Results 61 to 70 of about 18,139 (185)

Hailey-Hailey disease successfully treated with naloxone: 2 case reports and Review of the literature on efficacy of opioid receptor antagonist in Hailey-Hailey disease patients

Journal of Dermatological Treatment
Background Hailey–Hailey disease (HHD), a genetic blistering disease, is caused by a mutation in a calcium transporter protein in the Golgi apparatus encoded by the ATP2C1 gene.
Junyou Zheng, Zhimin Duan, Beilei Xu, Hao Song, Jianbing Wu, Fang Fang, Nan Sheng, Chengrang Li   +7 more
doaj   +1 more source

The real‐world relationship between naltrexone/bupropion treatment and weight loss in Canada: A retrospective chart review

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary This study examined the change in weight at 6 months of naltrexone/bupropion (NB), a combination pharmacological therapy for weight management, in real‐world practice in Canada. The study was conducted through an observational, retrospective, single‐arm chart review of adult patients who attended the Wharton Medical Clinic in Ontario, Canada ...
Sean Wharton, Elham Kamran, Lehana Thabane, Peter Yin, Rebecca Christensen   +4 more
wiley   +1 more source

Sodium‐glucose co‐transporter 2 inhibitors and obesity‐associated cancers in people with type 2 diabetes: A real‐world observational study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To investigate the association between sodium‐glucose co‐transporter 2 inhibitors (SGLT‐2i) and obesity‐associated cancers (OAC) in individuals with type 2 diabetes (T2D). Materials and Methods This retrospective cohort study used data from the TriNetX US Collaborative Network.
Testimony Ipaye, Jonathan Goldney, Thomas Yates, Francesco Zaccardi, Kamlesh Khunti, Elina Akalestou, Melanie J. Davies, Karen Brown, Dimitris Papamargaritis   +8 more
wiley   +1 more source

Naltrexone extended-release injection: an option for the management of opioid abuse

Substance Abuse and Rehabilitation, 2011
Robert Taylor Jr1, Robert B Raffa2, Joseph V Pergolizzi Jr3,41NEMA Research Inc, Naples, FL, 2Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, 3Department of Medicine, Johns Hopkins University School of ...
Taylor Jr R, Raffa RB, Pergolizzi Jr JV
doaj  

Dyskinesias occur in response to saline and naltrexone alone after priming with combination of dopaminergic agents and naltrexone in the MPTP parkinsonian monkeys

Neurobiology of Disease, 2005
Storage of motor memory involves the basal ganglia and more precisely the striatum, which receives afferents from all regions of the cerebral cortex.
Pershia Samadi, Laurent Grégoire, Claude Rouillard, Paul J. Bédard   +3 more
doaj   +1 more source

Uptake and early outcomes of a meal replacement intervention in an ethnically diverse adult population living with obesity and significant comorbidity

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Structured meal replacement low energy diets (MR‐LED) are effective in obesity management, but evidence for individuals of minority ethnic groups or those with BMI >35 kg/m2 and significant comorbidities is limited. Materials and methods We evaluated the early effectiveness of a weight management program delivered by a multidisciplinary ...
James Shand, Naomi Brosnahan, Yannan Jiang, Rinki Murphy   +3 more
wiley   +1 more source

Predicting individual treatment response in alcohol use disorders: a reverse translational proof-of-concept study

Translational Psychiatry
The development of medications for alcohol use disorders (AUD) faces stagnation, as promising drugs failed to translate in clinic. Screening on homogeneous groups of animals drugs later tested on heterogeneous clinical cohorts may contribute to the ...
Sara De Carlo, Hela Mrizak, Andrea Della Valle, Veronica Lunerti, Manthoula O. Kyratzi, Alessandra Mammone, Antonio Lacorte, Adana Keshishian, Min Li, Esi Domi, Di Qin, Leah Solberg Woods, Laura Soverchia, Massimo Ubaldi, Roberto Ciccocioppo, Nazzareno Cannella   +15 more
doaj   +1 more source

Does Prolonged Naltrexone Therapy Alter the Rewarding Nature of Exercise, Socialization, and Eating? A Narrative Review

McGill Journal of Medicine
Introduction: Naltrexone is an opioid receptor antagonist prescribed for alcohol use disorder and opioid use disorder.  Naltrexone has a high affinity for the mu-opioid receptors, which are the primary binding site of beta-endorphin.
Caitlin Collier, Thomas Hilton
doaj   +1 more source

Weight Loss as a Determinant of Histological Improvement in Metabolic Dysfunction‐Associated Steatotic Liver Disease in People With Obesity. A Systematic Review and Network Meta‐Analysis of Randomised Clinical Trials

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) is closely linked to obesity and insulin resistance, and sustained weight loss is associated with histological improvement. Whether different obesity‐management modalities exert weight‐independent hepatic effects remains uncertain.
Matteo Monami, Amanda Belluzzi, Silvio Buscemi, Luca Busetto, Ricardo Cohen, Maurizio De Luca, Andrea Galli, Edoardo Mannucci, Tarissa Z. Petry, Benedetta Ragghianti, Paolo Sbraccia, Dror Dicker   +11 more
wiley   +1 more source

Obesity Treatments and Weight Changes in Clinical Practice After Discontinuation of Semaglutide or Tirzepatide

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To describe obesity treatments in real‐world settings after discontinuation of semaglutide or tirzepatide and variability in weight change post‐discontinuation. Materials and Methods This retrospective cohort study used electronic health records from 1 January 2021, to 30 June 2025, in a large health system in Ohio and Florida.
Hamlet Gasoyan, Rebecca Schulte, Christopher B. Boyer, Nicholas J. Casacchia, W. Scott Butsch, Phuc Le, Ali Aminian, Marcio L. Griebeler, Bartolome Burguera, Michael B. Rothberg   +9 more
wiley   +1 more source