Results 131 to 140 of about 19,829 (313)

Review of studies in field of the effects of nanotechnology on breast cancer [PDF]

arXiv, 2018
Cancer is the main cause of mortality at the developed countries and is the second cause of mortality at the developing countries and breast cancer is the most prevalent malignancy and the first cause of mortality among women of the world. At the US, 28% of new cancer cases and 15% of mortality caused by that in 2010 was caused by breast cancer ...
arxiv  

Circulating tumor cells share RNA modules with early embryo trophectoderm and with metastatic cancer

Cancer Communications, EarlyView.
Stefano Volinia, Anna Terrazzan, Tomasz S. Kaminski, Krystian Jadzewski, Eva Reali, Nicoletta Bianchi, Jeff Palatini   +6 more
wiley   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Mesoscale computational protocols for the design of highly cooperative bivalent macromolecules [PDF]

arXiv, 2019
The last decade has witnessed a swiftly increasing interest in the design and production of novel multivalent molecules as powerful alternatives for conventional antibodies in the fight against cancer and infectious diseases. However, while it is widely accepted that large-scale flexibility ($10-100$ nm) and free/constrained dynamics (100 ns $- \mu$s ...
arxiv  

The ALFA-tag is a highly versatile tool for nanobody-based bioscience applications

Nature Communications, 2019
Specialized epitope tags are widely used for detecting, manipulating or purifying proteins, but often their versatility is limited. Here, we introduce the ALFA-tag, a rationally designed epitope tag that serves a remarkably broad spectrum of applications
H. Götzke, Markus Kilisch, M. Martínez-Carranza, Shama Sograte-Idrissi, A. Rajavel, Thomas Schlichthaerle, N. Engels, R. Jungmann, P. Stenmark, F. Opazo, Steffen Frey   +10 more
semanticscholar   +1 more source

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Production of a mono-biotinylated EGFR nanobody in the E. coli periplasm using the pET22b vector

BMC Research Notes, 2018
Objective Our aim was to produce a mono-biotinylated single domain antibody (‘nanobody’) specific for the epidermal growth factor receptor (EGFR), which is overexpressed in many cancer cells.
Alfiah Noor, Gudrun Walser, Matthijs Wesseling, Philippe Giron, Albert-Menno Laffra, Fatima Haddouchi, Jacques De Grève, Peter Kronenberger   +7 more
doaj   +1 more source

Integrative Modeling in the Age of Machine Learning: A Summary of HADDOCK Strategies in CAPRI Rounds 47–55

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The HADDOCK team participated in CAPRI rounds 47–55 as server, manual predictor, and scorers. Throughout these CAPRI rounds, we used a plethora of computational strategies to predict the structure of protein complexes. Of the 10 targets comprising 24 interfaces, we achieved acceptable or better models for 3 targets in the human category and 1 ...
Victor Reys, Marco Giulini, Vlad Cojocaru, Anna Engel, Xiaotong Xu, Jorge Roel‐Touris, Cunliang Geng, Francesco Ambrosetti, Brian Jiménez‐García, Zuzana Jandova, Panagiotis I. Koukos, Charlotte van Noort, João M. C. Teixeira, Siri C. van Keulen, Manon Réau, Rodrigo V. Honorato, Alexandre M. J. J. Bonvin   +16 more
wiley   +1 more source

AlphaFold and Docking Approaches for Antibody–Antigen and Other Targets: Insights From CAPRI Rounds 47–55

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Accurate modeling of the structures of protein–protein complexes and other biomolecular interactions represents a longstanding and important challenge for computational biology. The Critical Assessment of PRedicted Interactions (CAPRI) experiment has served for over two decades as a key means to assess and compare current approaches and ...
Ragul Gowthaman, Minjae Park, Rui Yin, Johnathan D. Guest, Brian G. Pierce   +4 more
wiley   +1 more source

Massive Sampling Strategy for Antibody–Antigen Targets in CAPRI Round 55 With MassiveFold

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Massive sampling with AlphaFold2 improves protein–protein complex predictions. This has been shown during the last CASP15‐CAPRI blind prediction round by the AFsample tool. However, more difficult targets including antibody–antigen binding remain challenging. CAPRI Round 55 consisted of three antibody–antigen targets and one heterotrimer.
Nessim Raouraoua, Marc F. Lensink, Guillaume Brysbaert   +2 more
wiley   +1 more source