Results 171 to 180 of about 16,593 (260)

Protein binding assessment of immobilized nanobody using interferometric nanoporous platform

VIEW, EarlyView.
Nanoporous anodic alumina photonic chip technology is combined with tailor‐engineered “nanobodies”—recombinant variable domains of heavy‐chain‐only antibodies—to achieve high affinity binding to human serum albumin. Abstract Protein sensors are key tools for infectious disease diagnosis and monitoring.
Cheryl Suwen Law, Jayden Revink, Joel Lee, Juan Wang, Andrew D. Abell, Fiona Whelan, Abel Santos   +6 more
wiley   +1 more source

Engineering nucleotide‐binding leucine‐rich repeat immune receptors to achieve broad‐spectrum disease resistance in plants

New Plant Protection, EarlyView.
Yan Wang, Yuzhen Mei, Fangfang Li
wiley   +1 more source

Nanobody–chlorin e6 conjugate for Nectin‐4‐mediated tumor targeting and enhanced photodynamic therapy

VIEW, EarlyView.
Nectin‐4 is frequently overexpressed in solid tumors, yet many PDT photosensitizers show poor water solubility and nonspecific uptake. A Nectin‐4‐targeted nanobody–chlorin e6 conjugate (NPC) improves aqueous solubility and selectively accumulates in Nectin‐4‐positive tumor cells.
Haodian Wan, Tao Ye, Yawei Bi, Jiayu Zhang, Wei Wu, Aochi Liu, Li Sun, Jie Lin, Ningli Chai, Manjie Zhang, Jian Ma   +10 more
wiley   +1 more source

A Camelid-Derived STAT-Specific Nanobody Inhibits Neuroinflammation and Ameliorates Experimental Autoimmune Encephalomyelitis (EAE) [PDF]

Evaristus C. Mbanefo, A. Seifert, Manoj Kumar Yadav, Cheng‐Rong Yu, Vijayaraj Nagarajan, Ashutosh S. Parihar, Sunanda Singh, Charles E. Egwuagu   +7 more
openalex   +1 more source

Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation

The FEBS Journal, EarlyView.
Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev, Tomas Obsil, Veronika Obsilova   +2 more
wiley   +1 more source

Current status and future expectations of nanobodies in oncology trials [PDF]

, 2023
Tessa De Pauw, Lynn De Mey, Jens Debacker, Geert Raes, Jo A. Van Ginderachter, Timo W.M. De Groof, Nick Devoogdt   +6 more
openalex   +1 more source

A comparison of super‐resolution microscopy techniques for imaging tightly packed microcolonies of an obligate intracellular bacterium

Journal of Microscopy, EarlyView.
Abstract Conventional optical microscopy imaging of obligate intracellular bacteria is hampered by the small size of bacterial cells, tight clustering exhibited by some bacterial species and challenges relating to labelling such as background from host cells, a lack of validated reagents, and a lack of tools for genetic manipulation.
Alison J. North, Ved P. Sharma, Christina Pyrgaki, John Lim S.Y., Sharanjeet Atwal, Kittirat Saharat, Graham D. Wright, Jeanne Salje   +7 more
wiley   +1 more source

Imaging malaria parasites across scales and time

Journal of Microscopy, EarlyView.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source

Na-no-body

BioéthiqueOnline, 2016
Ink on paper, wire, batteries, electroluminescent diodes, Petri dishes, silicone.
Coleman, Stephanie E.M.
doaj  

Review of expansion microscopy combined with advanced imaging modalities

Journal of Microscopy, EarlyView.
Abstract Expansion microscopy (ExM) is a powerful high‐resolution imaging technique that enhances the spatial resolution of conventional light microscopy by physically enlarging biological specimens by embedding and cross‐linking them in a swellable polymer network.
Natalie Woo, Claire M. Brown
wiley   +1 more source