Results 11 to 20 of about 8,783 (160)

Redox-dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells. [PDF]

FEBS Lett
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Blacker TS, Mistry N, Plotegher N, Westbrook ER, Sewell MDE, Carroll J, Szabadkai G, Bain AJ, Duchen MR.   +8 more
europepmc   +3 more sources

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, EarlyView., 2023
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Cofactor regeneration by a soluble pyridine nucleotide transhydrogenase for biological production of hydromorphone [PDF]

, 2000
We have applied the soluble pyridine nucleotide transhydrogenase of Pseudomonas fluorescens to a cell-free system for the regeneration of the nicotinamide cofactors NAD and NADP in the biological production of the important semisynthetic opiate drug ...
Boonstra, B, Bruce, N C, French, C E, Rathbone, D A, Walker, E H   +4 more
core   +2 more sources

Ochrobactrum sp. MPV1 from a dump of roasted pyrites can be exploited as bacterial catalyst for the biogenesis of selenium and tellurium nanoparticles [PDF]

, 2017
Background: Bacteria have developed different mechanisms for the transformation of metalloid oxyanions to non-toxic chemical forms. A number of bacterial isolates so far obtained in axenic culture has shown the ability to bioreduce selenite and tellurite
Dell'Anna R., Lampis S., Monti F., Piacenza E., Presentato A., Vallini G., Zonaro E.   +6 more
core   +1 more source

Electron bifurcation mechanism and homoacetogenesis explain products yields in mixed culture anaerobic fermentations [PDF]

, 2017
Anaerobic fermentation of organic wastes using microbial mixed cultures is a promising avenue to treat residues and obtain added-value products. However, the process has some important limitations that prevented so far any industrial application.
González-Cabaleiro, R., Lema, J.M., Ofiţeru, I.D., Regueira, A., Rodríguez, J.   +4 more
core   +4 more sources

Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages [PDF]

, 2008
This study provides the proof of principle that probing the host and the microbe transcriptomes simultaneously is a valuable means to accessing unique information on host pathogen interactions.
A Kolb-Maurer, A Kumar, A Savina, A Yamauchi, A Yoshimura, Alessandra Mortellaro, AM Talaat, AM Talaat, Antoine Tanne, B Hutter, B Pron, BM Bolstad, Brigitte Gicquel, C Nathan, CH Wang, D Chaussabel, D Lombardi, D Schnappinger, D Schnappinger, D Werling, Derya Unutmaz, DG Russell, DJ Beste, DM Roberts, E Giacomini, E Werner, F Niedergang, FS Machado, G Cappelli, G Harth, G Sulzenbacher, GJ Nau, GK Smyth, GK Smyth, GR Stewart, H Ohno, H Rachman, HD Park, I Vergne, J Bacon, JA Mangan, JC Betts, JC Boldrick, JD McKinney, JP Wang, L Shi, L Tailleux, LP Barker, LR Camacho, Ludovic Tailleux, M Kanehisa, M Kanehisa, M Pelizzola, MA Harris, Maria Foti, Mattia Pelizzola, MB Eisen, MI Voskuil, Michael Withers, MM Westcott, MV Tullius, N Mohagheghpour, Neil G. Stoker, Olivier Neyrolles, P Ricciardi-Castagnoli, Paola Ricciardi Castagnoli, PC Karakousis, Philip D. Butcher, R Van der Geize, RA Henderson, RA Irizarry, S Ehrt, S Nicholson, S Ragno, S Stenger, S Sturgill-Koszycki, Simon J. Waddell, SJ Waddell, SJ Waddell, SL Kendall, SL Kendall, ST Cole, T Kawai, T Parish, X Jiao, Y Hu, Y Yuan   +86 more
core   +5 more sources

Characterization of the novel ene reductase Ppo-Er1 from paenibacillus polymyxa [PDF]

, 2020
Ene reductases enable the asymmetric hydrogenation of activated alkenes allowing the manufacture of valuable chiral products. The enzymes complement existing metal- and organocatalytic approaches for the stereoselective reduction of activated C=C double ...
Aregger, David, Buller, Rebecca, Peters, Christin   +2 more
core   +1 more source

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]

, 2011
<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I., Engel, P.C., Llinas, M., Muller, S., Olszewski, K., Patzewitz, E.-M., Perner, J., Storm, J.   +7 more
core   +4 more sources

Respiratory electron transfer pathways in plant mitochondria [PDF]

, 2014
The respiratory electron transport chain (ETC) couples electron transfer from organic substrates onto molecular oxygen with proton translocation across the inner mitochondrial membrane.
Braun, Hans-Peter, Schertl, Peter
core   +4 more sources

The genome of Pelobacter carbinolicus reveals surprising metabolic capabilities and physiological features [PDF]

, 2012
Background The bacterium Pelobacter carbinolicus is able to grow by fermentation, syntrophic hydrogen/formate transfer, or electron transfer to sulfur from short-chain alcohols, hydrogen or formate; it does not oxidize acetate and is not known to ferment
Cliff S Han, Derek R Lovley, Miriam L Land, Muktak Aklujkar, Olga Chertkov, Peter Brown, Raymond DiDonato, Shelley A Haveman   +7 more
core   +2 more sources