Results 131 to 140 of about 12,492 (212)

Effect of Interleukin‐6 Inhibitors on Rheumatoid Arthritis Pain: Overview of Evidence and Mechanistic Pathways

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
This review synthesizes current mechanistic and clinical evidence on IL‐6 inhibitors, particularly sarilumab and tocilizumab, concerning their effect on pain in RA. ABSTRACT Rheumatoid arthritis (RA) is an autoimmune systemic disease in which pain remains a major and often refractory symptom even after clinical remission of the disease.
Andrej Belančić, Seher Sener, Almir Fajkić, Ines Potočnjak, Mirjana Stanić Benić, Marijana Vučković, Yusuf Ziya Sener, Marija Rogoznica Pavlović, Antonio Markotić, Josipa Radić, Mislav Radić   +10 more
wiley   +1 more source

Harnessing Autonomous AI Agents for the Next Generation of Scientific Discovery

SmartMat, Volume 7, Issue 2, April 2026.
The complexity of interdisciplinary coordination often stifles materials innovation. This comment discusses a transformative autonomous AI Virtual Lab where agents collaborate and orchestrate computational tools via code generation. Adapted for materials science, this multi‐agent framework offers a blueprint for accelerating the discovery of complex ...
Qian Zhang, Zhiyao Su, Yajing Sun
wiley   +1 more source

Analytical Performance of Nanobody-Based Immunoassay and Immunosensing Platforms for Bacteria and Toxin Detection: A Systematic Review. [PDF]

Antibodies (Basel)
Jalil A, Touil N, Nyabi O, El Fahime E, Benlhachemi S, Gala JL, Ennibi K, Bakkouri K, Benjouad A, Belayachi L.   +9 more
europepmc   +1 more source

pH‐Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Pancreatic ductal adenocarcinoma (PDAC) develops within a uniquely dynamic pH landscape shaped by substantial acid–base fluxes produced by the exocrine pancreas. Secretion of alkaline pancreatic juice, normally linked to digestion, produces intermittent acidifications of the pancreatic interstitium, which challenges epithelial and stromal ...
Albrecht Schwab, Micol Rugi, Pawel Swietach, Wiktoria Błaszczak, Ivana Novak, Ganga Deshar, Stine Falsig Pedersen, Renata Ialchina, Albin Sandelin, Jiayi Yao, Stephan J. Reshkin, Rosa A. Cardone, Tiago M. A. Carvalho, Annarosa Arcangeli, Rayhana Bouazzi, Franco N. D'Alessandro, Natalia Prevarskaya, Madelaine M. Audero, Halima Ouadid‐Ahidouch, Julie Schnipper, Luis A. Pardo, Xiaoyi Shi, Frauke Alves, Jakub Mitręga, Anna Trauzold, Sofie E. Hagelund, György Panyi, Marco Cozzolino, Clemens M. W. G. Löwik, Laura Mezzanotte, Roisin McMorrow, Andreas Pahl, Torsten Hechler, Elena Papacharisi, Alessandra Fiorio Pla, Ildiko Szabo, Verena Hofschröer, Zoltán Pethő   +37 more
wiley   +1 more source

Nanobody tools [PDF]

Nature Methods, 2016
openaire   +1 more source

The TaMADS2‐TaTBL21 Module Enhances Wheat Resistance to Stripe Rust by Activating TaGKL‐Mediated Immunity

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2153-2168, April 2026.
ABSTRACT Wheat stripe rust (Puccinia striiformis f. sp. tritici, Pst) poses a catastrophic threat to global food security. While MADS‐box transcription factors regulate development and abiotic stress, their roles in plant‐pathogen immunity remain enigmatic.
Shijia Zhao, Hao Chu, Yanan Lu, Jiaqi Chen, Xu Wang, Guangxiang Tian, Mingjing Zhang, Pengyu Song, Yanhui Zhang, Guihua Bai, Gangming Zhan, Zhensheng Kang, Wenming Zheng, ZhengQing Fu, Na Liu   +14 more
wiley   +1 more source

<i>Alpseq</i>: an open-source workflow to turbocharge nanobody discovery with high-throughput sequencing. [PDF]

MAbs
Zeglinski K, Schuster J, Sa JD, Adair A, Deng J, Pymm P, Ritchie ME, Bowden R, Tham WH, Gouil Q.   +9 more
europepmc   +1 more source

TaPHL7 Transcription Factor Regulates Utilisation of Nitrogen and Phosphorus in Wheat

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2522-2537, April 2026.
ABSTRACT Macronutrients nitrogen and phosphorus are essential for plant growth and development, thus being crucial for the productivity of crops. However, the molecular mechanism regulating the utilisation of nitrogen and phosphorus remains elusive. Here, we show that the wheat (Triticum aestivum L.) transcription factor PHOSPHATE STARVATION RESPONSE ...
Huali Wang, Zhiyong Zhang, Yafei Guo, Qing Wang, Xiaochun Wang, Xiaohui Ma, Jinqiang Nian, Shuping Xiong, Xinbo Lin, Yingyin Yao, Zhongfu Ni, Fei Lu, Jianru Zuo, Xinming Ma   +13 more
wiley   +1 more source

Exploring Trop-2-Nanobody PPI Interactions through Molecular Dynamics Simulations and Biovalidations. [PDF]

ACS Omega
Cheng J, Sun ZY, Guo Z, Hao Y, Hou G, Li Y, Wang Y, Feng Z, Xue Y, Meng L.   +9 more
europepmc   +1 more source

Auxin‐Induced Nicotine Inhibition Is Mediated by NaARF5 Through the Suppression of NaERF1‐Like Expression and Interaction With NaERF1‐Like in Nicotiana attenuata

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2642-2656, April 2026.
ABSTRACT Nicotine is the most abundant alkaloid produced by Nicotiana species against insect herbivores. Although it has been known for decades that auxin can strongly inhibit nicotine biosynthesis, the underlying mechanisms have remained unclear.
Miyun Yang, Ahui Tong, Lei Wang, Jinsong Wu   +3 more
wiley   +1 more source