Results 41 to 50 of about 182,746 (311)
NADPH oxidase limits innate immune responses in the lungs in mice. [PDF]
PLoS ONE, 2010 Chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase in which phagocytes are defective in generating superoxide anion and downstream reactive oxidant intermediates (ROIs), is characterized by recurrent bacterial and fungal ...
Brahm H Segal +20 more
doaj +1 more source
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source
Myeloid-derived suppressor cells modulate immune responses independently of NADPH oxidase in the ovarian tumor microenvironment in mice. [PDF]
PLoS ONE, 2013 The phagocyte NADPH oxidase generates superoxide anion and downstream reactive oxidant intermediates in response to infectious threat, and is a critical mediator of antimicrobial host defense and inflammatory responses.
Heidi E Godoy +10 more
doaj +1 more source
Advanced Science, EarlyView.Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge +21 more
wiley +1 more source
PLoS ONE, 2015 Reactive oxygen species (ROS) promote the germination of several seeds, and antioxidants suppress it. However, questions remain regarding the role and production mechanism of ROS in seed germination. Here, we focused on NADPH oxidases, which produce ROS.
Yushi Ishibashi +8 more
doaj +1 more source
Advanced Science, EarlyView.This study develops gallium‐doped V2C MXene nanozymes (Ga‐V2C) to treat acetaminophen‐induced liver injury through multi‐death pathway blockade and hepatocyte regeneration. Unlike conventional single‐target therapies like N‐acetylcysteine, Ga‐V2C nanozymes enable oxidative stress suppression, apoptosis, and ferroptosis inhibition, and enhanced ...
Xiaopeng Cai +13 more
wiley +1 more source
Revista Alergia México, 2018 Background: Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by susceptibility to early-onset life-threatening bacterial and fungal infections as well as dysregulated chronic inflammation.
Carlos Andrés Arango-Franco +15 more
doaj
Unveiling Global Diversity of Patescibacteriota and Functional Interactions with Host Microbes
Advanced Science, EarlyView.Patescibacteriota represents a diverse group of ultra‐small epibiotic bacteria, which is largely overlooked. By integrating ribosomal protein S3‐based community profiling with MAG‐based metabolic potential analyses, this study provides new insights into their distribution, diversity, and potential interactions with other bacteria across diverse ...
Yanhan Ji +12 more
wiley +1 more source
ASN Neuro, 2016 The pentose phosphate pathway is the main source of NADPH, which by reducing oxidized glutathione, contributes to antioxidant defenses. Although oxidative stress plays a major role in white matter injury, significance of NADPH for oligodendrocyte ...
Ewa Kilanczyk +3 more
doaj +1 more source
Nadph Alters Duox1 Calcium Responsiveness
Redox Biology, 2023 Hydrogen peroxide is a key element in redox signaling and in setting cellular redox tone. DUOX1 and DUOX2, that directly synthesize hydrogen peroxide, are the most abundant NADPH oxidase transcripts in most epithelia. DUOX1 and DUOX2 hydrogen peroxide synthesis is regulated by intracellular calcium transients and thus cells can respond to signals and ...
openaire +3 more sources