Results 11 to 20 of about 15,085 (211)
Expression and regulation of nampt in human islets. [PDF]
PLoS ONE, 2013 Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enzyme in the mammalian NAD+ biosynthesis of a salvage pathway and exists in 2 known forms, intracellular Nampt (iNampt) and a secreted form, extracellular Nampt (eNampt).
Karen Kover +11 more
doaj +3 more sources
Visfatin/Nampt: An Adipokine with Cardiovascular Impact [PDF]
Mediators of Inflammation, 2013 Adipose tissue is acknowledged as an endocrine organ that releases bioactive factors termed adipokines. Visfatin was initially identified as a novel adipokine with insulin-mimetic properties in mice.
Tania Romacho +2 more
doaj +4 more sources
NAD<sup>+</sup> Homeostasis Attenuates Japanese Encephalitis Virus Infection Progression. [PDF]
FASEB JJEV infection in brain tissue triggers inflammation and stress in neuronal cells, leading to NAD+ depletion via the overactivation of PARPs and SIRTs. While compensatory biosynthetic pathways (de novo and salvage) were upregulated, the NAD+ level fell critically. In vitro NAMPT inhibition exacerbates this deficit and viral load.
Kassegn TA +10 more
europepmc +2 more sources
NAMPT (nicotinamide phosphoribosyltransferase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on NAMPT (nicotinamide phosphoribosyltransferase), with data on DNA, on the protein encoded, and where the gene is implicated.
Koumaki, V, Dalamaga, M
openaire +2 more sources
Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Hepatology, EarlyView., 2022 Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández +18 more
wiley +1 more source
Nampt/PBEF/visfatin and cancer [PDF]
Cancer Biology & Therapy, 2010 Nampt/PBEF/visfatin is the rate-limiting enzyme that catalyzes the first step in NAD biosynthesis from nicotinamide and regulates growth, apoptosis and angiogenesis of mammalian cells. This enzyme was originally cloned as a putative cytokine shown to enhance the B cell precursor maturation in the presence of IL-7 and stem cell factor.
Tie-qiang, Bi, Xiang-ming, Che
openaire +2 more sources
Correction: Epigenetic Regulation of NAMPT by NAMPT-AS Drives Metastatic Progression in Triple-Negative Breast Cancer [PDF]
Cancer Research, 2021 Triple-negative breast cancer (TNBC) is highly heterogeneous and has a poor prognosis. It is therefore important to identify the underlying molecular mechanisms in order to develop novel therapeutic strategies. Although emerging research has revealed long noncoding RNAs (lncRNA) as vital to carcinogenesis and cancer progression, their functional ...
Hanwen, Zhang +18 more
openaire +2 more sources
Nicotinamide phosphoribosyl transferase (Nampt) is a target of microRNA-26b in colorectal cancer cells. [PDF]
PLoS ONE, 2013 A number of cancers show increased expression of Nicotinamide phosphoribosyl transferase (Nampt). However, the mechanism through which Nampt is upregulated is unclear.
Chenpeng Zhang, Jinlu Tong, Gang Huang
doaj +1 more source
Frontiers in Immunology, 2022 Metabolic intervention is a novel anti-rheumatic approach. The glycolytic regulator NAMPT has been identified as a therapeutic target of rheumatoid arthritis (RA), while other metabolic regulators coordinating NAMPT to perpetuate inflammation are yet to ...
Ming Lei +13 more
doaj +1 more source
MicroRNA410 Inhibits Pulmonary Vascular Remodeling via Regulation of Nicotinamide Phosphoribosyltransferase [PDF]
, 2019 Nicotinamide phosphoribosyltransferase (NAMPT) upregulation in human pulmonary artery endothelial cells (hPAECs) is associated with pulmonary arterial hypertension (PAH) progression and pulmonary vascular remodeling.
Chen, Jiwang +7 more
core +1 more source