Results 11 to 20 of about 61 (60)
NRF2 signalling in cytoprotection and metabolism
British Journal of Pharmacology, EarlyView., 2023 The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami +4 more
wiley +1 more source
Characterization of NADH Oxidase/NADPH Polysulfide Oxidoreductase and Its Unexpected Participation in Oxygen Sensitivity in an Anaerobic Hyperthermophilic Archaeon [PDF]
Journal of Bacteriology, 2010 ABSTRACT Many genomes of anaerobic hyperthermophiles encode multiple homologs of NAD(P)H oxidase that are thought to function in response to oxidative stress. We investigated one of the seven NAD(P)H oxidase homologs (TK1481) in the sulfur-reducing hyperthermophilic archaeon Thermococcus kodakarensis ...
Satoshi Nakamura +5 more
openaire +3 more sources
The reaction of NADPH with bovine mitochondrial NADH:ubiquinone oxidoreductase revisited [PDF]
Journal of Bioenergetics and Biomembranes, 2010 Bovine NADH:ubiquinone oxidoreductase (Complex I) is the first complex in the mitochondrial respiratory chain. It has long been assumed that it contained only one FMN group. However, as demonstrated in 2003, the intact enzyme contains two FMN groups. The second FMN was proposed to be located in a conserved flavodoxin fold predicted to be present in the
openaire +10 more sources
Reduction of the plastoquinone pool by exogenous NADH and NADPH in higher plant chloroplasts
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1998 Chlorophyll fluorescence measurements were performed on osmotically lysed potato chloroplasts in order to characterize the reactions involved in the dark reduction of photosynthetic inter-system chain electron carriers. Addition of NADH or NADPH to lysed chloroplasts increased the chlorophyll fluorescence level measured in the presence of a non-actinic
Michel Havaux +4 more
openaire +3 more sources
Two Key Ferredoxins for Nitrogen Fixation Have Different Specificities and Biophysical Properties
Chemistry – A European Journal, EarlyView.Two ferredoxins, FdC and FdN, are collectively essential for the process of nitrogen fixation by the iron nitrogenase in R. capsulatus. We explore the biophysical factors, through spectroscopic and structural characterizations, which determine ferredoxin functionality and pathway specificity. The structure of FdC (PDB: 9I2A) and model of FdN (AF‐D5ARY6)
Holly Addison +5 more
wiley +1 more source
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 2004 Numerous data indicate that cellular oxidoreductases may be responsible for the cardiotoxic effects of antitumor anthracycline drugs as a consequence of the mediation by these agents of one-electron transfer from reduced nucleotides to atmospheric oxygen.
C. Roland Wolf +6 more
openaire +2 more sources
Limnology and Oceanography, EarlyView.Abstract Purple sulfur bacteria (PSB) of the family Chromatiaceae (Gammaproteobacteria) can perform chemo‐ and photo‐lithoautotrophy (through anoxygenic photosynthesis) in anoxic layers of freshwater stratified (including meromictic) lakes. This group has been extensively studied via physiological and ecological approaches, albeit their genomics has ...
Pedro J. Cabello‐Yeves +7 more
wiley +1 more source
PROTEOMICS, EarlyView.ABSTRACT Isolated complex I deficiency (ICD) is commonly associated with mitochondrial diseases and closely mimics subacute necrotising encephalomyelopathy. This disorder is characterised by metabolic perturbations that affect energy metabolism pathways, including fatty acid metabolism.
Sibonelo Glen Khumalo +2 more
wiley +1 more source
NQO1‐Responsive Prodrug for in Cellulo Release of Cytochalasin B as Cancer Cell‐Targeted Migrastatic
Small, EarlyView.The design, synthesis, biochemical, and cell biological evaluation of the NQO1‐targeted prodrug BQTML‐CB is reported. BQTML‐CB selectively releases cytochalasin B upon activation by the quinone‐oxidoreductase NQO1 associated with invasiveness of cancer cells, representing a novel approach to improve cancer selectivity and reduce immunosuppressive ...
Mervic D. Kagho +10 more
wiley +1 more source
Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?
Acta Ophthalmologica, EarlyView.Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs +12 more
wiley +1 more source