Activity of NAD(P)H-Oxidoreductases in Ovarian Cancer [PDF]
BiomedicinesReactive oxygen species (ROS) play an important and controversial role in carcinogenesis. Microsomal redox chains containing NADH- and NADPH-dependent oxidoreductases are among the main sites of intracellular ROS synthesis, but their role in the ...
Maria V. Fedorova +3 more
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The two alternative NADH:quinone oxidoreductases from Staphylococcus aureus: two players with different molecular and cellular roles [PDF]
Microbiology SpectrumStaphylococcus aureus is an opportunistic pathogen that has emerged as a major public health threat due to the increased incidence of its drug resistance. S.
Filipa V. Sena +7 more
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Assessing POR and CYB5R1 oxidoreductase-mediated oxidative rupture of PUFA in liposomes
STAR Protocols, 2021 Summary: Lipid peroxidation of polyunsaturated fatty acid (PUFA) phospholipids induces necrotic cell death through compromised cell membrane integrity during ferroptosis.
Bo Yan +3 more
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The oxidoreductases POR and CYB5R1 catalyze lipid peroxidation to execute ferroptosis
Molecular & Cellular Oncology, 2021 Our recent study showed that two oxidoreductases – NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1) – transfer electrons to oxygen to generate hydrogen peroxide (H2O2).
Youwei Ai, Bo Yan, Xiaodong Wang
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Copper oxide-based cathode for direct NADPH regeneration
Scientific Reports, 2021 Nearly a fourth of all enzymatic activities is attributable to oxidoreductases, and the redox reactions supported by this vast catalytic repertoire sustain cellular metabolism.
J. T. Kadowaki +4 more
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Research, 2021 Solar-driven photocatalytic regeneration of cofactors, including reduced nicotinamide adenine dinucleotide (NADH), reduced nicotinamide adenine dinucleotide phosphate (NADPH), and reduced flavin adenine dinucleotide (FADH2), could ensure the sustainable ...
Yuqing Cheng +7 more
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Characterization of NADH Oxidase/NADPH Polysulfide Oxidoreductase and Its Unexpected Participation in Oxygen Sensitivity in an Anaerobic Hyperthermophilic Archaeon [PDF]
Journal of Bacteriology, 2010 ABSTRACT Many genomes of anaerobic hyperthermophiles encode multiple homologs of NAD(P)H oxidase that are thought to function in response to oxidative stress. We investigated one of the seven NAD(P)H oxidase homologs (TK1481) in the sulfur-reducing hyperthermophilic archaeon Thermococcus kodakarensis ...
Satoshi Nakamura +5 more
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Identification of oxidoreductases from the petroleum Bacillus safensis strain
Biotechnology Reports, 2015 A gram-positive bacterium, denominated CFA-06, was isolated from Brazilian petroleum in the Campos Basin and is responsible for the degradation of aromatic compounds and petroleum aromatic fractions.
Francine S.A. da Fonseca +12 more
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The reaction of NADPH with bovine mitochondrial NADH:ubiquinone oxidoreductase revisited [PDF]
Journal of Bioenergetics and Biomembranes, 2010 Bovine NADH:ubiquinone oxidoreductase (Complex I) is the first complex in the mitochondrial respiratory chain. It has long been assumed that it contained only one FMN group. However, as demonstrated in 2003, the intact enzyme contains two FMN groups. The second FMN was proposed to be located in a conserved flavodoxin fold predicted to be present in the
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Reduction of the plastoquinone pool by exogenous NADH and NADPH in higher plant chloroplasts
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1998 Chlorophyll fluorescence measurements were performed on osmotically lysed potato chloroplasts in order to characterize the reactions involved in the dark reduction of photosynthetic inter-system chain electron carriers. Addition of NADH or NADPH to lysed chloroplasts increased the chlorophyll fluorescence level measured in the presence of a non-actinic
Michel Havaux +4 more
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