Results 51 to 60 of about 15,085 (211)

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion [PDF]

, 2016
Overexpression of the NAD(+) biosynthetic enzyme NMNAT1 leads to preservation of injured axons. While increased NAD(+) or decreased NMN levels are thought to be critical to this process, the mechanism(s) of this axon protection remain obscure.
Araki, Babetto, Coleman, Conforti, Di Stefano, Elliott, Gerdts, Gerdts, Gerdts, Gerdts, Gilley, Gilley, Hara, Hikosaka, Lois, Mack, Osterloh, Revollo, Sasaki, Sasaki, Sasaki, Sasaki, Szretter, Wang, Wang   +24 more
core   +3 more sources

Epigenetic Regulation of NAMPT by NAMPT-AS Drives Metastatic Progression in Triple-Negative Breast Cancer [PDF]

Cancer Research, 2019
Abstract Triple-negative breast cancer (TNBC) is highly heterogeneous and has a poor prognosis. It is therefore important to identify the underlying molecular mechanisms in order to develop novel therapeutic strategies.
Hanwen, Zhang, Ning, Zhang, Ying, Liu, Peng, Su, Yiran, Liang, Yaming, Li, Xiaolong, Wang, Tong, Chen, Xiaojin, Song, Yuting, Sang, Yi, Duan, Jiashu, Zhang, Lijuan, Wang, Bing, Chen, Wenjing, Zhao, Haiyang, Guo, Zhaojian, Liu, Guohong, Hu, Qifeng, Yang   +18 more
openaire   +2 more sources

NAMPT Inhibition Induces Neuroblastoma Cell Death and Blocks Tumor Growth

Frontiers in Oncology, 2022
High-risk neuroblastoma (NB) portends very poor prognoses in children. Targeting tumor metabolism has emerged as a novel therapeutic strategy. High levels of nicotinamide-adenine-dinucleotide (NAD+) are required for rapid cell proliferation. Nicotinamide
Frederic A. Vallejo, Anthony Sanchez, Anthony Sanchez, Branko Cuglievan, Branko Cuglievan, Winston M. Walters, Guillermo De Angulo, Steven Vanni, Steven Vanni, Steven Vanni, Regina M. Graham, Regina M. Graham   +11 more
doaj   +1 more source

Sirtuin functions and modulation: from chemistry to the clinic [PDF]

, 2016
Sirtuins are NAD+ -dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell ...
Altucci, Lucia, Carafa, Vincenzo, Cuomo, Francesca, Forgione, Mariantonietta, Hailu, GEBREMEDHIN SOLOMON, Jarho, Elina, Lahtela Kakkonen, Maija, Mai, Antonello, Rotili, Dante, Serretiello, Enrica   +9 more
core   +2 more sources

Targeting NAMPT as a therapeutic strategy against stroke [PDF]

Stroke and Vascular Neurology, 2019
Stroke is the second and the leading most common cause of death in the world and China, respectively, but with few effective therapies. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme for nicotinamide adenine dinucleotide (NAD) salvage synthesis in mammals, thereby influencing NAD-dependent enzymes and constituting a strong ...
Shu-Na Wang, Chao-Yu Miao
openaire   +2 more sources

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

NAD+ metabolism controls inflammation during senescence

Molecular & Cellular Oncology, 2019
We have recently discovered that nicotinamide adenine dinucleotide metabolism controls the pro-inflammatory senescence-associated secretory phenotype during cellular senescence.
Timothy Nacarelli, Rugang Zhang
doaj   +1 more source

AMPK phosphorylates NAMPT to regulate NAD+ homeostasis under ionizing radiation

Open Biology, 2022
Radiation-induced oral mucositis is the most common complication for patients who receive head/neck radiotherapy. Nicotinamide adenine dinucleotide (NAD+) is vital for DNA damage repair under ionizing radiation, through functioning as either the ...
Xiaoyu Liao, Xiaoke Huang, Xin Li, Xuemei Qiu, Mi Li, Rui Liu, Tao He, Qingfeng Tang   +7 more
doaj   +1 more source

Dysregulation of NAD+ metabolism induces a Schwann cell dedifferentiation program [PDF]

, 2018
The Schwann cell (SC) is the major component of the peripheral nervous system (PNS) that provides metabolic and functional support for peripheral axons. The emerging roles of SC mitochondrial function for PNS development and axonal stability indicate the
Hackett, Amber R, Kim, Sungsu, Milbrandt, Jeffrey, Sasaki, Yo, Strickland, Amy   +4 more
core   +1 more source

Crystal structure-based comparison of two NAMPT inhibitors [PDF]

Acta Pharmacologica Sinica, 2017
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is a novel strategy for cancer therapy, but only two inhibitors of NAMPT (FK866 and CHS828) have progressed into clinical trials. This study seeks to compare a novel potent NAMPT inhibitor, MS0, with a classical inhibitor FK866 in their biological activity and molecular binding mode, thereby ...
Sai-Long, Zhang, Tian-Ying, Xu, Zhen-Lin, Yang, Shuo, Han, Qiang, Zhao, Chao-Yu, Miao   +5 more
openaire   +2 more sources