Results 21 to 30 of about 2,049 (165)

NMN partially rescues cuproptosis by upregulating sirt2 to increase intracellular NADPH [PDF]

Scientific Reports
Cuproptosis is characterized by lipoylated protein aggregation and loss of iron–sulfur (Fe–S) proteins, which are crucial for a wide range of important cellular functions, including DNA replication and damage repair. Sirt2 and sirt4 are lipoamidases that
Yingying Zhang, Shuting Qiu, Shihan Shao, Yuejia Cao, Yu Hong, Xianrong Xu, Xuexian Fang, Chunhong Di, Jun Yang, Xiaohua Tan   +9 more
doaj   +2 more sources

Optimized network inference for immune diseased single cells [PDF]

Frontiers in Immunology
IntroductionMathematical models are powerful tools that can be used to advance our understanding of complex diseases. Autoimmune disorders such as systemic lupus erythematosus (SLE) are highly heterogeneous and require high-resolution mechanistic ...
Elena Merino Tejero, Dwain Jude Vaz, Guillermo Barturen, Guillermo Barturen, Guillermo Barturen, María Rivas-Torrubia, Marta E. Alarcón-Riquelme, Marta E. Alarcón-Riquelme, Walter Kolch, Walter Kolch, David Matallanas   +10 more
doaj   +2 more sources

NAD+ Metabolism-Related Gene Profile Can Be a Relevant Source of Squamous Cell Carcinoma Biomarkers. [PDF]

Cancers (Basel)
: Poor survival rates of squamous cell carcinomas (SCCs) are associated with high recurrence, metastasis, and late diagnosis, due in part to a limited number of reliable biomarkers.
Minafò YA, Antonini D, Dellambra E.
europepmc   +3 more sources

Unveiling blood pressure‐associated genes in aortic cells through integrative analysis of GWAS and RNA modification‐associated variants

Chronic Diseases and Translational Medicine
Background Genome‐wide association studies (GWAS) have identified more than a thousand loci for blood pressure (BP). Functional genes in these loci are cell‐type specific.
Huan Zhang, Yuxi Chen, Peng Xu, Dan Liu, Naqiong Wu, Laiyuan Wang, Xingbo Mo   +6 more
doaj   +2 more sources

NADK upregulation is an essential metabolic adaptation that enables breast cancer metastatic colonization [PDF]

, 2022
AbstractMetabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism to adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance.
Didem Ilter, Tanya Schild, Nathan P. Ward, Stanislav Drápela, Emma Adhikari, Vivien Low, Eric Le-Lau, Gina M. DeNicola, Melanie R. McReynolds, Ana P. Gomes   +9 more
openalex   +2 more sources

A Pyroptosis-Related Gene Signature Predicts Prognosis and Tumor Immune Microenvironment in Colorectal Cancer [PDF]

Technology in Cancer Research & Treatment
Pyroptosis is a programmed cell death, which garners increasing attention by relating to immune and therapy response. However, the role of pyroptosis in colorectal cancer (CRC) remains unclear.
Linjing Li PhD, Yuyi Li MD, Junyi Lin PhD, Wenjing Pang PhD   +3 more
doaj   +2 more sources

Investigation of the Relationship Between NADK and RSL3 and Exploration of Potential Usage of RSL3: Potential Applications of RSL3: Insights from Its Relationship with NADK [PDF]

Theoretical and Natural Science
Lung cancer remains the leading cause of cancer-related deaths, and ferroptosis has emerged as a potential therapeutic target due to its role in tumor suppression. RSL3, a GPX4 inhibitor, and NADK knockdown both promote ferroptosis, but their relationship in lung cancer treatment remains unexplored.
Y. Li
openalex   +2 more sources

S857 THE NUCLEOTIDE KINASE NADK CONSTITUTES A METABOLIC VULNERABILITY OF NOTCH1‐DRIVEN T‐ALL

HemaSphere, 2019
Background:Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer with a cumulative risk of ∼1 in 2,000 children by the age of 15 years and an increasing incidence over the last 30 years.Activating mutations in the NOTCH1gene are found in more than 60% of cases of T‐cell Acute Lymphoblastic leukaemia (T‐ALL) and are being targeted ...
Étienne De Braekeleer, Meidi Gu, C. Hervieux, J. Ino Hsu, Demetrios Aspris, Emilie Abby, Baskar Venkidasamy, Herwig Ponstingl, Konstantinos Tzelepis, Stefano Indraccolo, Irmela Jeremias, David Fernández‐Antorán, Margaret A. Goodell, Penelope Jones, George S. Vassiliou   +14 more
openalex   +2 more sources

Downregulation of NAD Kinase Expression in β-Cells Contributes to the Aging-Associated Decline in Glucose-Stimulated Insulin Secretion. [PDF]

Aging Cell
Adequate NADK/NADK2 level is essential to the proper functioning of redox and folate cycles and the purine biosynthesis pathway, and as well as maintenance of GSIS response. During aging, diminished NADK/NADK2 expression alters the metabolic status quo, increasing AICAR production. The latter activates AMPK and suppresses GSIS.
Li GJ, Cheng ML, Lin YT, Ho YH, Lin G, Chiu CY, Ho HY.   +6 more
europepmc   +2 more sources

De Novo Biosynthesis of Antidepressant Psilocybin in Escherichia coli. [PDF]

Microb Biotechnol
Our work achieved de novo synthesis of antidepressant psilocybin in a single engineered Escherichia coli cell. By constructing the P450 PsiH variants with N‐terminal hydrophobic domain modifications, improving the supply of precursor tryptophan and cofactor NADPH, enhancing the electron transfer (ET) pathway and the final methylation step, and ...
Huang Z, Yao Y, Di R, Zhang J, Pan Y, Liu G.   +5 more
europepmc   +2 more sources