Results 31 to 40 of about 239,596 (347)

The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target

Journal of Hepatocellular Carcinoma, 2021
Xiangqian Guan, Yuyan Lu, Heping Zhu, Shuqi Yu, Wenxiu Zhao, Xiaoqin Chi, Chengrong Xie, Zhenyu Yin Department of Hepatobiliary Surgery, Zhongshan Hospital, Xiamen University, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular ...
Guan X, Lu Y, Zhu H, Yu S, Zhao W, Chi X, Xie C, Yin Z   +7 more
doaj  

Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis

Redox Biology, 2020
NADPH is a pivotal cofactor that maintains redox homeostasis and lipogenesis in cancer cells and interference with NADPH production is a promising approach for treating cancer.
Chang Shao, Wenjie Lu, Ye Du, Wenchao Yan, Qiuyu Bao, Yang Tian, Guangji Wang, Hui Ye, Haiping Hao   +8 more
doaj   +1 more source

The folate cycle is a new metabolic weakness of cancer

Molecular & Cellular Oncology, 2017
Cancer cells harness nutrients to support its rapid proliferation through metabolic reprogramming. Our report identified folate cycle as a metabolic target in hepatocellular carcinoma.
Derek Lee, Carmen Chak-Lui Wong
doaj   +1 more source

STAMP2 Attenuates Cardiac Dysfunction and Insulin Resistance in Diabetic Cardiomyopathy via NMRAL1-Mediated NF-κB Inhibition in Type 2 Diabetic Rats

Diabetes, Metabolic Syndrome and Obesity, 2022
Zhan Gao,1,2 Yun Ti,1 Bin Lu,1 Fang-qiang Song,1,3 Lei Zhang,1 Bo-ang Hu,1 Jia-ying Xie,1 Wei Zhang,1 Lu Han,1,4 Ming Zhong1 1The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health ...
Gao Z, Ti Y, Lu B, Song F, Zhang L, Hu B, Xie J, Zhang W, Han L, Zhong M   +9 more
doaj  

The Ca2+-Regulation of the Mitochondrial External NADPH Dehydrogenase in Plants Is Controlled by Cytosolic pH. [PDF]

PLoS ONE, 2015
NADPH is a key reductant carrier that maintains internal redox and antioxidant status, and that links biosynthetic, catabolic and signalling pathways.
Meng-Shu Hao, Anna M Jensen, Ann-Sofie Boquist, Yun-Jun Liu, Allan G Rasmusson   +4 more
doaj   +1 more source

The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders

International Journal of Molecular Sciences, 2018
For a number of years, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) was synonymous with NOX2/gp91phox and was considered to be a peculiarity of professional phagocytic cells.
Anuradha Tarafdar, G. Pula
semanticscholar   +1 more source

Application of different methods used to transfect small molecule NADPH into cells [PDF]

Jichu yixue yu linchuang
Objective To compare the three different methods for direct transfection of small exogenous nicotinamide adenine dinucleotide phosphate(NADPH) into cells by a non-metabolic pathway.
LI Haoyue, DU Wenjing, LI Wei
doaj   +1 more source

A comparative transcriptomic, fluxomic and metabolomic analysis of the response of Saccharomyces cerevisiae to increases in NADPH oxidation

BMC Genomics, 2012
Background Redox homeostasis is essential to sustain metabolism and growth. We recently reported that yeast cells meet a gradual increase in imposed NADPH demand by progressively increasing flux through the pentose phosphate (PP) and acetate pathways and
Celton Magalie, Sanchez Isabelle, Goelzer Anne, Fromion Vincent, Camarasa Carole, Dequin Sylvie   +5 more
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Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging

Nutrients, 2019
The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects against redox stress by providing reducing equivalents to antioxidants such as glutathione and thioredoxin.
P. Bradshaw
semanticscholar   +1 more source

The Glucose-Glutamine Metabolic Interplay in MCF-7 Cells, a Hormone-Sensitive Breast Cancer Model

Frontiers in Bioscience-Landmark
Background: Selective deprivation of glutamine has been shown to accelerate the generation of reactive oxygen species (ROS) and to impair the activity of a specific pentose phosphate pathway (PPP) located within the endoplasmic reticulum (ER).
Sonia Carta, Maddalena Ghelardoni, Francesca Vitale, Silvia Ravera, Vanessa Cossu, Nadia Bertola, Serena Losacco, Jonathan Martinelli, Edoardo Dighero, Mattia Riondato, Anna Maria Orengo, Matteo Bauckneht, Sabrina Chiesa, Gianmario Sambuceti, Cecilia Marini   +14 more
doaj   +1 more source