Results 21 to 30 of about 5,417 (111)

Metabolic stimulation improves bioenergetics and haematologic indices of circulating erythrocytes from sickle cell mice

The Journal of Physiology, EarlyView.
Abstract figure legend Metabolic stimulation improves bioenergetics, redox state, hydration and hematologic indices of circulating erythrocytes from sickle cell mice. Retained mitochondria in circulating RBCs from sickle mice are a source of RBC ATP as mitochondria function (ETC, electron transport chain) inhibitors [rotenone, a mitochondrial complex I
Luis E. F. Almeida, Meghann L. Smith, Sayuri Kamimura, Sebastian Vogel, Zenaide M. N. Quezado   +4 more
wiley   +1 more source

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

The Journal of Physiology, EarlyView.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich, Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Ryan Gemilere, Samira M. Azarin, Julia C. Liu   +5 more
wiley   +1 more source

Structural and evolutionary dissection of NADPH‐binding motifs in NADPH‐preferring ene‐reductases

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Ene‐reductases (ERs) catalyze nicotinamide‐dependent, stereoselective reductions of activated CC bonds. While their catalytic chemistry and applications are well‐explored, cosubstrate (NAD(P)H) binding remains poorly understood. Most ERs strongly prefer NADPH despite lacking canonical dinucleotide‐binding folds and instead employ flexible ...
Bianca Kerschbaumer, Eva M. Frießer, Silvia Wallner, Gustav Oberdorfer, Michael Friess, Rolf Breinbauer, Peter Macheroux, Aleksandar Bijelic   +7 more
wiley   +1 more source

Enhanced Microbial Sensing via Resazurin Reduction Catalyzed by Graphene Oxide, A Versatile Approach for Diagnostics and Electrochemical Applications

Environmental Toxicology, Volume 41, Issue 4, Page 223-232, April 2026.
ABSTRACT Resazurin is a cell viability phenoxazine dye widely employed for bacterial monitoring, as its colorimetric and fluorometric conversion reflects microbial metabolic activity. In this work, we demonstrate that graphene oxide (GO), a two‐dimensional nanomaterial with high surface reactivity, markedly accelerates the reduction of resazurin in the
Valentina Palmieri, Marco de Spirito, Massimiliano Papi   +2 more
wiley   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

NQO1‐Responsive Prodrug for in Cellulo Release of Cytochalasin B as Cancer Cell‐Targeted Migrastatic

Small, Volume 22, Issue 16, 17 March 2026.
The design, synthesis, biochemical, and cell biological evaluation of the NQO1‐targeted prodrug BQTML‐CB is reported. BQTML‐CB selectively releases cytochalasin B upon activation by the quinone‐oxidoreductase NQO1 associated with invasiveness of cancer cells, representing a novel approach to improve cancer selectivity and reduce immunosuppressive ...
Mervic D. Kagho, Katharina Schmidt, Christopher Lambert, Lili Jia, Vignesh Venkatakrishnan, Luisa Mehr, Johan Bylund, Klemens Rottner, Marc Stadler, Theresia E. B. Stradal, Philipp Klahn   +10 more
wiley   +1 more source

Characterization of Phytoene Desaturase Knockout Carotenoid‐Deficient Microalgal Mutants Generated by Cas9‐Ribonucleoprotein Complexes

Physiologia Plantarum, Volume 178, Issue 2, March/April 2026.
ABSTRACT Phytoene desaturase (PDS; EC 1.3.5.5) is a key enzyme of the carotenoid biosynthetic pathway, catalyzing the desaturation of phytoene, precursor of all carotenoids. In this study, several PDS‐knockout (PDS‐KO) transformants of the chlorophyte microalga Chlamydomonas reinhardtii were generated using a reverse genetics strategy. Two single guide
Ana Molina‐Márquez, Simon Kelterborn, Peter Hegemann, Miguel Pérez‐Rodríguez, Javier Vigara, Rosa León   +5 more
wiley   +1 more source

Nitrite supplementation alleviates cerebrovascular dysfunction in chronically stressed mice, but cognitive decline remains

Experimental Physiology, Volume 111, Issue 3, Page 1483-1497, 1 March 2026.
Abstract This study aimed to determine whether sodium nitrite supplementation prevented chronic stress‐induced cerebrovascular dysfunction and cognitive decline. We hypothesize that nitrite supplementation will prevent the oxidative environment and cerebrovascular dysfunction associated with chronic stress and maintain cognitive health.
Emily Burrage, Tyler Coblentz, Saina S. Prabhu, Nicole M. Eminhizer, Ryan Childers, Randall W. Bryner, Sara E. Lewis, Brooke A. Maxwell, Evan R. DeVallance, Eric E. Kelley, Paul D. Chantler   +10 more
wiley   +1 more source

Role of Septin7 in mitochondrial dynamics and oxidative metabolism in C2C12 skeletal muscle cells

The Journal of Physiology, Volume 604, Issue 5, Page 1971-1994, 1 March 2026.
Abstract figure legend Knockdown of Septin7 alters the expression of markers responsible for mitochondrial dynamics. Members of the electron transport chain are also affected by diminished Septin7 level resulting in functional changes of mitochondrial respiration. Abstract Mitochondria are dynamic organelles that undergo fusion and fission.
Andrea Telek, Ivett Gabriella Szabó, Anikó Keller‐Pintér, Mónika Gönczi, Eliza Guti, László Szabó, Brigitta Tillmann, Zoltán Márton Kohler, László Juhász, Péter Bai, Szilárd Póliska, Zsuzsanna Gaál, László Csernoch, János Fodor   +13 more
wiley   +1 more source

Placental iron utilisation in fetal growth restriction: alterations in mitochondrial haem synthesis and iron–sulphur cluster assembly pathways

The Journal of Physiology, Volume 604, Issue 5, Page 2229-2249, 1 March 2026.
Abstract figure legend Altered iron handling and mitochondrial pathways in FGR placentas. Placental tissue from FGR pregnancies showed increased expression of iron importers, transferrin and divalent metal transporter 1, and decreased expression of the iron exporter ferroportin, suggesting that the FGR placenta is retaining iron to meet its own ...
Veronica B. Botha, Heather C. Murray, Siddharth Acharya, Kirsty G. Pringle, Roger Smith, Joshua J. Fisher   +5 more
wiley   +1 more source