Results 11 to 20 of about 2,008 (163)

Serum proteome profiling of plateau acclimatization in men using Olink proteomics approach [PDF]

Physiological Reports
Plateau acclimatization involves adaptive changes in the body's neurohumoral regulation and metabolic processes due to hypoxic conditions at high altitudes.
Jingyu Pan, Yue Dong, Zhihao Zou, Tianyan Gu, Ling Chen, Kai Li, Li Wang, Qinghai Shi   +7 more
doaj   +3 more sources

Mitochondrial NADK, a Novel Functional Mediator of Tau Toxicity in Alzheimer's Disease [PDF]

Alzheimers Dement
Abstract Tau was first described in a 1975 PNAS paper from Marc Kirschner's lab as a brain protein that stimulates the polymerization of tubulin into microtubules (https://doi.org/10.1073/pnas.72.5.1858). Unbeknown at that time was the fact that tau is the building block of neurofibrillary tangles, and a central player in the pathogenesis of Alzheimer ...
Norambuena A.
europepmc   +2 more sources

Downregulation of NAD Kinase Expression in β-Cells Contributes to the Aging-Associated Decline in Glucose-Stimulated Insulin Secretion. [PDF]

Aging Cell
Adequate NADK/NADK2 level is essential to the proper functioning of redox and folate cycles and the purine biosynthesis pathway, and as well as maintenance of GSIS response. During aging, diminished NADK/NADK2 expression alters the metabolic status quo, increasing AICAR production. The latter activates AMPK and suppresses GSIS.
Li GJ, Cheng ML, Lin YT, Ho YH, Lin G, Chiu CY, Ho HY.   +6 more
europepmc   +2 more sources

NMRK2–YAP–NADK axis preserves redox protection against myocardial ischemia/reperfusion injury [PDF]

Redox Biology
Substantial oxidative stress during myocardial ischemia/reperfusion (I/R) injury precipitates cell death and heart failure, for which translatable redox therapies remain scarce.
Chao Zhang, Jie Wang, Jing Chi, Su-ting Liu, Xiao-wen Meng, Lin-gui Li, Shunli Dong, Hui Cao, Xing-gen Zhou, Yang Zhang, Hai-yan Sun, Pei-pei Kang, Ke Peng, Fu-hai Ji   +13 more
doaj   +2 more sources

De Novo Biosynthesis of Antidepressant Psilocybin in Escherichia coli. [PDF]

Microb Biotechnol
Our work achieved de novo synthesis of antidepressant psilocybin in a single engineered Escherichia coli cell. By constructing the P450 PsiH variants with N‐terminal hydrophobic domain modifications, improving the supply of precursor tryptophan and cofactor NADPH, enhancing the electron transfer (ET) pathway and the final methylation step, and ...
Huang Z, Yao Y, Di R, Zhang J, Pan Y, Liu G.   +5 more
europepmc   +2 more sources

NFATc1-mediated activation of the pentose phosphate pathway and cell cycle dysregulation collectively drive tumor progression [PDF]

Oncogenesis
The pentose phosphate pathway (PPP) supplies abundant reducing equivalents and biosynthetic precursors to support the rapid proliferation of tumor cells. An increased PPP flux is a hallmark of metabolic reprogramming in tumors. Although nuclear factor of
Suyang Zhang, Guangyao Xu, Tianyu Cao, Fei Yu, Moses Okotel, Mingyue Wu, Shourong Wu, Vivi Kasim, Can Huang   +8 more
doaj   +2 more sources

Knockdown of NADK promotes LUAD ferroptosis via NADPH/FSP1 axis [PDF]

Journal of Cancer Research and Clinical Oncology
Abstract Background Lung cancer is a serious threat to human health and is the first leading cause of cancer death. Ferroptosis, a newly discovered form of programmed cell death associated with redox homeostasis, is of particular interest in the lung cancer, given the high oxygen environment of lung cancer.
Meng, Xiangpeng, Peng, Fang, Yu, Shijie, Chi, Xinming, Wang, Wenchi, Shao, Shujuan   +5 more
openaire   +3 more sources

Adipose tissue macrophage-derived miR-690 modulates adipocyte precursor cell maintenance and adipogenesis [PDF]

Molecular Metabolism
Obesity is intricately linked to various metabolic diseases; however, some individuals maintain metabolic health despite being classified as obese. A critical factor underlying this paradox is the expansion of white adipose tissue (WAT), which can occur ...
Karina Cunha e Rocha, Breanna Tan, Julia Kempf, Cristina Medina, Varsha Beldona, Chengjia Qian, Ying Duan, Qian Xiang, Ahjin Yoo, Xiaomi Du, Amit R. Majithia, Wei Ying   +11 more
doaj   +2 more sources

Transcriptional Isoforms of NAD+ kinase regulate oxidative stress resistance and melanoma metastasis [PDF]

Redox Biology
Metastasizing cancer cells encounter a multitude of stresses throughout the metastatic cascade. Oxidative stress is known to be a major barrier for metastatic colonization, such that metastasizing cancer cells must rewire their metabolic pathways to ...
Graciela Cascio, Kelsey N. Aguirre, Kellsey P. Church, Riley O. Hughes, Leona A. Nease, Ines Delclaux, Hannah J. Davis, Elena Piskounova   +7 more
doaj   +2 more sources

NADPH-Related Enzymes and Cancer: Facts and Insights Into the Application of Immunohistochemistry. [PDF]

Biochem Res Int
During tumorigenesis and metastasis, cancer cells initiate antioxidant defense mechanisms to prevent irreversible damage, thereby sustaining tumor growth. The functionality of reactive oxygen species (ROS)–scavenging proteins is dependent on nicotinamide adenine dinucleotide phosphate (NADPH), which is regulated by specific metabolic enzymes, which are
Scudeler CM, da Silva KS, Silva RVN, Micheletti AMR, Ribeiro KB, Machado JR, Lira RCP.   +6 more
europepmc   +2 more sources