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Results 71 to 80 of about 4,900 (222)

Combining Varenicline (Chantix) with Naltrexone Decreases Alcohol Drinking More Effectively Than Does Either Drug Alone in a Rodent Model of Alcoholism [PDF]

, 2016
Background This study examined whether varenicline (VAR), or naltrexone (NTX), alone or in combination, reduces alcohol drinking in alcohol-preferring (P) rats with a genetic predisposition toward high voluntary alcohol intake.
Dilley, Julian E. +6 more
core +4 more sources

The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors

British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source

Management of xylazine toxicity, overdose, dependence, and withdrawal: A systematic review

The American Journal on Addictions, Volume 34, Issue 6, Page 589-602, November 2025.
Abstract Background and Objectives Xylazine, an alpha‐2‐adrenergic agonist, has been increasingly implicated in substance use and overdose crises. However, little is known about its effects on humans. With the growing public health crisis surrounding xylazine, it has become important to recognize and promptly manage symptoms of xylazine toxicity ...
Philipa Owusu‐Antwi +4 more
wiley +1 more source

Heroin withdrawal as a possible cause of acute concomitant esotropia in adults [PDF]

, 2001
Aim: To report the possible effects of heroin withdrawal on binocular vision. Methods: To present a case series of patients in whom esotropia developed on cessation of heroin use.
Firth, A.Y.
core

Antinociceptive effects of morphine and naloxone in mu-opioid receptor knockout mice transfected with the MORS196A gene [PDF]

, 2010
Background Opioid analgesics such as morphine and meperidine have been used to control moderate to severe pain for many years. However, these opioids have many side effects, including the development of tolerance and dependence after long-term use, which
Shiou-Lan Chen +6 more
core +2 more sources

Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

Frontiers in Immunology, 2019
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a seriously long-term and debilitating illness of unknown cause hallmarked by chronic pain and fatigue, memory and concentration impairment, and inflammation.
Helene Cabanas +10 more
doaj +1 more source

Behavioral and pharmacological characterization of a mouse model of palatable diet alternation [PDF]

, 2017
Obesity and eating disorders represent a severe problem in Western societies. Both the increased availability of highly palatable foods and dieting are major risk factors contributing to the epidemic disorders of feeding. The purpose of this study was to
Schlain, Gabrielle Star
core

Molecular Mechanisms of Chronic Pain and Therapeutic Interventions

MedComm, Volume 6, Issue 8, August 2025.
We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li +8 more
wiley +1 more source

Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic–clonic seizures

Epilepsia Open, Volume 10, Issue 3, Page 880-893, June 2025.
Abstract Objective Evaluating the efficacy of an opioid antagonist, naloxone (NLX), to reduce the severity of post‐ictal hypoxemia and immobility after focal to bilateral tonic–clonic seizures (FBTCS). Methods ENALEPSY is a double‐blind placebo (PCB)‐controlled trial conducted in patients with focal epilepsy undergoing long‐term video‐EEG monitoring ...
Sylvain Rheims +71 more
wiley +1 more source

Longitudinal and Concurrent Changes in Brain and Gut due to Morphine Self‐Administration

Addiction Biology, Volume 30, Issue 6, June 2025.
With this work, we present evidence of longitudinal changes in the brain and gut microbiome following morphine use. We used a within‐subjects design to show that chronic administration of morphine alters 1) the striatum microstructure using MRI, 2) gut microbiome diversity derived from fecal samples, and 3) these changes are correlated to each other ...
Kaylee Brunetti +9 more
wiley +1 more source

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