Results 61 to 70 of about 101,541 (346)
JAMA Network Open, 2020 Key Points Question Is there a benefit associated with take-home naloxone for overdose reversals supplied to patients who are receiving treatment for opioid use disorder?
Joanna G. Katzman +7 more
semanticscholar +1 more source
Towards Better Opioid Antagonists Using Deep Reinforcement Learning [PDF]
arXiv, 2020 Naloxone, an opioid antagonist, has been widely used to save lives from opioid overdose, a leading cause for death in the opioid epidemic. However, naloxone has short brain retention ability, which limits its therapeutic efficacy. Developing better opioid antagonists is critical in combating the opioid epidemic.Instead of exhaustively searching in a ...
arxiv
Public Perceptions of Community Pharmacy-Based Naloxone Services: A National Cross-Sectional Survey
Pharmacy, 2022 Little is known about the general public’s perceptions regarding community pharmacist-delivered naloxone services at the national level. Accordingly, the purpose of this study was to describe the US general public’s awareness, knowledge, beliefs, comfort,
Lindsey A. Hohmann +3 more
doaj +1 more source
Naloxone Administration Route in Opioid Overdose: A Review of Vermont EMS Data [PDF]
, 2017 Objective: Emergency Medical System (EMS) personnel administer the direct opioid antagonist naloxone in cases of opioid overdose via intramuscular (IM), intravenous (IV), subcutaneous (SQ), intraosseous (IO), or intranasal (IN) routes. Some early studies
LaMonda, Chris, MPH +4 more
core +1 more source
Analgesic effectiveness and tolerability of oral oxycodone/naloxone and pregabalin in patients with lung cancer and neuropathic pain. An observational analysis [PDF]
, 2016 INTRODUCTION: Cancer-related pain has a severe negative impact on quality of life. Combination analgesic therapy with oxycodone and pregabalin is effective for treating neuropathic cancer pain.
Borghesi, Cristina +6 more
core +2 more sources
Naloxone dosing in the era of ultra-potent opioid overdoses: a systematic review.
CJEM, 2020 OBJECTIVES Evaluate the relationship between naloxone dose (initial and cumulative) and opioid toxicity reversal and adverse events in undifferentiated and presumed fentanyl/ultra-potent opioid overdoses.
J. Moe +10 more
semanticscholar +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano +8 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.The new ionization technique, vacuum‐insulated probe‐heated electrospray, allows for a simple dilute‐and‐shoot sample preparation to be used with liquid chromatography time‐of‐flight mass spectrometry in urine drug screening. Comparison with a method relying on solid‐phase extraction and conventional electrospray ionization shows improved performance ...
Mira Sundström +4 more
wiley +1 more source
Use of nebulized naloxone to reverse methadone overdose – A case report and review of literature
Journal of Community Hospital Internal Medicine Perspectives, 2019 Opioid use is a frequent cause of morbidity and mortality in the USA. We report a case of methadone overdose reversed with naloxone nebulization. Peripheral IV access can be difficult to obtain in patients with a history of IV drug abuse making needless ...
Muhammad Sameed, Heidi Teague
doaj +1 more source
Incorporating Naloxone Education Into Routine Primary Care [PDF]
, 2018 Opioid overdoses are a growing public health concern in Vermont and nationwide. Naloxone can save the life of someone who overdoses, if those around them know how to use it.
Goldberg, Eli
core +1 more source