Results 11 to 20 of about 20,678 (180)

Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells. [PDF]

PLoS ONE, 2016
In addition to the T2R bitter taste receptors, neuronal nicotinic acetylcholine receptors (nAChRs) have recently been shown to be involved in the bitter taste transduction of nicotine, acetylcholine and ethanol.
Jie Qian, Shobha K Mummalaneni, Reem M Alkahtani, Sunila Mahavadi, Karnam S Murthy, John R Grider, Vijay Lyall   +6 more
doaj   +14 more sources

(−)-Adaline from the Adalia Genus of Ladybirds Is a Potent Antagonist of Insect and Specific Mammalian Nicotinic Acetylcholine Receptors

Molecules, 2022
Ladybird beetles (Coleoptera: Coccinellidae) possess strong chemical defences that are secreted in response to stress and are also found on the coating of eggs, which are rich in alkaloids that are responsible for their toxicity to other species.
David P. Richards, Rohit N. Patel, Ian R. Duce, Bhupinder P. S. Khambay, Michael A. Birkett, John A. Pickett, Ian R. Mellor   +6 more
doaj   +1 more source

Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior [PDF]

, 2003
Prenatal nicotine exposure has been linked to attention deficit hyperactivity disorder and cognitive impairment, but the sites of action for these effects of nicotine are still under investigation. High-affinity nicotinic acetylcholine receptors (nAChRs)
Caldarone, Barbara J, Collins, Allan C, Grady, Sharon R, King, Sarah L, Koren, Andrei O, Marks, Michael J, Mukhin, Alexey G, Picciotto, Marina R   +7 more
core   +2 more sources

Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596.

PLoS ONE, 2010
BackgroundThe level of expression of functional α7-containing nicotinic acetylcholine receptors (nAChRs) in hippocampal CA1 pyramidal neurons is believed to be very low compared to hippocampal CA1 interneurons, and for many years this expression was ...
Bopanna I Kalappa, Alexander G Gusev, Victor V Uteshev   +2 more
doaj   +1 more source

A novel α-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between Rat α9α10 and α7 nicotinic cholinergic receptors [PDF]

, 2005
The α9 and α10 nicotinic cholinergic subunits assemble to form the receptor believed to mediate synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, one of the few examples of postsynaptic function for a non-muscle ...
Arredondo, Azam, Baker, Balestra, Bleckmann, Bobbin, Boulter, Cartier, Champtiaux, Chernyavsky, Colquhoun, Conroy, Couturier, Dawkins, Deneris, Drescher, Duvoisin, Elgoyhen, Elgoyhen, Engelmann, Flock, Fuchs, Genzen, Gerzanich, Gerzanich, Glowatzki, Goldman, Gotti, Gotti, Groot-Kormelink, Guinan, Haberberger, Jones, Karlin, Katz, Katz, Kros, Kurzen, Le Novere, Lips, Luebke, Lustig, McIntosh, McIntosh, Mihovilovic, Morley, Nguyen, Nicke, Peng, Pohlmann, Rothlin, Russell, Santos, Sato, Seguela, Sgard, Terlau, Walker, Wals, Weisstaub   +59 more
core   +1 more source

Nicotinic α7 acetylcholine receptor-mediated currents are not modulated by the tryptophan metabolite kynurenic acid in adult hippocampal interneurons [PDF]

, 2011
The  tryptophan  metabolite,  kynurenic  acid (KYNA),  is  classically  known  to  be  an antagonist  of ionotropic glutamate receptors.
Andrew L. Varnell, Donald C. Cooper, Kevin J. Staley, Peter Dobelis   +3 more
core   +3 more sources

Higher availability of α4β2 nicotinic receptors (nAChRs) in dorsal ACC is linked to more efficient interference control

NeuroImage, 2020
Nicotinic acetylcholine receptors (nAChRs) are widely distributed in the human brain and play an important role in the neuromodulation of brain networks implicated in attentional processes.
Swann Pichon, Valentina Garibotto, Michael Wissmeyer, Yann Seimbille, Lia Antico, Osman Ratib, Patrik Vuilleumier, Sven Haller, Fabienne Picard   +8 more
doaj   +1 more source

Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation

Pharmacological Research, 2023
Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated ion channels and function as such in the central and peripheral nervous systems. Recently, however, non-ionic signaling mechanisms via nAChRs have been demonstrated
Arik J. Hone, J. Michael McIntosh
doaj   +1 more source

Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]

, 2009
Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan, Chebib, Mary, Elgoyhen, Ana Belen, McIntosh, J. Michael, Vincler, Michelle   +4 more
core   +1 more source

Structure-Function Elucidation of a New α-Conotoxin, MilIA, from Conus milneedwardsi

Marine Drugs, 2019
The a-Conotoxins are peptide toxins that are found in the venom of marine cone snails and they are potent antagonists of various subtypes of nicotinic acetylcholine receptors (nAChRs).
Steve Peigneur, Prabha Devi, Andrea Seldeslachts, Samuthirapandian Ravichandran, Loïc Quinton, Jan Tytgat   +5 more
doaj   +1 more source