Results 41 to 50 of about 4,900 (222)

Investigating the KNDy hypothesis in humans by co-administration of kisspeptin, neurokinin B and naltrexone in men [PDF]

, 2016
Context: A subpopulation of hypothalamic neurons co-localise three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis);
Abbara, A, Bassett, P, Bloom, S, COMNINOS, A, Dhillo, WS, Jayasena, C, Mizamtsidi, M, Narayanaswamy, S, Papadopoulou, D, Prague, J, Shah, A, Veldhuis, J   +11 more
core   +1 more source

Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment

Frontiers in Immunology, 2021
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating multi-systemic chronic condition of unknown aetiology classified as an immune dysfunction syndrome and neurological disorder.
Helene Cabanas, Helene Cabanas, Katsuhiko Muraki, Katsuhiko Muraki, Natalie Eaton-Fitch, Natalie Eaton-Fitch, Donald Ross Staines, Donald Ross Staines, Sonya Marshall-Gradisnik, Sonya Marshall-Gradisnik   +9 more
doaj   +1 more source

Advances in oral transmucosal drug delivery [PDF]

, 2011
Original article can be found at : http://sciencedirect.com/ Copyright ElsevierThe successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity.
Brown, Marc, Liu, Fang, Patel, Viralkumar F.   +2 more
core   +1 more source

Design and Characterization of Spray-Dried Chitosan-Naltrexone Microspheres for Microneedle-Assisted Transdermal Delivery

Pharmaceutics, 2020
Naltrexone (NTX) hydrochloride is a potent opioid antagonist with significant first-pass metabolism and notable untoward effects when administered orally or intramuscularly. Microneedle (MN)-assisted transdermal delivery is an attractive alternative that
Abayomi T. Ogunjimi, Jennifer Fiegel, Nicole K. Brogden   +2 more
doaj   +1 more source

The Role of Neurotransmitters in Protection against Amyloid- β Toxicity by KiSS-1 Overexpression in SH-SY5Y Neurons. [PDF]

, 2013
Recent studies have suggested that the kisspeptin (KP) and kissorphin (KSO) peptides have neuroprotective actions against the Alzheimer's amyloid- β (A β ) peptide.
Chilumuri, A., Chilumuri, A., Milton, N.G.N., Milton, N.G.N.   +3 more
core   +6 more sources

Naltrexone Hydrochloride Loaded W/O Microemulsions: Preparation, Characterization and Exploring the Anti-leishmanial Activity

İstanbul Journal of Pharmacy
Emine Özyılmaz, Emrah Güler, Kaya Süer, Ahmet Özbilgin, İbrahim Çavuş, Tansel Çomoğlu   +5 more
openaire   +3 more sources

Chitosan/Poly(2-ethyl-2-oxazoline) films with ciprofloxacin for application in vaginal drug delivery [PDF]

, 2020
Chitosan (CHI) and chitosan/poly(2-ethyl-2-oxazoline) (CHI/POZ)-based films were prepared by casting from aqueous solutions of polymer blends with different compositions. Ciprofloxacin was used as a model drug in these formulations. The weight, thickness,
Abilova, Guzel K., Irmukhametova, Galiya S., Iskakbayeva, Zhanar A., Kaldybekov, Daulet B., Kazybayeva, Diara S., Khutoryanskiy, Vitaliy V., Kudaibergenov, Sarkyt E.   +6 more
core   +1 more source

Kinetic analysis of drug release from nanoparticles [PDF]

, 2008
PURPOSE. Comparative drug release kinetics from nanoparticles was carried out using conventional and our novel models with the aim of finding a general model applicable to multi mechanistic release.
Adibkia, Khosro, Barzegar-Jalali, Mohammad, Hasan, Maryam, Mohammadi, Ghobad, Nezhadi, Somayeh Hallaj, Nokhodchi, Ali, Omidi, Yadollah, Shadbad, Mohammad Reza Siahi, Valizadeh, Hadi   +8 more
core   +2 more sources

Assessing the Subjective and Physiological Effects of Intranasally Administered Crushed Extended-Release Morphine Formulations with and without a Sequestered Naltrexone Core in Recreational Opioid Users

Pain Research and Management, 2013
OBJECTIVE: To evaluate the pharmacodynamic (PD) effects of morphine sulfate and naltrexone hydrochloride extended-release (MSN) capsules compared with controlled-release morphine sulfate (MS) and placebo when crushed and administered intranasally.
Beatrice Setnik, Veeraindar Goli, Naama Levy-Cooperman, Catherine Mills, Megan Shram, Ira Smith   +5 more
doaj   +1 more source

Synthesis, biological evaluation, and SAR studies of 14β-phenylacetyl substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones derivatives : Ligands with mixed NOP and opioid receptor profile [PDF]

, 2018
© 2018 Kumar, Polgar, Cami-Kobeci, Thomas, Khroyan, Toll and Husbands.A series of 14β-acyl substituted 17-cyclopropylmethyl-7,8-dihydronoroxymorphinone compounds has been synthesized and evaluated for affinity and efficacy for mu (MOP), kappa (KOP), and ...
Cami-Kobeci, Champion, Cheng, Christoph, Ding, Dooley, Greedy, Greiner, Gumusel, Günther, Hu, Huang, Jenck, Khroyan, Khroyan, Kiguchi, Ko, Lewis, Lewis, Lia, Manabe, Meunier, Meunier, Mogil, Mollereau, Moynihan, Pomonis, Raffa, Reinsceid, Rizzi, Rossi, Saccone, Sandin, Schmidhammer, Schmidhammer, Schmidhammer, Spagnolo, Sukhtankar, Thompson, Toll, Toll, Traynor, Ueda, Vanderah, Váradi, Woodcock, Yu, Zeilhofer   +47 more
core   +4 more sources