Results 61 to 70 of about 78,245 (294)

Sentience in cephalopod molluscs: an updated assessment

Biological Reviews, EarlyView.
ABSTRACT This article evaluates the evidence for sentience – the capacity to have feelings – in cephalopod molluscs: octopus, cuttlefish, squid, and nautilus. Our framework includes eight criteria, covering both whether the animal's nervous system could support sentience and whether their behaviour indicates sentience.
Alexandra K. Schnell, Heather Browning, Andrew Crump, Charlotte C. Burn, Jonathan Birch   +4 more
wiley   +1 more source

Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain [PDF]

, 2006
Cannabinoid-based medicines have therapeutic potential for the treatment of pain. Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states.
Barrett, David, Chapman, Victoria, Jhaveri, Maulik, Kendall, David, Richardson, Denise   +4 more
core   +2 more sources

Use of nebulized naloxone to reverse methadone overdose – A case report and review of literature

Journal of Community Hospital Internal Medicine Perspectives, 2019
Opioid use is a frequent cause of morbidity and mortality in the USA. We report a case of methadone overdose reversed with naloxone nebulization. Peripheral IV access can be difficult to obtain in patients with a history of IV drug abuse making needless ...
Muhammad Sameed, Heidi Teague
doaj   +1 more source

Modeling Supports Combinatorial Effects Between Pharmacological and Non‐Pharmacological Interventions to Prevent Opioid‐Induced Cardiac Arrest

Clinical Pharmacology &Therapeutics, EarlyView.
Few studies have quantified the effects of non‐pharmacological interventions (e.g., rescue breathing) in the setting of community opioid overdose. We extended a previously validated model for opioid antagonists by incorporating the mechanism of rescue breathing, and quantified combinatorial effects between rescue breathing and various formulations of ...
Bradlee Thrasher, John Mann, Anik Chaturbedi, Shilpa Chakravartula, Hamed Meshkin, Affan Affan, Alexander Galluppi, Ji Young Kim, Nigar Karimli, Yue Han, Zachary Dezman, Jeffry Florian, Zhihua Li   +12 more
wiley   +1 more source

Overdose Prevention and Response A guide for people who use drugs and harm reduction staff in Eastern Europe and Central Asia [PDF]

, 2009
Provides an overview of the drug overdose problem in Eastern Europe and Central Asia; describes overdose symptoms, factors that affect overdose risk, prevention methods, and step-by-step responses to an overdose.
Curtis, Matt, Guterman, Lydia
core  

Harm reduction among injecting drug users - evidence of effectiveness [PDF]

, 2010
This chapter synthesises and evaluates the available direct evidence relating to the impact of needle and syringe programmes (NSPs), opioid substitution treatment (OST), drug consumption rooms (DCRs), and peer naloxone distribution (PND) on HIV/hepatitis
Goldberg, David, Hickman, Matthew, Hutchinson, Sharon, Kimber, Jo, Palmateer, Norah, Rhodes, Tim   +5 more
core   +1 more source

Intention to get naloxone among patients prescribed opioids for chronic pain

Harm Reduction Journal, 2022
Background Prescription opioids have been increasingly prescribed for chronic pain while the opioid-related death rates grow. Naloxone, an opioid antagonist, is increasingly recommended in these patients, yet there is limited research that investigates ...
Yinan Huang, Ning Lyu, Shrey Gohil, Shweta Bapat, E. James Essien, J. Douglas Thornton   +5 more
doaj   +1 more source

Selenium‐Containing Tea‐Derived Peptides Activate Alcohol Dehydrogenase and Ameliorate Alcohol‐Induced Liver Injury by Modulating Oxidative Stress Homeostasis

Food Frontiers, EarlyView.
The graphical abstract summarizes the experimental workflow: (1) Preparation of selenium‐containing tea‐derived peptides (TSE‐PP) guided by ADH activation; (2) Purification and LC‐MS/MS identification of selenium‐modified peptides; (3) Molecular docking to reveal peptide‐ADH interactions; (4) Evaluation of hangover‐alleviating and hepatoprotective ...
Lixia Zan, Wenyi Zhang, Ning Gao, Jing Fu, Wengang Jin, Xiaoning Zhao, Xinsheng Li, Tianli Yue   +7 more
wiley   +1 more source

Incorporating Naloxone Education Into Routine Primary Care [PDF]

, 2018
Opioid overdoses are a growing public health concern in Vermont and nationwide. Naloxone can save the life of someone who overdoses, if those around them know how to use it.
Goldberg, Eli
core   +1 more source

Factors associated with gaps in naloxone knowledge: evidence from a 2022 great plains survey

Harm Reduction Journal
Background The rising prevalence of fast-acting opioids in the USA suggests the increased need for non-professional first responder administration of naloxone.
Spencer Cooper-Ohm, Patrick Habecker, Ryan Humeniuk, Rick A. Bevins   +3 more
doaj   +1 more source