Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Accurate modeling of the structures of protein–protein complexes and other biomolecular interactions represents a longstanding and important challenge for computational biology. The Critical Assessment of PRedicted Interactions (CAPRI) experiment has served for over two decades as a key means to assess and compare current approaches and ...
Ragul Gowthaman +4 more
wiley +1 more source
Transient Multivalent Nanobody Targeting to CD206-Expressing Cells via PH-Degradable Nanogels [PDF]
, 2020 Maximilian Scherger +10 more
openalex +1 more source
Half-Life Extended Nanobody-Based CD38-Specific Bispecific Killercell Engagers Induce Killing of Multiple Myeloma Cells [PDF]
, 2022 Julia Hambach +7 more
openalex +1 more source
Massive Sampling Strategy for Antibody–Antigen Targets in CAPRI Round 55 With MassiveFold
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Massive sampling with AlphaFold2 improves protein–protein complex predictions. This has been shown during the last CASP15‐CAPRI blind prediction round by the AFsample tool. However, more difficult targets including antibody–antigen binding remain challenging. CAPRI Round 55 consisted of three antibody–antigen targets and one heterotrimer.
Nessim Raouraoua +2 more
wiley +1 more source
A Single-Domain VNAR Nanobody Binds with High-Affinity and Selectivity to the Heparin Pentasaccharide Fondaparinux [PDF]
Martha Gschwandtner +11 more
openalex +1 more source
A Nanobody-horseradish Peroxidase Fusion Protein-based Competitive ELISA for Rapid Detection of Antibodies Against Porcine Circovirus Type 2 [PDF]
, 2020 Yang Mu +8 more
openalex +1 more source
Evaluation of antidiphtheria toxin nanobodies
Nanotechnology, Science and Applications, 2010 Nanobodies are the smallest fragments of naturally occurring single-domain antibodies that have evolved to be fully functional in the absence of a light chain. Conventional antibodies are glycoproteins comprising two heavy and two light chains. Surprisingly, all members of the Camelidae family possess a fraction of antibodies devoid of both light ...
openaire +5 more sources
Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink +5 more
wiley +1 more source
Nanobody-Based ImmunoPET for Hepatocellular Carcinoma [PDF]
, 2023 Stanley Fayn +14 more
openalex +1 more source
Performance of pyDock in 8th CAPRI: Energy‐Based Scoring Applied to Docking and AlphaFold Models
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The 8th CAPRI edition has shown a significant evolution in the field of protein–protein complex structure prediction. We have participated in all 11 targets proposed in this edition, involving domain‐domain, protein–protein, protein‐peptide, and protein‐DNA interactions, including homo‐ and hetero‐meric interfaces.
Luis Angel Rodríguez‐Lumbreras +5 more
wiley +1 more source