Effects of deletions in the central helix of calmodulin on enzyme activation and peptide binding. [PDF]
, 1989 Journal ArticleUsing site-directed mutagenesis we have expressed in Escherichia coli three engineered calmodulins (CaM) containing deletions in the solvent-exposed region of the central helix.
Blumenthal, Donald K. +1 more
core
Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases [PDF]
, 2014 Physical inactivity is a predisposing factor for various disease states including obesity, cardiovascular disease, as well as for certain types of cancer. Regular endurance exercise mediates several beneficial effects such as increased energy expenditure
Handschin, Christoph +1 more
core +1 more source
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis
Aging and Cancer, Volume 3, Issue 3-4, Page 133-146, September-December 2022., 2022 One‐third of DLBCL arises from extranodal organs and is challenging to manage. Molecular features are critical to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and ...
Si‐Yuan Chen +3 more
wiley +1 more source
MD and EPR studies of the structure and dynamics of the MTSL spin-labelled activation loop of the Aurora-A kinase [PDF]
arXiv, 2015 The understanding of kinase structure is mostly based on protein crystallography, which is limited by the requirement to trap molecules within a crystal lattice. Therefore, characterisations of the conformational dynamics of the activation loop in solution are important to enhance the understanding of molecular processes related to diseases and to ...
arxiv
Molecular Oncology, EarlyView.In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen +17 more
wiley +1 more source
Molecular cloning and identification ofUTR1of a yeastSaccharomyces cerevisiaeas a gene encoding an NAD kinase [PDF]
, 2001 Shigeyuki Kawai +3 more
openalex +2 more sources
5-Hydroxytryptamine1A receptor/Giβγ stimulates mitogen-activated protein kinase via NAD(P)H oxidase and reactive oxygen species upstream of Src in Chinese hamster ovary fibroblasts [PDF]
, 2000 Y. Mukhin +8 more
openalex +2 more sources
Nicotinamide Administration Improves Remyelination after Stroke
Neural Plasticity, 2017 Aims. Stroke is a leading cause of morbidity and mortality. This study aimed to determine whether nicotinamide administration could improve remyelination after stroke and reveal the underlying mechanism. Methods.
Congxiao Wang +6 more
doaj +1 more source
NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy.
PLoS Biology, 2012 Muscular dystrophies are common, currently incurable diseases. A subset of dystrophies result from genetic disruptions in complexes that attach muscle fibers to their surrounding extracellular matrix microenvironment.
Michelle F Goody +5 more
doaj +1 more source