Results 51 to 60 of about 923,736 (263)
Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53 independent pathways [PDF]
, 2014 Most cancer cells use aerobic glycolysis to fuel their growth. The enzyme lactate dehydrogenase-A (LDH-A) is key to cancer’s glycolytic phenotype, catalysing the regeneration of nicotinamide adenine dinucleotide (NAD þ ) from reduced nicotinamide adenine
Allison, Simon J. +6 more
core +1 more source
Can Aspartate Aminotransferase in the Cerebrospinal Fluid Be a Reliable Predictive Parameter?
Brain Sciences, 2020 Brain ischemia after central nervous system (CNS) bleeding significantly influences the final outcome of patients. Catalytic activities of aspartate aminotransferase (AST) in the cerebrospinal fluid (CSF) to detect brain ischemia were determined in this ...
Petr Kelbich +9 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga +8 more
wiley +1 more source
The Journal of Cell Biology, 2005 ![][1] Severed axons degenerate (top; left to right) but can be rescued by Nmat expression or NAD (bottom). NAD helps counteract energy leakage from severed axons, report Wang et al. on page 349.Recently, Araki et al. ( Science .
openaire +2 more sources
, 2011 We have measured the dependence of the hysteretic voltage-induced torsional strain (VITS) in crystals of orthorhombic tantalum trisulfide on temperature and applied torque.
F. Ya. Nad’ +3 more
core +1 more source
Whole blood NAD and NADP concentrations are not depressed in subjects with clinical pellagra [PDF]
, 2007 Population surveys for niacin deficiency are normally based on clinical signs or on biochemical measurements of urinary niacin metabolites. Status may also be determined by measurement of whole blood NAD and NADP concentrations. To compare these methods,
Cheung, E +5 more
core +2 more sources
No significant retinal damage induced by major orthopedic surgery - a pilot study
Biomedical Papers, 2022 Background. Perioperative visual loss is one of the rare but devastating complications of anesthesia and surgery. The incidence of less severe or even subclinical postoperative visual dysfunction is unknown.
Tomas Parizek +4 more
doaj +1 more source
Effects of Aging on Glucose and Lipid Metabolism in Mice
Aging Cell, Volume 24, Issue 4, April 2025.Lien et al. report a characterization of metabolism with aging across three different strains of mice. They find that glucose metabolism is robust during healthy aging; however, aging tissues exhibit evidence of upregulated fatty acid and sphingolipid metabolism reactions that regenerate NAD+ from NADH.
Evan C. Lien +8 more
wiley +1 more source
Evaluation of NAD(+)-dependent DNA ligase of mycobacteria as a potential target for antibiotics [PDF]
, 2007 Mycobacteria contain genes for several DNA ligases, including ligA, which encodes a NAD+-dependent enzyme that has been postulated to be a target for novel antibacterial compounds.
Bowater, Richard P. +6 more
core +2 more sources
Magnetic Resonance in Medicine, Volume 93, Issue 1, Page 18-30, January 2025.Abstract Purpose This goal of this study was to optimize spectrally selective 1H‐MRS methods for large‐volume acquisition of low‐concentration metabolites with downfield resonances at 7 T and 3 T, with particular attention paid to detection of nicotinamide adenine dinucleotide (NAD+) and tryptophan.
Neil E. Wilson +5 more
wiley +1 more source