Results 1 to 10 of about 20,678 (180)

Assessment of [¹²⁵I]a-Bungarotoxin Binding to a7 Nicotinic Acetylcholinergic Receptors in Hippocampus-Subiculum of Postmortem Human Parkinson’s Disease Brain [PDF]

Biomolecules
Parkinson’s disease (PD) involves motor and cognitive impairment that nicotinic acetylcholine receptors (nAChRs) such as the α7 subtype are responsible for regulating.
Fariha Karim, Allyson Ngo, Titus E. Tucker, Ashlee D. L. Coronel, Jogeshwar Mukherjee   +4 more
doaj   +2 more sources

Universal nature of cholinergic regulation demonstrated with nicotinic acetylcholine receptors

BBA Advances, 2022
Mammalian nicotinic acetylcholine receptors (nAChRs) were initially discovered as ligand-gated ion channels mediating fast synaptic transmission in the neuro-muscular junctions and autonomic ganglia. They were further found to be involved in a wide range
Maryna Skok
doaj   +1 more source

Nicotinic Acetylcholine Receptors as Potential Tumor Biomarkers in Genitourinary Cancers: a Review Study [PDF]

ImmunoAnalysis, 2021
The genitourinary tissues express the different subtypes of nicotinic acetylcholine receptors (nAChRs), which are involved in many physiologic and pathologic processes.
Khalil Hajiasgharzadeh, Behzad Baradaran, Leili Aghebati Maleki, Alireza Khabbazi   +3 more
doaj   +1 more source

Alcohol and nicotinic acetylcholine receptors [PDF]

QScience Connect, 2013
Background The frequent co-abuse of alcohol and tobacco may suggest that they share some common neurological mechanisms. For example, nicotine acts on Nicotinic acetylcholine receptors (nAChRs) in the brain to release dopamine to sustain addiction. Might
Jinsong Tang, Yanhui Liao
doaj   +1 more source

Activation of α7-nAChRs Promotes the Clearance of α-Synuclein and Protects Against Apoptotic Cell Death Induced by Exogenous α-Synuclein Fibrils

Frontiers in Cell and Developmental Biology, 2021
Misfolding and abnormal aggregation of α-synuclein (αSyn) have been shown to increase the risk of developing Parkinson's disease (PD). Finding some way to reduce the aggregation of αSyn is particularly important for the treatment of PD. The main route in
Jifeng Zhao, Yun Li, Yan Li, Shi Xu, Tingting Tao, Ye Hua, Ji Zhang, Yi Fan   +7 more
doaj   +1 more source

Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis

Cell Death and Disease, 2021
Osteoarthritis (OA) is the most common chronic joint disease in the elderly population. Growing evidence indicates that a balance between autophagy and apoptosis in chondrocytes plays a key role in OA’s cartilage degradation.
Yuan Liu, Shi Xu, Haijun Zhang, Kaoliang Qian, Jiachen Huang, Xianger Gu, Yan Li, Yi Fan, Jun Hu   +8 more
doaj   +1 more source

Unique Pharmacological Properties of α-Conotoxin OmIA at α7 nAChRs

Frontiers in Pharmacology, 2021
OmIA, isolated from Conus omaria venom, is a potent antagonist at α7 nAChRs. We determined the co-crystal structure of OmIA with Lymnae stagnalis acetylcholine binding protein (Ls-AChBP) that identified His5, Val10 and Asn11 as key determinants for the ...
Thao N.T. Ho, Nikita Abraham, Richard J. Lewis   +2 more
doaj   +1 more source

Resistance to Inhibitors of Cholinesterase 3 (Ric-3) Expression Promotes Selective Protein Associations with the Human α7-Nicotinic Acetylcholine Receptor Interactome. [PDF]

PLoS ONE, 2015
The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel widely expressed in vertebrates and is associated with numerous physiological functions.
Matthew J Mulcahy, Sydney B Blattman, Francisco J Barrantes, Ronald J Lukas, Edward Hawrot   +4 more
doaj   +1 more source

Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors

Pharmacological Research, 2023
Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in both the peripheral and the central nervous systems. nAChRs exert a crucial modulatory influence on several brain biological processes; they are involved in a variety of ...
Federica Bono, Chiara Fiorentini, Veronica Mutti, Zaira Tomasoni, Giulia Sbrini, Hanna Trebesova, Mario Marchi, Massimo Grilli, Cristina Missale   +8 more
doaj   +1 more source

Axonal α7* nicotinic acetylcholine receptors modulate glutamatergic signaling and synaptic vesicle organization in ventral hippocampal projections

Frontiers in Neural Circuits, 2022
Modulation of the release of glutamate by activation of presynaptic nicotinic acetylcholine receptors (nAChRs) is one of the most prevalent mechanism of nicotinic facilitation of glutamatergic transmission in cortico-limbic circuits.
Chongbo Zhong, Wendy Akmentin, Lorna W. Role, David A. Talmage   +3 more
doaj   +1 more source