A feedback loop of PPP and PI3K/AKT signal pathway drives regorafenib-resistance in HCC [PDF]
Cancer & Metabolism, 2023 Background Hepatocellular carcinoma (HCC) is a principal type of liver cancer with high incidence and mortality rates. Regorafenib is a novel oral multikinase inhibitor for second-line therapy for advanced HCC.
Huihua Yang +6 more
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Phenylalanine-mediated reprogramming of lipid, pentose phosphate, and energy metabolism delays senescence in Rosa roxburghii fruit [PDF]
Food Chemistry: Molecular SciencesAlthough phenylalanine can inhibit fruit senescence, its effects on Rosa roxburghii remain unknown. We hypothesized that it delays senescence by modulating fatty acid metabolism, maintaining energy homeostasis, and supporting pentose phosphate pathways ...
Shuang Liu +6 more
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The role of respiration metabolism in dicyclohexylcarbodiimide and disodium succinate regulating the pulp breakdown occurrence of fresh longan (Dimocarpus longan Lour.) during storage [PDF]
Food Chemistry: XCompared to control longan, on day 6, DCC-treated longan presented 18 %, 2 %, 15 %, 34 %, 21 %, 26 % and 10 % higher levels of pulp breakdown index, fruit respiration rate, PGI, SDH, NAD, NADH and QH2, respectively.
Yi Zheng +9 more
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Inducing disulfidptosis in tumors:potential pathways and significance. [PDF]
MedComm (2020)Exploring the mechanisms of disulfidptosis reveals potential pathways to induce tumor cell death. Tumor cells with high SLC7A11 expression uptake a large amount of cystine to meet their metabolic needs. The reduction of cystine requires the involvement of the Trx system and NADPH.
Mi T, Kong X, Chen M, Guo P, He D.
europepmc +2 more sources
6-BA Delays the Senescence of Postharvest Cabbage Leaves by Inhibiting Respiratory Metabolism [PDF]
Foods6-BA, a small molecule compound of cytokinins, has been proven to delay leaf senescence in different species, including Chinese flowering cabbage; however, its specific mechanism remains relatively unknown. In this study, the application of external 6-BA
Cimei Wang +7 more
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Chronic Diseases and Translational MedicineBackground Genome‐wide association studies (GWAS) have identified more than a thousand loci for blood pressure (BP). Functional genes in these loci are cell‐type specific.
Huan Zhang +6 more
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NMN partially rescues cuproptosis by upregulating sirt2 to increase intracellular NADPH [PDF]
Scientific ReportsCuproptosis is characterized by lipoylated protein aggregation and loss of iron–sulfur (Fe–S) proteins, which are crucial for a wide range of important cellular functions, including DNA replication and damage repair. Sirt2 and sirt4 are lipoamidases that
Yingying Zhang +9 more
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Optimized network inference for immune diseased single cells [PDF]
Frontiers in ImmunologyIntroductionMathematical models are powerful tools that can be used to advance our understanding of complex diseases. Autoimmune disorders such as systemic lupus erythematosus (SLE) are highly heterogeneous and require high-resolution mechanistic ...
Elena Merino Tejero +10 more
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NAD+ Metabolism-Related Gene Profile Can Be a Relevant Source of Squamous Cell Carcinoma Biomarkers [PDF]
Cancers (Basel): Poor survival rates of squamous cell carcinomas (SCCs) are associated with high recurrence, metastasis, and late diagnosis, due in part to a limited number of reliable biomarkers.
Antonini, Dario +2 more
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A Pyroptosis-Related Gene Signature Predicts Prognosis and Tumor Immune Microenvironment in Colorectal Cancer [PDF]
Technology in Cancer Research & TreatmentPyroptosis is a programmed cell death, which garners increasing attention by relating to immune and therapy response. However, the role of pyroptosis in colorectal cancer (CRC) remains unclear.
Linjing Li PhD +3 more
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