Results 61 to 70 of about 158,607 (300)

A Hidden Transhydrogen Activity of a FMN-Bound Diaphorase under Anaerobic Conditions. [PDF]

PLoS ONE, 2016
BACKGROUND:Redox cofactors of NADH/NADPH participate in many cellular metabolic pathways for facilitating the electron transfer from one molecule to another in redox reactions. Transhydrogenase plays an important role in linking catabolism and anabolism,
John Collins, Ting Zhang, Scott Huston, Fangfang Sun, Y-H Percival Zhang, Jinglin Fu   +5 more
doaj   +1 more source

Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly [PDF]

, 2011
The final version of this article is available at the link below.Crucial to glucose homoeostasis in humans, the hPDC (human pyruvate dehydrogenase complex) is a massive molecular machine comprising multiple copies of three distinct enzymes (E1–E3) and an
Alan Cooper, Blass, Brautigam, Brautigam, Chamberlain, Ciszak, Cooper, David Gilbert, Donna P. McGow, Frank, Hipps, Hiromasa, Hodgson, Hoyer, Huang, Izard, J. Gordon Lindsay, Jones, Jung, Konarev, Laue, Lessard, Leung, Lynch, Mande, Margaret A. Nutley, Mayers, McCartney, Olwyn Byron, Peter Kropholler, Philip Callow, Robinson, Sanderson, Schuck, Semenyuk, Smolle, Stanley, Stoops, Svergun, Swetha Vijayakrishnan, Vijayakrishnan, Wagenknecht, Yu, Zhou, Zhou   +44 more
core   +3 more sources

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Selection of reference genes for expression analysis using quantitative real-time PCR in the pea aphid, Acyrthosiphon pisum (Harris) (Hemiptera, Aphidiae). [PDF]

PLoS ONE, 2014
To facilitate gene expression study and obtain accurate qRT-PCR analysis, normalization relative to stable expressed housekeeping genes is required. In this study, expression profiles of 11 candidate reference genes, including actin (Actin), elongation ...
Chunxiao Yang, Huipeng Pan, Yong Liu, Xuguo Zhou   +3 more
doaj   +1 more source

Inhibitor-contaminated NADH: Its Influence on Dehydrogenases and Dehydrogenase-coupled Reactions

Clinical Chemistry, 1969
Abstract Preparations of reduced NAD are known to be prone to contain a substance which inhibits the catalytic activity of LDH. (1-Lactate: NAD oxidoreductase, EC 1.1.1.27).
S G, Klotzsch, H R, Klotzsch
openaire   +2 more sources

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

COFACTOR SPECIFICITY ENGINEERING OF STREPTOCOCCUS MUTANS NADH OXIDASE 2 FOR NAD(P)+ REGENERATION IN BIOCATALYTIC OXIDATIONS

Computational and Structural Biotechnology Journal, 2014
Soluble water-forming NAD(P)H oxidases constitute a promising NAD(P)+ regeneration method as they only need oxygen as cosubstrate and produce water as sole byproduct. Moreover, the thermodynamic equilibrium of O2 reduction is a valuable driving force for
Barbara Petschacher, Nicole Staunig, Monika Müller, Martin Schürmann, Daniel Mink, Stefaan De Wildeman, Karl Gruber, Anton Glieder   +7 more
doaj   +1 more source

NADH dehydrogenases drive inward electron transfer in Shewanella oneidensis MR‐1

Microbial Biotechnology, 2023
Shewanella oneidensis MR‐1 is a promising chassis organism for microbial electrosynthesis because it has a well‐defined biochemical pathway (the Mtr pathway) that can connect extracellular electrodes to respiratory electron carriers inside the cell.
Nicholas M. Tefft, Kathryne Ford, Michaela A. TerAvest   +2 more
doaj   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Effect of respiratory inhibitors and quinone analogues on the aerobic electron transport system of Eikenella corrodens

Scientific Reports, 2021
The effects of respiratory inhibitors, quinone analogues and artificial substrates on the membrane-bound electron transport system of the fastidious β-proteobacterium Eikenella corrodens grown under O2-limited conditions were studied. NADH respiration in
Rubén D. Jaramillo-Lanchero, Paola Suarez-Alvarez, Luis Teheran-Sierra   +2 more
doaj   +1 more source