Results 1 to 10 of about 15,085 (211)
Nicotinamide phosphoribosyltransferase in NAD+ metabolism: physiological and pathophysiological implications [PDF]
Cell Death DiscoveryNicotinamide adenine dinucleotide (NAD⁺) is a critical coenzyme involved in cellular metabolism, energy balance, and various physiological processes.
Weijia Zhang +7 more
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Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in differentiated PC12 cells [PDF]
PeerJ, 2021 Background. Multiple studies have indicated crucial roles of NAD+ deficiency in several neurological diseases and aging. It is critical to discover the mechanisms underlying the NAD+ deficiency. A decreased level of Nicotinamide phosphoribosyltransferase
Cuiyan Zhou, Weihai Ying
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Acta Pharmaceutica Sinica B, 2022 Nicotinamide phosphoribosyl transferase (NAMPT) is considered as a promising target for cancer therapy given its critical engagement in cancer metabolism and inflammation.
Ying Wu +5 more
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Hepatic Nampt Deficiency Aggravates Dyslipidemia and Fatty Liver in High Fat Diet Fed Mice
Cells, 2023 Nicotinamide phosphoribosyltransferase (Nampt) is the rate-limiting enzyme in the salvage pathway of nicotinamide adenine dinucleotide (NAD) biosynthesis.
Dao-Xin Wang +8 more
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NAMPT serum levels are selectively elevated in acute infectious disease and in acute relapse of chronic inflammatory diseases in children. [PDF]
PLoS ONE, 2017 Nicotinamide phosphoribosyl transferase (NAMPT) is an inflammatory adipocytokine shown to interact in immune modulation in chronic inflammatory diseases, acute respiratory distress syndrome, sepsis, cancer and obesity in adulthood.
Julia Gesing +7 more
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Antioxidants, 2022 Nicotinamide phosphoribosyl transferase (NAMPT) is required to maintain the NAD+ pool, among which extracellular (e) NAMPT is associated with inflammation, mainly mediated by macrophages.
Jae-Sung Kim +9 more
doaj +1 more source
Journal of Translational Medicine, 2022 Background Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD) biosynthesis, is up-regulated in several cancers, including metastatic melanoma (MM). The BRAF oncogene is mutated in different
Valentina Audrito +12 more
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It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]
, 2016 The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
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Cancer Biology & Therapy, 2023 Cisplatin resistance is a major therapeutic challenge in non-small cell lung cancer (NSCLC). Herein, the regulatory role of long non-coding RNA (lncRNA) ITGB2-AS1 in regulating NSCLC cisplatin resistance was investigated. NSCLC cisplatin resistance cells
Huiyong Chen +6 more
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Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the expression of nicotinamide phosphoribosyl transferase(NAMPT) in colon cancer tissues and analyze its physicochemical properties, secondary and tertiary structures, protein-protein interaction, subcellular localization and ...
TANG Jun, LIU Liming
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