Results 151 to 160 of about 19,829 (313)

Comparison of the Biodistribution and Tumor Targeting of Two ^99mTc-Labeled Anti-EGFR Nanobodies in Mice, Using Pinhole SPECT/Micro-CT [PDF]

, 2008
Lea Olive Tchouate Gainkam, Lieven Huang, Vicky Caveliers, Marleen Keyaerts, Sophie Hernot, Ilse Vaneycken, Christian Vanhove, Hilde Revets, Patrick De Baetselier, Tony Lahoutte   +9 more
openalex   +1 more source

Microscopy and spectroscopy approaches to study GPCR structure and function

British Journal of Pharmacology, EarlyView.
Abstract The GPCR signalling cascade is a key pathway responsible for the signal transduction of a multitude of physical and chemical stimuli, including light, odorants, neurotransmitters and hormones. Understanding the structural and functional properties of the GPCR cascade requires direct observation of signalling processes in high spatial and ...
Tomáš Fessl, Maria Majellaro, Alexey Bondar   +2 more
wiley   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, EarlyView.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

APPLYING NANOBODY PHAGE DISPLAY TECHNOLOGY TO DISTINGUISH BETWEEN Brucella AND Yersinia LIPOPOLYSACCHARIDES استخدام تقنیة الفاجات العارضة للأضداد النانویة فی التمییز بین متعدد السکارید اللبیدی للبروسیلا والیرسینیا [PDF]

, 2010
Alia Naoufi, Abeer Khdrawi, Ayman Al-Mariri, Ahlam Mourad, Abdul Qader Abbady   +4 more
openalex   +1 more source

Arrestin‐centred interactions at the membrane and their conformational determinants

British Journal of Pharmacology, EarlyView.
Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood, Raphael Silvanus Haider, Julie Sanchez, Meritxell Canals   +3 more
wiley   +1 more source

Nanobodies

Molecular and Cellular Endocrinology, 2019
The family of G protein-coupled receptors (GPCRs) is the largest class of membrane proteins and an important drug target due to their role in many (patho)physiological processes. Besides small molecules, GPCRs can be targeted by biologicals including antibodies and antibody fragments.
De Groof, Timo, Bobkov, Vladimir, Heukers, Raimond, Smit, Martine J   +3 more
openaire   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

The path to the G protein‐coupled receptor structural landscape: Major milestones and future directions

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel, Zeenat Zara, Alessandro Nicoli, Alexandra Steuer, Marta Lopez‐Balastegui, Jana Selent, Sanjai Karanth, Melanie Koehler, Antonella Ciancetta, Layara Akemi Abiko, Franz Hagn, Antonella Di Pizio   +11 more
wiley   +1 more source

Opportunities to Modulate Tumor Ecosystem Toward Successful Glioblastoma Immunotherapy

Cancer Science, EarlyView.
There remain outstanding gaps between the negative results from clinical trials and the actual potential of the immune system for glioblastoma. To bridge this crucial gap, we collaborated with Dr. Mariko Takahashi, an expert in immunobiology and drug development, and Dr. James J.
Mariko Takahashi, Darina Mukhamejanova, Himani Jasewicz, Nandini Acharya, James J. Moon, Toshiro Hara   +5 more
wiley   +1 more source

A comparison of super‐resolution microscopy techniques for imaging tightly packed microcolonies of an obligate intracellular bacterium

Journal of Microscopy, EarlyView.
Abstract Conventional optical microscopy imaging of obligate intracellular bacteria is hampered by the small size of bacterial cells, tight clustering exhibited by some bacterial species and challenges relating to labelling such as background from host cells, a lack of validated reagents, and a lack of tools for genetic manipulation.
Alison J. North, Ved P. Sharma, Christina Pyrgaki, John Lim S.Y., Sharanjeet Atwal, Kittirat Saharat, Graham D. Wright, Jeanne Salje   +7 more
wiley   +1 more source