Results 11 to 20 of about 955,520 (208)

Timing of NAD Deficiency During Organogenesis Dictates Defect Type and Penetrance [PDF]

FASEB J
Pregnant mice on a vitamin B3‐free and tryptophan‐limited diet have embryos with Congenital NAD Deficiency Disorder, characterized by malformations and/or death. We longitudinally tracked the maternal NAD metabolome, embryo growth, and malformation occurrence. Mice with lower NAD Salvage Pathway metabolite levels and minimal levels of derived excretion
Bozon K, Cuny H, Sunn N, Martin E, Sheng D, Chapman G, Dunwoodie S.   +6 more
europepmc   +2 more sources

Nicotinamide riboside and caffeine partially restore diminished NAD availability but not altered energy metabolism in Alzheimer's disease

Aging Cell, Volume 21, Issue 7, July 2022., 2022
Nicotinamide riboside (NR) and caffeine increase nicotinamide adenine dinucleotide (NAD), transiently modulate bioenergetic functions, and change the expression of NAD‐synthesizing, recycling, or degrading genes in dermal fibroblasts or induced pluripotent stem cell (iPSC)‐derived neural progenitors and astrocytes from late‐onset Alzheimer's disease ...
Woo‐In Ryu, Minqi Shen, Yoon Lee, Ryan A. Healy, Mariana K. Bormann, Bruce M. Cohen, Kai‐Christian Sonntag   +6 more
wiley   +1 more source

CD38 Drives Progress of Osteoarthritis by Affecting Cartilage Homeostasis

Orthopaedic Surgery, Volume 14, Issue 5, Page 946-954, May 2022., 2022
CD38 is a membrane‐bound protein. This study primarily implicates CD38 as an important regulator of chondrogenic differentiation. Inhibition of CD38 demonstrated protection against cartilage degeneration, which suggests that CD38 could be a potential therapeutic target for OA.
Jin‐jin Ma, Jun Ying, Jin‐yu Wang, Tao‐tao Xu, Han‐ting Xia, Hong‐ting Jin, Lu‐wei Xiao, Wen‐jun Shang, Wei‐qian Wang, Jian‐yin Feng   +9 more
wiley   +1 more source

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging

Aging Cell, Volume 21, Issue 4, April 2022., 2022
The NADase CD38 plays a key role in age‐related NAD decline. The CD38 inhibitor 78c increases lifespan and healthspan of naturally aged male mice. The increase in median and maximal lifespan was about 10%. Abstract Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction.
Thais R. Peclat, Katie L. Thompson, Gina M. Warner, Claudia C.S. Chini, Mariana G. Tarragó, Delaram Z. Mazdeh, Chunlian Zhang, Jose Zavala‐Solorio, Ganesh Kolumam, Yao Liang Wong, Robert L. Cohen, Eduardo N. Chini   +11 more
wiley   +1 more source

Crystal structure of a short‐chain dehydrogenase/reductase from Burkholderia phymatum in complex with NAD

Acta Crystallographica Section F, Volume 78, Issue 2, Page 52-58, February 2022., 2022
The crystal structure of a short‐chain dehydrogenase/reductase from Burkholderia phymatum offers insights into its possible functions and likely inhibitors of its enzymatic functions.Burkholderia phymatum is an important symbiotic nitrogen‐fixing betaproteobacterium. B.
Jawaher Alenazi, Stephen Mayclin, Sandhya Subramanian, Peter J. Myler, Oluwatoyin A. Asojo   +4 more
wiley   +1 more source

Nicotinamide pathways as the root cause of sepsis – an evolutionary perspective on macrophage energetic shifts

The FEBS Journal, Volume 289, Issue 4, Page 955-964, February 2022., 2022
Increased IDO activity towards de novo nicotinamide synthesis is a hallmark of alternatively activated macrophages. IDO upregulation in alternatively activated macrophages may be an attempt to compensate for insufficient NAD availability. Manipulation of nicotinamide metabolism may shift macrophage metabolism, thereby providing a therapeutic approach ...
Melinda S. Suchard, Dana M. Savulescu
wiley   +1 more source

Structural and catalytic characterization of Blastochloris viridis and Pseudomonas aeruginosa homospermidine synthases supports the essential role of cation–π interaction

Acta Crystallographica Section D, Volume 77, Issue 10, Page 1317-1335, October 2021., 2021
The homospermidine synthases from P. aeruginosa and B. viridis, as well as their single‐residue variants, are compared based on crystal structures and activity assays. A high structural similarity is demonstrated, suggesting the equivalent involvement of relevant residues in the reaction mechanism and catalytic dependence on cation–π interaction ...
F. Helfrich, Axel J. Scheidig
wiley   +1 more source

The new insight into extracellular NAD+ degradation‐the contribution of CD38 and CD73 in calcific aortic valve disease

Journal of Cellular and Molecular Medicine, Volume 25, Issue 13, Page 5884-5898, July 2021., 2021
Abstract Nicotinamide adenine dinucleotide (NAD+) is crucial for cell energy metabolism and many signalling processes. Recently, we proved the role of ecto‐enzymes in controlling adenine nucleotide–dependent pathways during calcific aortic valve disease (CAVD).
Patrycja Jablonska, Barbara Kutryb‐Zajac, Paulina Mierzejewska, Agnieszka Jasztal, Barbara Bocian, Romuald Lango, Jan Rogowski, Stefan Chlopicki, Ryszard T. Smolenski, Ewa M. Slominska   +9 more
wiley   +1 more source

It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]

, 2016
The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core   +2 more sources

Endurance exercise resistance to lipotoxic cardiomyopathy is associated with cardiac NAD+/dSIR2/PGC-1α pathway activation in old Drosophila

Biology Open, 2019
Lipotoxic cardiomyopathy is caused by excessive lipid accumulation in myocardial cells and it is a form of cardiac dysfunction. Cardiac PGC-1α overexpression prevents lipotoxic cardiomyopathy induced by a high-fat diet (HFD).
Deng-Tai Wen, Lan Zheng, Jin-xiu Li, Dan Cheng, Yang Liu, Kai Lu, Wen-qi Hou   +6 more
doaj   +1 more source