Results 1 to 10 of about 61 (60)

Reactive Oxygen Species: From Tumorigenesis to Therapeutic Strategies in Cancer

Cancer Medicine, Volume 14, Issue 10, May 2025.
ABSTRACT Background Reactive oxygen species (ROS), a class of highly reactive molecules, are closely linked to the pathogenesis of various cancers. While ROS primarily originate from normal cellular processes, external stimuli can also contribute to their production. Cancer cells typically exhibit elevated ROS levels due to disrupted redox homeostasis,
Iqra Attique, Zahra Haider, Maha Khan, Samina Hassan, Mohamed Mohamed Soliman, Wisam Nabeel Ibrahim, Sumaira Anjum   +6 more
wiley   +1 more source

NADH Driven Enzymatic Carboxylic Acid Reduction

ChemCatChem, Volume 17, Issue 9, May 8, 2025.
Run your carboxylic acid reductase (CAR) with NADH? Yes, because well‐known CARs use NADH. NADPH remains the preferred cofactor for various diverse CARs but high conversions are possible also with NADH. We show a new Type of CAR that produces alcohols from the respective acids in the presence of either NADH or NADPH. Abstract Carboxylic acid reductases
Jonathan Guyang Ling, Hannah G. Breuer, Holly Stolterfoht‐Stock, Farah Diba Abu Bakar, Margit Winkler   +4 more
wiley   +1 more source

Proteomic and Metabolomic Analysis of the Neuroprotective Effects of Lycium Ruthenicum Polyphenols in Diabetic Peripheral Neuropathy Mice

Food Science &Nutrition, Volume 13, Issue 5, May 2025.
After 8 weeks of treatment, LRP showed multiple neuroprotective effects on nerve damage in the DPN model mice. The proteomics and metabolomics identified several possible mechanisms for their therapeutic effects: (1) improving mitochondrial function, especially improving the OXPHOS process; (2) increasing the abundance of cytoskeletal and structural ...
Qi Tian, Hongdou Cao, Liwen Chu, Hua Gao, Qinghan Gao   +4 more
wiley   +1 more source

Pituitary 5 alpha-dihydroprogesterone 3 alpha-hydroxysteroid oxidoreductases. Subcellular location and properties of NADH- and NADPH-linked activities.

Journal of Biological Chemistry, 1980
H J Karavolas, J E Krause
openaire   +3 more sources

Characterization of NADH Oxidase/NADPH Polysulfide Oxidoreductase and Its Unexpected Participation in Oxygen Sensitivity in an Anaerobic Hyperthermophilic Archaeon

Characterization of NADH Oxidase/NADPH Polysulfide Oxidoreductase and Its Unexpected Participation in Oxygen Sensitivity in an Anaerobic Hyperthermophilic Archaeon
identifier:oai:t2r2.star.titech.ac.jp ...
openaire  

Regulation of the NADH and NADPH-ferredoxin oxidoreductases in Clostridia of the butyric group

Biochimica et Biophysica Acta (BBA) - General Subjects, 1976
NADH and NADPH-ferredoxin oxidoreductases have been studied in Clostridium acetobutylicum, Cl. tyrobutyricum and Cl. pasteurianum. The study of the distribution and regulation of these enzymatic activities in well-defined culture conditions, reveals that the essential function of NADPH-ferredoxin oxidoreductase is to produce NADPH, while NADH ...
H, Petitdemange, C, Cherrier, R, Raval, R, Gay   +3 more
openaire   +3 more sources

NADH(NADPH):(Acceptor) oxidoreductase activities of the bovine adrenal chromaffin granules

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1973
Abstract 1. 1. An analysis of the NADH(NADPH):(acceptor) oxidoreductase activities of adrenal chromaffin granules depleted of low molecular weight substances (notably catecholamines and ATP), has been made in terms of the flavoprotein(s) and cytochrome b 561 previously reported (Flatmark, T., Terland, O. and Helle, K. B.
Torgeir Flatmark, Ole Terland
openaire   +3 more sources

Purification and properties of the NADH and NADPH specific FMN oxidoreductases from Beneckea harveyi

Biochemistry, 1977
The NADH and NADPH specific FMN oxidoreductases from Beneckea harveyi have been purified to homogeneity as judged by single bands on sodium dodecyl sulfate gel electrophoresis. The overall purification for the NADH specific enzyme is 3000-fold and 4000-fold for the NADPH specific enzyme from a crude extract. The final step in the purification procedure
Marlene DeLuca, Edward Jablonski
openaire   +3 more sources

Properties of the hypothalamic 5α-dihydroprogesterone NADH- and NADPH-linked 3α-hydroxysteroid oxidoreductase activities

Journal of Steroid Biochemistry, 1981
Abstract Rat hypothalamic 5α-dihydroprogesterone NADH-linked 3α-hydroxysteroid oxidoreductase, (3α-HSD) activity, which is associated with plasma membranes, has a relatively sharp pH optimum of 5.5 and a temperature optimum range of 45–52°C. This enzyme exhibited apparent K m 's for the reductive reaction of 0.40 ± 0.09 μm and 29 ± 12 μ M for ...
James E. Krause, Harry J. Karavolas
openaire   +3 more sources

Continuous monitoring of reactions that produce NADH and NADPH using immobilized luciferase and oxidoreductases from Beneckea harveyi

Analytical Biochemistry, 1978
Abstract Highly purified NADH and NADPH:FMN oxidoreductase and luciferase isolated from Beneckea harveyi have been immobilized to arylamine glass beads which were cemented to glass rods. The immobilized enzyme rods are stable, reuseable, and specific for either NADH or NADPH.
Colin Haggerty, Marlene DeLuca, Edward Jablonski, Laureen Stav   +3 more
openaire   +3 more sources