Results 21 to 30 of about 8,934 (160)

The Ability of New Sugar-Modified Derivatives of Antitumor Anthracycline, Daunorubicin, to Stimulate NAD(P)H Oxidation in Different Cellular Oxidoreductase Systems: NADH Dehydrogenase, NADPH Cytochrome P450 Reductase, and Xanthine Oxidase

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 2004
Numerous data indicate that cellular oxidoreductases may be responsible for the cardiotoxic effects of antitumor anthracycline drugs as a consequence of the mediation by these agents of one-electron transfer from reduced nucleotides to atmospheric oxygen.
Jolanta, Pawłowska, Waldemar, Priebe, Mark J I, Paine, C Roland, Wolf, Edward, Borowski, Jolanta, Tarasiuk   +5 more
openaire   +2 more sources

Unusual Metabolism and Hypervariation in the Genome of a Gracilibacterium (BD1-5) from an Oil-Degrading Community. [PDF]

, 2019
The candidate phyla radiation (CPR) comprises a large monophyletic group of bacterial lineages known almost exclusively based on genomes obtained using cultivation-independent methods.
Andersen, Gary L, Banfield, Jillian F, Castelle, Cindy J, Hu, Ping, Paul, Blair G, Sieber, Christian MK, Tringe, Susannah G, Valentine, David L   +7 more
core   +2 more sources

Identification of novel members of the bacterial azoreductase family in 'Pseudomonas aeruginosa' [PDF]

, 2016
Azoreductases are a family of diverse enzymes found in many pathogenic bacteria as well as distant homologues being present in eukarya. In addition to having azoreductase activity these enzymes are also suggested to have NAD(P)H quinone oxidoreductase ...
Crescente, Vincenzo, Holland, Sinead M., Kashyap, Sapna, Polycarpou, Elena, Ryan, Ali, Sim, Edith   +5 more
core   +1 more source

General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH [PDF]

, 2013
To date, efforts to switch the cofactor specificity of oxidoreductases from nicotinamide adenine dinucleotide phosphate (NADPH) to nicotinamide adenine dinucleotide (NADH) have been made on a case-by- case basis with varying degrees of success.
Arnold, Frances H., Brinkmann-Chen, Sabine, Brustad, Eric M., Cahn, Jackson K. B., Flock, Tilman, McIntosh, John A., Meinhold, Peter, Snow, Christopher D., Zhang, Liang   +8 more
core   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Biotransformation of explosives by the old yellow enzyme family of flavoproteins [PDF]

, 2004
Several independent studies of bacterial degradation of nitrate ester explosives have demonstrated the involvement of flavin-dependent oxidoreductases related to the old yellow enzyme (OYE) of yeast. Some of these enzymes also transform the nitroaromatic
Bruce, N.C., Rathbone, D.A., Scrutton, N.S., Williams, R.E.   +3 more
core   +2 more sources

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

Constructing and testing the thermodynamic limits of synthetic NAD(P)H:H-2 pathways [PDF]

, 2008
NAD(P)H:H(2) pathways are theoretically predicted to reach equilibrium at very low partial headspace H(2) pressure. An evaluation of the directionality of such near-equilibrium pathways in vivo, using a defined experimental system, is therefore important
Akhtar, Akhtar, Alberty, Alexeeva, Andersen, Angenent, Bautista, Blaschkowski, Brumaghim, Carrillo, Cho, Datsenko, De Vrije, Fischer, Fitzgerald, Gorwa, Gottschalk, Graves, Henry, Jungermann, Jungermann, Kimball, King, Kumar, Lamed, Lee, Lovley, Maeda, Malki, Meyer, Miller, Nakashimada, Patterson, Pauss, Pollak, Posewitz, Rabinowitz, Sambrook, Sauer, Sawers, Seo, Seo, Serres, Silva, Soboh, Steuber, Thauer, Van Groenestijn, Van Niel, Varma, Verhagen, Vignais, Walton, Woodward, Wu, Yoshida, Yoshida   +56 more
core   +1 more source

All Nanozyme‐Based Cascade Reactions for Biomedical Applications: from Self‐Cascading Nanozyme to Immobilized Cascade Nanozyme

Advanced Science, EarlyView.
This review introduces the development and classification of all‐nanozyme cascade reaction systems, highlighting mechanistic insights and research methods for understanding catalytic features and design principles. It provides detailed classifications, surveys recent applications in biosensing and therapy, and discusses the challenges that all‐nanozyme
Caixia Zhu, Congcong Jiang, Hian Kee Lee, Yuanjian Zhang, Sheng Tang   +4 more
wiley   +1 more source

Mechanism and substrate specificity of the flavin reductase ActVB from Streptomyces coelicolor. [PDF]

, 2003
International audienceActVB is the NADH:flavin oxidoreductase participating in the last step of actinorhodin synthesis in Streptomyces coelicolor. It is the prototype of a whole class of flavin reductases with both sequence and functional similarities ...
Filisetti, Laurent, Fontecave, Marc, Niviere, Vincent   +2 more
core   +3 more sources