury or chronic inflammation. Recent advances in epitranscriptomics have underscored the importance of m6A modification in fibrosis.
Tan M, Liu S, Liu L.
europepmc   +4 more sources

Influence of N6-methyladenosine (m6A) modification on cell phenotype in Alzheimer's disease. [PDF]

PLoS One, 2023
ObjectiveRecent research has suggested that m6A modification takes on critical significance to Neurodegeneration. As indicated by the genome-wide map of m6A mRNA, genes in Alzheimer’s disease model achieved significant m6A methylation. This study aimed to investigate the hub gene and pathway of m6A modification in the pathogenesis of AD.
Ni P, Pan K, Zhao B.
europepmc   +3 more sources

Impact of N6-methyladenosine (m6A) modification on immunity

Cell Communication and Signaling, 2022
AbstractN6-methyl-adenosine (m6A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m6A relies on m6A writers, erasers and readers. m6A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels.
Raghda A. Elsabbagh, Mona Rady, Carsten Watzl, Khaled Abou-Aisha, Mohamed Z. Gad   +4 more
openaire   +4 more sources

N6-methyladenosine (m6A) modification and its clinical relevance in cognitive dysfunctions [PDF]

Aging, 2021
N6 adenosine methylation (m6A) is the most abundant internal RNA modification in eukaryotic cells. Dysregulation of m6A has been associated with the perturbations of cell proliferation and cell death in different diseases. However, the roles of m6A in the neurodegenerative process and cognitive dysfunction are unclear.We systematically investigated the
Du, Bingying, Zhang, Yanbo, Liang, Meng, Du, Zengkan, Li, Haibo, Fan, Cunxiu, Zhang, Hailing, Jiang, Yan, Bi, Xiaoying   +8 more
openaire   +2 more sources

N6-methyladenosine (m6A) regulatory gene divides hepatocellular carcinoma into three subtypes [PDF]

Journal of Gastrointestinal Oncology, 2021
The N6-methyladenosine (m6A) plays an important role in epigenetic modification and tumor progression, but the modulations of m6A in hepatocellular carcinoma (HCC) have not been determined while the relationship between m6A regulation and immune cell infiltration remains unclear.This study investigated the modification patterns of m6A by analyzing HCC ...
Jie, Wei, Da Lang, Fang, Weijie, Zhou, Yong Fei, He   +3 more
openaire   +2 more sources

METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m6A Modification

Molecular Therapy: Nucleic Acids, 2020
N6-Methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) that occurred on the N6 nitrogen of adenosine. However, the roles of m6A in oral squamous cell carcinoma (OSCC) are still elusive.
Wei Zhao, Yameng Cui, Lina Liu, Xiaozhou Ma, Xiaoqian Qi, Yue Wang, Zihao Liu, Shiqing Ma, Jingwen Liu, Jie Wu   +9 more
doaj   +1 more source

Systematic comparison of tools used for m6A mapping from nanopore direct RNA sequencing

Nature Communications, 2023
Direct RNA sequencing using nanopore platform can be used to detect N6-methyladenosine (m6A) modifications on mRNAs. Here the authors systematically compare tools used for m6A detection from nanopore direct sequencing.
Zhen-Dong Zhong, Ying-Yuan Xie, Hong-Xuan Chen, Ye-Lin Lan, Xue-Hong Liu, Jing-Yun Ji, Fu Wu, Lingmei Jin, Jiekai Chen, Daniel W. Mak, Zhang Zhang, Guan-Zheng Luo   +11 more
doaj   +1 more source

m6A-mRNA Methylation Regulates Gene Expression and Programmable m6A Modification of Cellular RNAs With CRISPR-Cas13b in Renal Cell Carcinoma

Frontiers in Genetics, 2022
Background: N6-methyladenosine (m6A) is the most extensive messenger RNA modification. Despite recent advances in the biological roles of m6A, its role in the development and progression of renal cell carcinoma (RCC) remains unclear.Methods: In this ...
Ying Gan, Ying Gan, Aolin Li, Aolin Li, Jun Liu, Jun Liu, Xiaofei Wang, Xiaofei Wang, Zhenan Zhang, Zhenan Zhang, Qinhan Li, Qinhan Li, Xiongjun Ye, Xiongjun Ye, Lin Yao, Lin Yao, Qian Zhang, Qian Zhang   +17 more
doaj   +1 more source

N6-methyladenosine (m6A) methylation in kidney diseases: Mechanisms and therapeutic potential

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2023
The N6-methyladenosine (m6A) modification is regulated by methylases, commonly referred to as "writers," and demethylases, known as "erasers," leading to a dynamic and reversible process. Changes in m6A levels have been implicated in a wide range of cellular processes, including nuclear RNA export, mRNA metabolism, protein translation, and RNA splicing,
Yuting, Sun, De, Jin, Ziwei, Zhang, Hangyu, Ji, Xuedong, An, Yuehong, Zhang, Cunqing, Yang, Wenjie, Sun, Yuqing, Zhang, Yingying, Duan, Xiaomin, Kang, Linlin, Jiang, Xuefei, Zhao, Fengmei, Lian   +13 more
openaire   +2 more sources