Results 61 to 70 of about 4,900 (222)

Poloxamer-based thermoresponsive ketorolac tromethamine in situ gel preparations : design, characterisation, toxicity and transcorneal permeation studies [PDF]

, 2017
This study was aimed at preparing, characterising and evaluating in situ gel formulations based on a blend of two hydrophilic polymers i.e. poloxamer 407 (P407) and poloxamer 188 (P188) for a sustained ocular delivery of ketorolac tromethamine (KT). Drug-
Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abou El-elaa, Ajit, Al Khateb, Alany, Almeida, Amal K. Hussein, Angius, Anil Vangala, Asasutjarit, Attama, Auerbach, Baeyens, Baklayan, Baloglu, Chena, Dohle, Dumortier, El-Kamel, Faber, Fathalla, Fernández-Ferreiro, Garg, Gupta, Hao, Heilmann, Kadam, Khaled A. Khaled, Kim, Kim, Law, Li, Ling, Luepke, Mansour, Mayol, Michael Longman, Mosmann, Mythri, Nanjawade, Nanjwadea, Newa, Omar H. El-Garhy, Qi, Raid G. Alany, Riccia, Rooks, Rossi, Rupenthal, Rupenthala, Schoenwald, Sinha, Sintzel, Sunil, Thakor, Thrimawithana, Thrimawithanaa, Vadnere, Verstraelen, Walters, Wei, Weterings, Worakul, Xu, Yang, Zeinab M.A. Fathalla   +72 more
core   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

MedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu, Zhi‐Shan Ge, Qing‐Yue Cao, Zi‐Han Li, An Zhang, Hai‐Dong Zhu, Gao‐Jun Teng   +6 more
wiley   +1 more source

Pharmacoepidemiology of Oxycodone in the USA: An Observational Study of ARCOS, Medicaid, and Medicare Drug Databases

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT The US continues to battle an opioid crisis, substantially influenced by prescription opioids, with nearly 80 000 opioid‐related deaths in 2023. This study aims to characterize oxycodone's distribution in the United States (US) from 2000 to 2023 using three data sources.
Jay P. Solgama, Apoorva Pradhan, Kenneth L. McCall, Brian J. Piper   +3 more
wiley   +1 more source

Innovative Drug Delivery and Formulation Designs To Deter Drug Abuse/Misuse Related To Suicide [PDF]

, 2012
Patients with a history of abuse/misuse of pain and psychotic medications are at high risk for suicide. Novel drug delivery and formulation approaches have been explored to reduce the potential of drug abuse/misuse and to improve patient compliance. This
Zhao, Fang
core   +1 more source

Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva [PDF]

, 2019
Sublingual film dosage forms for drugs used for fast symptomatic treatment have promise because they allow a rapid onset of action. The aim of this study was to prepare films of silodosin intended for sublingual administration for the symptomatic ...
Adair, Alhayali, Allam, Alonzo, Boateng, Brady, Brouwers, Campisi, Chapple, Curatolo, De Caro, El-Setouhy, ElMeshad, Gao, Garsuch, Gittings, Guo, Hanif, Hobbs, Huang, Humphrey, Jug, Kalia, Kapoor, Kim, Koland, Korhonen, Li, Liew, Madhav, Mashru, Matsubara, Miller-Chou, Montorsi, Nagy, Patel, Prabhu, Prasad, Preis, Preis, Preis, Radebaugh, Repka, Rossi, Runja, Sharma, Singh, Singh, Singh, Singh, Slavkova, Tanno, Vila, Visser, Vuddanda, Vuddanda, Yang, Zhang   +57 more
core   +2 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Multi‐scale maternal behavioral responses by white‐tailed deer to coyote predation risk

The Journal of Wildlife Management, Volume 90, Issue 1, January 2026.
In the piedmont region of the southeastern US, white‐tailed deer adjust maternal care strategies in response to variation in risk of encountering coyotes. In areas frequented by coyotes, adult female deer (i.e., does) increase their use of space, likely to avoid drawing coyotes to the location where a fawn is hidden.
Michael S. Muthersbaugh, Wesley W. Boone, Elizabeth A. Saldo, Alex J. Jensen, Charles Ruth, Jay Cantrell, John C. Kilgo, David S. Jachowski   +7 more
wiley   +1 more source

Seroprevalence of Foot and Mouth Disease Virus Infection in Some Wildlife and Cattle in Bauchi State, Nigeria

Veterinary Medicine International, 2020
Foot and mouth disease (FMD) is an important transboundary viral disease of both domestic and wild cloven-hoofed animals characterized by high morbidity with devastating consequence on the livestock worldwide. Despite the endemic nature of FMD in Nigeria,
Y. J. Atuman, C. A. Kudi, P. A. Abdu, O. O. Okubanjo, A. Abubakar, Y. Wungak, H. G. Ularamu   +6 more
doaj   +1 more source

A Population Pharmacokinetic Model to Assess the Cytochrome P450 2B6 Metabolic Probe Bupropion and Hydroxybupropion in Vitamin D‐Insufficient and ‐Replete Patients With Kidney Disease

Journal of Clinical Pharmacy and Therapeutics, Volume 2026, Issue 1, 2026.
Objective The aim of this study was to use bupropion as a cytochrome P450 (CYP) 2B6 probe to determine CYP2B6 function by using a population pharmacokinetic approach of parent bupropion and metabolite hydroxybupropion to explore the impacts of chronic kidney disease (CKD) and vitamin D status in patients and control subjects.
Avisek Ghimire, Stacey M. Tuey, Linda Prebehalla, Amandla Atilano-Roque, Gavriel Roda, Lauren E. Thompson, Michel B. Chonchol, Nirav Shah, Michael F. Wempe, Thomas D. Nolin, Melanie S. Joy, Irina B. Bondareva   +11 more
wiley   +1 more source