Results 191 to 200 of about 19,829 (313)

High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis

, 2011
Benoı̂t Stijlemans, Guy Caljon, Senthil Natesan, Dirk Saerens, Katja Conrath, David Pérez‐Morga, Jeremy N. Skepper, Alexandros Nikolaou, Lea Brys, Étienne Pays, Stefan Magez, Mark C. Field, Patrick De Baetselier, Serge Muyldermans   +13 more
openalex   +2 more sources

Delivery of a functional anti-trypanosome Nanobody in different tsetse fly tissues via a bacterial symbiont, Sodalis glossinidius [PDF]

, 2014
Linda De Vooght, Guy Caljon, Karin De Ridder, Jan Van Den Abbeele   +3 more
openalex   +1 more source

Use of the single cell gel electrophoresis (comet assay) for comparing apoptotic effect of conventional antibodies versus nanobodies

, 2011
Ghada H. Shaker, Nahla A. Melake
openalex   +1 more source

Selection by phage display of nanobodies directed against hypoxia inducible factor‐1α (HIF‐1α) [PDF]

, 2014
Li M, Xiaodan Fan, Jing Liu, Yaozhong Hu, He Huang   +4 more
openalex   +1 more source

Dual‐Targeted Protein MRI Contrast Agent for Early Detection of Micrometastases

Aggregate, Volume 6, Issue 4, April 2025.
We have developed a dual‐target protein MRI contrast agent (EPR‐DTPA‐Gd) exhibits high r1 relaxivity 68.76 mM−1 s−1 per molecule and an improved pharmacokinetics behavior, achieving a widened time window for tumor imaging. Besides, EPR‐DTPA‐Gd successfully detected a metastasis with an area of 213 µm × 58 µm (0.012 mm2), which cannot be detected by the
Ruofan Hu, Zhiyang Wang, Tinghui Shen, Qianwen Yang, Weizhi Chen, Xiqun Jiang   +5 more
wiley   +1 more source

Correction: Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies

, 2012
Guy Caljon, Benoı̂t Stijlemans, Dirk Saerens, Jan Van Den Abbeele, Serge Muyldermans, Stefan Magez, Patrick De Baetselier   +6 more
openalex   +2 more sources

Experimental Approaches to Visualize Effector Protein Translocation During Host‐Pathogen Interactions

BioEssays, Volume 47, Issue 4, April 2025.
Translocation of effector proteins is a key virulence trait of many pathogenic bacteria. Various strategies were developed to visualize the translocation of effector proteins, and this review summarizes experimental approaches for analyses of translocation towards localization, kinetics, and dynamics on single molecule level.
Verena Nadin Fritsch, Michael Hensel
wiley   +1 more source

Novel applications of nanobodies for in vivo bio-imaging of inflamed tissues in inflammatory diseases and cancer

, 2012
Steve Schoonooghe, Damya Laoui, Jo A. Van Ginderachter, Nick Devoogdt, Tony Lahoutte, Patrick De Baetselier, Geert Raes   +6 more
openalex   +1 more source

Unlocking Disease‐Modifying Treatments for TDP‐43‐Mediated Neurodegeneration

BioEssays, Volume 47, Issue 4, April 2025.
Early mechanisms of TDP‐43‐mediated neurodegeneration are the key to unlocking novel precision medicine and biomarkers for amyotrophic lateral sclerosis and frontotemporal dementia. ABSTRACT Neurons degenerate in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), causing progressive and inevitably fatal neurological decline.
Rebecca San Gil, Adam K. Walker
wiley   +1 more source

A Thrombocytopenic Thrombotic Purpura in a Patient With a Metastatic HER2+ Breast Cancer: Description of a Case Report

Clinical Case Reports, Volume 13, Issue 4, April 2025.
ABSTRACT Paraneoplastic (p) TTP is a rare syndrome characterized by an immune‐induced, generalized microangiopathy associated with solid or hematological tumors. This case, reporting a patient with a metastatic HER2+ breast cancer and a pTTP, highlights the rarity of this entity, its difficult and challenging diagnosis, and the complexity of its ...
Raffaele Longo, Benjamin Savenkoff, Romane Ribal, Alexandre Dadoun, Marco Campitiello, Francesca Plastino, Pierre‐Olivier Legros, Nathalie Marcon, Paul Coppo, Julie Egea   +9 more
wiley   +1 more source