Results 41 to 50 of about 22,540 (229)

Insights into N6-methyladenosine (m6A) modification of noncoding RNA in tumor microenvironment. [PDF]

Aging (Albany NY), 2023
N6-methyladenosine (m6A) is the most abundant RNA modification in eukaryotes, and it participates in the regulation of pathophysiological processes in various diseases, including malignant tumors, by regulating the expression and function of both coding and non-coding RNAs (ncRNAs). More and more studies demonstrated that m6A modification regulates the
Zhang Y, Zhan L, Li J, Jiang X, Yin L.
europepmc   +3 more sources

Role of N6-Methyladenosine (m6A) Methylation Regulators in Hepatocellular Carcinoma [PDF]

Frontiers in Oncology, 2021
Liver cancer is the fifth most common malignant tumor in terms of incidence and the third leading cause of cancer-related mortality globally. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Although great progress has been made in surgical techniques, hepatic artery chemoembolization, molecular targeting and ...
Nanfang Qu, Xiaotong Bo, Bin Li, Lei Ma, Feng Wang, Qinghua Zheng, Xuhua Xiao, Fengmei Huang, Yuanyuan Shi, Xuemei Zhang   +9 more
openaire   +3 more sources

Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing

Nature Communications, 2020
Adenovirus transcripts contain N6-methyladenosine (m6A) modification. Here the authors profile m6A modification sites on adenovirus mRNAs using Illumina meRIP-Seq and nanopore direct RNA sequencing, and showcase a role for m6A in splicing of viral late ...
Alexander M. Price, Katharina E. Hayer, Alexa B. R. McIntyre, Nandan S. Gokhale, Jonathan S. Abebe, Ashley N. Della Fera, Christopher E. Mason, Stacy M. Horner, Angus C. Wilson, Daniel P. Depledge, Matthew D. Weitzman   +10 more
doaj   +1 more source

Structural and Virus Regulatory Insights Into Avian N6-Methyladenosine (m6A) Machinery [PDF]

Frontiers in Cell and Developmental Biology, 2020
The addition of a methyl group to the N6 position of adenosine (m6A) is the most common posttranscriptional RNA modification, and it regulates most steps of RNA metabolism including splicing, stability, translation, nuclear-export, and RNA structures. Besides cellular RNA, m6A modifications have also been detected on viral RNA.
Bayoumi, Mahmoud, Rohaim, Mohammed A, Munir, Muhammad   +2 more
openaire   +3 more sources

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d [PDF]

, 2018
N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotes, playing crucial roles in multiple biological processes. m6A is catalyzed by the activity of Mettl3, which depends on additional proteins whose precise functions remain poorly ...
Andrade-Navarro, Miguel A., Biggiogera, Marco, Bühler, Marc, Carl, Sarah H., Hares, Tina, Haussmann, Irmgard, Helm, Mark, Hess, Daniel, Jacob, Dominik, Knuckles, Philip, Kreim, Nastasja, Lence, Tina, Masiello, Irene, Roignant, Jean-Yves, Soller, Matthias, Villaseñor, Rodrigo   +15 more
core   +4 more sources

N 6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA

Nature Communications, 2021
N6-methyladenosine (m6A) RNA modification regulates RNA metabolism, and has been implicated in immune regulation. Here, the authors show that the m6A methyltransferase, METTL3, translocates into the cytoplasm to increase viral RNA m6A modification ...
Weinan Qiu, Qingyang Zhang, Rui Zhang, Yangxu Lu, Xin Wang, Huabin Tian, Ying Yang, Zijuan Gu, Yanan Gao, Xin Yang, Guanshen Cui, Baofa Sun, Yanan Peng, Hongyu Deng, Hua Peng, Angang Yang, Yun-Gui Yang, Pengyuan Yang   +17 more
doaj   +1 more source

Crosstalk between N6-methyladenosine (m6A) modification and noncoding RNA in tumor microenvironment. [PDF]

Int J Biol Sci, 2023
N6-methyladenosine (m6A) is the most abundant RNA modification in eukaryotes, and it participates in the regulation of pathophysiological processes in various diseases, including malignant tumors, by regulating the expression and function of both coding and non-coding RNAs (ncRNAs). More and more studies demonstrated that m6A modification regulates the
Wang D, Han Y, Peng L, Huang T, He X, Wang J, Ou C.   +6 more
europepmc   +3 more sources

Genome-Wide Location Analyses of N6-Methyladenosine Modifications (m6A-Seq) [PDF]

, 2017
N6-methyladenosine-sequencing (m6A-seq) is a critical tool to obtain an unbiased genome-wide picture of m6A sites of modification at high resolution. It allows the study of the impact of various perturbations on m6A modification distribution and the study of m6A functions. Herein, we describe the m6A-seq protocol, which entails RNA immunoprecipitation (
Benoit, Molinie, Cosmas C, Giallourakis
openaire   +2 more sources

Epitranscriptomics as a new layer of regulation of gene expression in skeletal muscle: known functions and future perspectives [PDF]

, 2023
Epitranscriptomics refers to post-transcriptional regulation of gene expression via RNA modifications and editing that affect RNA functions. Many kinds of modifications of mRNA have been described, among which are N6-methyladenosine (m6A), N1 ...
Alessandra Renzini, Carol Imbriano, Eleonora Maretti, Giorgia Cavioli, Silvia Belluti, Susanna Molinari, Viviana Moresi   +6 more
core   +1 more source

N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis [PDF]

Nature Structural & Molecular Biology, 2017
RNA modifications are integral to the regulation of RNA metabolism. One abundant mRNA modification is N6-methyladenosine (m6A), which affects various aspects of RNA metabolism, including splicing, translation and degradation. Current knowledge about the proteins recruited to m6A to carry out these molecular processes is still limited.
Raghu R Edupuganti, Simon Geiger, Rik G H Lindeboom, Hailing Shi, Phillip J Hsu, Zhike Lu, Shuang-Yin Wang, Marijke P A Baltissen, Pascal W T C Jansen, Martin Rossa, Markus Müller, Hendrik G Stunnenberg, Chuan He, Thomas Carell, Michiel Vermeulen   +14 more
openaire   +4 more sources