Results 51 to 60 of about 1,064,600 (267)

Fragment-based discovery of a regulatory site in thioredoxin glutathione reductase acting as "doorstop" for NADPH entry [PDF]

, 2018
Members of the FAD/NAD-linked reductase family are recognized as crucial targets in drug development for cancers, inflammatory disorders, and infectious diseases.
Angelucci, Francesco, Ardini, Matteo, Arner, Elias S. J., Bellelli, Andrea, Boumis, Giovanna, Chen, Qing, Fata, Francesca, Ippoliti, Rodolfo, Jadhav, Ajit, Lea, Wendy A., Lyu, Haining, Miele, Adriana E., Petukhov, Pavel A., Silvestri, Ilaria, Simeonov, Anton, Thatcher, Gregory R. J., Williams, David L.   +16 more
core   +3 more sources

Vitamins Reverse Endothelial Dysfunction Through Regulation of eNOS and NAD(P)H Oxidase Activities [PDF]

, 2003
Antioxidant vitamins C and E have protective properties in genetic hypertension associated with enhanced oxidative stress. This study investigated whether vitamins C and/or E modulate vascular function by regulating enzymatic activities of endothelial ...
Bayraktutan, Ulvi, McKeown, Pascal, Ulker, Sible   +2 more
core   +2 more sources

State of Brownfields in the Northern Bohemia, Saxony and Lower Silesian Regions and Prospects for Regeneration by Utilization of the Phytotechnology with the Second Generation Crops

Land, 2023
The need to achieve the sustainability goals and to reduce the continuous exploitation of the limited urban areas increases requests for the regeneration of brownfields.
Robert Ato Newton, Valentina Pidlisnyuk, Eliška Wildová, Ludmila Nováková, Josef Trögl   +4 more
doaj   +1 more source

Impurity effect on low-temperature polarisation of the charge-density-waves in o-TaS$_3$

, 1998
The temperature dependence of the low-temperature dielectric response is studied in o-TaS$_3$ samples doped by Nb, Se, and Ni and for nominally pure ones.
Baklanov, Beleznay, Biljaković, Cava, Cava, Fuller, Kriza, Kriza, Larkin, McCarten, Mihaly, N.I. Baklanov, Nad', Nad', Nad', P. Monceau, S.V. Zaitsev-Zotov, V.V. Frolov, Volkov, Yang, Zaitsev-Zotov, Zettl   +21 more
core   +1 more source

A Shift in Central Metabolism Accompanies Virulence Activation in Pseudomonas aeruginosa. [PDF]

, 2020
The availability of energy has significant impact on cell physiology. However, the role of cellular metabolism in bacterial pathogenesis is not understood.
Chacko, Jenu V, Digman, Michelle A, Kannan, Anerudh, Perinbam, Kumar, Siryaporn, Albert   +4 more
core   +1 more source

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Nature Communications, 2018
Nicotinamide adenine dinucleotide (NAD+) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calorie restriction on healthspan.
C. Martens, Blair A. Denman, Melissa R Mazzo, M. Armstrong, N. Reisdorph, M. McQueen, M. Chonchol, D. Seals   +7 more
semanticscholar   +1 more source

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source

Outlook of logging perspectives in the Czech Republic for the period 2013-2032

Journal of Forest Science, 2014
The aim of the submitted work was to analyze the outlook of logging perspectives in the next two decades (2013-2032) for all forests in the territory of the Czech Republic.
M. Synek, J. Vašíček, M. Zeman
doaj   +1 more source

NAD tagSeq reveals that NAD+-capped RNAs are mostly produced from a large number of protein-coding genes in Arabidopsis. [PDF]

, 2019
The 5' end of a eukaryotic mRNA transcript generally has a 7-methylguanosine (m7G) cap that protects mRNA from degradation and mediates almost all other aspects of gene expression.
Cai, Zongwei, Chen, Xuemei, Ni, Min, Shao, Xiaojian, Xia, Yiji, Zhang, Hailei, Zhang, Shoudong, Zhong, Huan   +7 more
core  

CD38 ecto-enzyme in immune cells is induced during aging regulating NAD+ and NMN levels

Nature Metabolism, 2020
Decreased NAD+ levels have been shown to contribute to metabolic dysfunction during aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38.
Claudia C S Chini, Thais R. Peclat, G. Warner, Sonu Kashyap, J. Espindola-Netto, Guilherme C. de Oliveira, Lilian S. Gomez, K. Hogan, M. Tarragó, A. Puranik, Guillermo Agorrody, Katie L. Thompson, K. Dang, S. Clarke, Bennett G. Childs, K. Kanamori, M. A. Witte, Paola Vidal, Anna L Kirkland, M. De Cecco, K. Chellappa, Melanie R. McReynolds, Connor S. R. Jankowski, T. Tchkonia, J. Kirkland, J. Sedivy, J. V. van Deursen, D. Baker, W. van Schooten, J. Rabinowitz, J. Baur, E. Chini   +31 more
semanticscholar   +1 more source