Results 81 to 90 of about 15,085 (211)

Altered clock gene expression in obese visceral adipose tissue is associated with metabolic syndrome [PDF]

, 2017
Clock gene expression was associated with different components of metabolic syndrome (MS) in human adipose tissue. However, no study has been done to compare the expression of clock genes in visceral adipose tissue (VAT) from lean and obese subjects and ...
Aranda, Gloria, Carmona Herrera, Francisco, Figueroa, Ana Lucia, Gomis, Ramon, 1946-, Hanzu, Felicia A., Momblan, Dulce, Ruano, Elena G., Vidal i Cortada, Josep, Vieira, Elaine   +8 more
core   +1 more source

A microdeletion in Alzheimer’s disease disrupts NAMPT gene [PDF]

Journal of Genetics, 2014
c Indian Academy of Sciences RESEARCH NOTE A microdeletion in Alzheimer’s disease disrupts NAMPT gene DARINE VILLELA 1 , DAVID SCHLESINGER 2 , CLAUDIA K. SUEMOTO 3 , LEA T. GRINBERG 3,4 and CARLA ROSENBERG 1 ∗ Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of Sao Paulo, Rua do Matao 277, 05508-090, Sao Paulo ...
Villela, D, Schlesinger, D, Suemoto, CK, Grinberg, LT, Rosenberg, C   +4 more
openaire   +4 more sources

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, EarlyView.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source

Stimulation of MMP-1 and CCL2 by NAMPT in PDL Cells

Mediators of Inflammation, 2013
Periodontitis is an inflammatory disease caused by pathogenic microorganisms and characterized by the destruction of the periodontium. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of adipokines, such as ...
Marjan Nokhbehsaim, Sigrun Eick, Andressa Vilas Boas Nogueira, Per Hoffmann, Stefan Herms, Holger Fröhlich, Søren Jepsen, Andreas Jäger, Joni Augusto Cirelli, James Deschner   +9 more
doaj   +1 more source

Inhibition of NAMPT by PAK4 Inhibitors

International Journal of Molecular Sciences
The serine/threonine kinase PAK4 plays a crucial role in regulating cell proliferation, survival, migration, and invasion. Overexpression of PAK4 correlates with poor prognosis in some cancers. KPT-9274, a PAK4 inhibitor, significantly reduces the growth of triple-negative breast cancer cells and mammary tumors in mouse models, and it also inhibits the
Yiling Wang, Audrey Minden
openaire   +2 more sources

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. [PDF]

PLoS ONE, 2014
Nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme for nicotinamide adenine dinucleotide (NAD+) synthesis, and Sirt1, an NAD+-dependent histone deacetylase, protect the heart against ischemia/reperfusion (I/R).
Takanobu Yamamoto, Jaemin Byun, Peiyong Zhai, Yoshiyuki Ikeda, Shinichi Oka, Junichi Sadoshima   +5 more
doaj   +1 more source

Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity [PDF]

, 2011
BACKGROUND AND AIMS: Nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine with physiological effects on the control of glucose homeostasis as well as potentially involved in inflammation.
Catalan, V. (Victoria), Frühbeck, G. (Gema), Gomez-Ambrosi, J. (Javier), Ramirez, B. (Beatriz), Rodriguez, A. (Amaia), Rotellar, F. (Fernando), Salvador, J. (Javier), Silva, C. (Camilo), Álvarez-Cienfuegos, J. (Javier)   +8 more
core  

Expression of nampt in hippocampal and cortical excitatory neurons is critical for cognitive function [PDF]

, 2014
Nicotinamide adenine dinucleotide (NAD(+)) is an enzyme cofactor or cosubstrate in many essential biological pathways. To date, the primary source of neuronal NAD(+) has been unclear.
Apte, Rajendra S, Dearborn, Joshua T, Imai, Shin-ichiro, Izumi, Yukitoshi, Kubota, Shunsuke, Stein, Liana Roberts, Wozniak, David F, Zorumski, Charles F   +7 more
core   +2 more sources

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source