Results 11 to 20 of about 2,049 (165)

Serum proteome profiling of plateau acclimatization in men using Olink proteomics approach [PDF]

Physiological Reports
Plateau acclimatization involves adaptive changes in the body's neurohumoral regulation and metabolic processes due to hypoxic conditions at high altitudes.
Jingyu Pan, Yue Dong, Zhihao Zou, Tianyan Gu, Ling Chen, Kai Li, Li Wang, Qinghai Shi   +7 more
doaj   +3 more sources

Mitochondrial NADK, a Novel Functional Mediator of Tau Toxicity in Alzheimer's Disease [PDF]

Alzheimers Dement
Abstract Tau was first described in a 1975 PNAS paper from Marc Kirschner's lab as a brain protein that stimulates the polymerization of tubulin into microtubules (https://doi.org/10.1073/pnas.72.5.1858). Unbeknown at that time was the fact that tau is the building block of neurofibrillary tangles, and a central player in the pathogenesis of Alzheimer ...
Norambuena A.
europepmc   +4 more sources

Knockdown of NADK promotes LUAD ferroptosis via NADPH/FSP1 axis. [PDF]

J Cancer Res Clin Oncol
Abstract Background Lung cancer is a serious threat to human health and is the first leading cause of cancer death. Ferroptosis, a newly discovered form of programmed cell death associated with redox homeostasis, is of particular interest in the lung cancer, given the high oxygen environment of lung cancer.
Meng X, Peng F, Yu S, Chi X, Wang W, Shao S.   +5 more
europepmc   +5 more sources

Transcriptional Isoforms of NAD+ kinase regulate oxidative stress resistance and melanoma metastasis [PDF]

Redox Biology
Metastasizing cancer cells encounter a multitude of stresses throughout the metastatic cascade. Oxidative stress is known to be a major barrier for metastatic colonization, such that metastasizing cancer cells must rewire their metabolic pathways to ...
Graciela Cascio, Kelsey N. Aguirre, Kellsey P. Church, Riley O. Hughes, Leona A. Nease, Ines Delclaux, Hannah J. Davis, Elena Piskounova   +7 more
doaj   +2 more sources

Adipose tissue macrophage-derived miR-690 modulates adipocyte precursor cell maintenance and adipogenesis [PDF]

Molecular Metabolism
Obesity is intricately linked to various metabolic diseases; however, some individuals maintain metabolic health despite being classified as obese. A critical factor underlying this paradox is the expansion of white adipose tissue (WAT), which can occur ...
Karina Cunha e Rocha, Breanna Tan, Julia Kempf, Cristina Medina, Varsha Beldona, Chengjia Qian, Ying Duan, Qian Xiang, Ahjin Yoo, Xiaomi Du, Amit R. Majithia, Wei Ying   +11 more
doaj   +2 more sources

A feedback loop of PPP and PI3K/AKT signal pathway drives regorafenib-resistance in HCC [PDF]

Cancer & Metabolism, 2023
Background Hepatocellular carcinoma (HCC) is a principal type of liver cancer with high incidence and mortality rates. Regorafenib is a novel oral multikinase inhibitor for second-line therapy for advanced HCC.
Huihua Yang, Dahong Chen, Yafei Wu, Heming Zhou, Wenjing Diao, Gaolin Liu, Qin Li   +6 more
doaj   +2 more sources

Phenylalanine-mediated reprogramming of lipid, pentose phosphate, and energy metabolism delays senescence in Rosa roxburghii fruit [PDF]

Food Chemistry: Molecular Sciences
Although phenylalanine can inhibit fruit senescence, its effects on Rosa roxburghii remain unknown. We hypothesized that it delays senescence by modulating fatty acid metabolism, maintaining energy homeostasis, and supporting pentose phosphate pathways ...
Shuang Liu, Yiwen Zhang, Wei Chang, Yujia Zhou, Xiaochun Ding, Boyu Dong, Xuewu Duan   +6 more
doaj   +2 more sources

The role of respiration metabolism in dicyclohexylcarbodiimide and disodium succinate regulating the pulp breakdown occurrence of fresh longan (Dimocarpus longan Lour.) during storage [PDF]

Food Chemistry: X
Compared to control longan, on day 6, DCC-treated longan presented 18 %, 2 %, 15 %, 34 %, 21 %, 26 % and 10 % higher levels of pulp breakdown index, fruit respiration rate, PGI, SDH, NAD, NADH and QH2, respectively.
Yi Zheng, Yixiong Lin, Hongyi Wen, Yueying Sang, Mengshi Lin, Zhongqi Fan, Hui Wang, Yihui Chen, Yifen Lin, Hetong Lin   +9 more
doaj   +2 more sources

Differential expression of NADK in cancer of the skin: malignant melanoma.

, 2023
Skin cancer is diagnosed in nearly 1.5 million patients each year (1). While patients with basal and squamous cell carcinomas are provided with 5-year survival rates at nearly 100% and 90%, respectively, patients diagnosed with cutaneous melanoma (metastatic melanoma) are provided 5-year survival rates at 91.4% at stage I and 24.6% at stage IV (2-5 ...
Shahan Mamoor
openalex   +3 more sources

6-BA Delays the Senescence of Postharvest Cabbage Leaves by Inhibiting Respiratory Metabolism [PDF]

Foods
6-BA, a small molecule compound of cytokinins, has been proven to delay leaf senescence in different species, including Chinese flowering cabbage; however, its specific mechanism remains relatively unknown. In this study, the application of external 6-BA
Cimei Wang, Yingying Yang, Jieting Yu, Zongli Liu, Wei Wei, Jianye Chen, Jianhua Zhu, Riming Huang   +7 more
doaj   +2 more sources