Results 211 to 220 of about 19,829 (313)

Pancreatic Cancer: Pathogenesis and Clinical Studies

MedComm, Volume 6, Issue 4, April 2025.
Although the treatment landscape for cancer has evolved rapidly in recent years, progress has stagnated for pancreatic cancer (PC). PC includes multiple types, but pancreatic ductal adenocarcinoma (PDAC) accounts for >90% of cases. This review focuses on the molecular pathogenesis and different treatments for PDAC, hoping to propose future directions ...
Kexun Zhou, Yingping Liu, Chuanyun Tang, Hong Zhu   +3 more
wiley   +1 more source

Expediting Glycospace Exploration: Therapeutic Glycans via Automated Synthesis

Angewandte Chemie, Volume 137, Issue 13, March 24, 2025.
The construction of well‐defined carbohydrates constitutes a nexus in glycoscience, but few conceptual paradigms have shaped the field as much as automated glycan synthesis. This minireview describes the structural diversity and function of glycans generated by automated glycan synthesis platforms over the last five years.
James Suri, Ryan Gilmour
wiley   +2 more sources

Epitope-directed selection of GPCR nanobody ligands with evolvable function. [PDF]

Proc Natl Acad Sci U S A
Skiba MA, Canavan C, Nemeth GR, Liu J, Kanso A, Kruse AC.   +5 more
europepmc   +1 more source

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

, 2013
Tim Guilliams, Farah El-Turk, Alexander K. Buell, Elizabeth O’Day, Francesco A. Aprile, Elin K. Esbjörner, Michele Vendruscolo, Nunilo Cremades, Els Pardon, Lode Wyns, Mark E. Welland, Jan Steyaert, John Christodoulou, Christopher M. Dobson, Erwin De Genst   +14 more
openalex   +1 more source

Affinity‐stability trade‐off mechanism of residue 35 in framework region 2 of VHH antibodies with β‐hairpin CDR3

Protein Science, Volume 34, Issue 4, April 2025.
Abstract Single‐domain VHH antibodies are promising therapeutic and diagnostic tools. The third complementarity‐determining region (CDR3) is usually the most critical region for antigen recognition by VHH antibodies. When CDR3 adopts a short and extended β‐hairpin conformation, framework region 2 (FR2) often interacts directly with the antigen. However,
Koichi Yamamoto, Satoru Nagatoishi, Ryo Matsunaga, Makoto Nakakido, Daisuke Kuroda, Kouhei Tsumoto   +5 more
wiley   +1 more source

The Use of Heterologous Antigens for Biopanning Enables the Selection of Broadly Neutralizing Nanobodies Against SARS-CoV-2. [PDF]

Antibodies (Basel)
Aripov VS, Zaykovskaya AV, Mechetina LV, Najakshin AM, Bondar AA, Arkhipov SG, Mustaev EA, Ilyina MG, Borisevich SS, Ilyichev AA, Nesmeyanova VS, Isaeva AA, Volosnikova EA, Shcherbakov DN, Volkova NV.   +14 more
europepmc   +1 more source

Nanobodies as Versatile Tools to Understand, Diagnose, Visualize and Treat Cancer [PDF]

, 2016
Isabel Van Audenhove, Jan Gettemans
openalex   +1 more source

Data‐driven evaluation of suitable immunogens for improved antibody selection

Protein Science, Volume 34, Issue 4, April 2025.
Abstract Antibodies are indispensable in laboratory and clinical applications due to their high specificity and affinity for protein antigens. However, selecting the right protein fragments as immunogens for antibody production remains challenging. Leveraging the Human Protein Atlas, this study systematically evaluates immunogen properties aiming to ...
Katharina Waury, Hlin Kvartsberg, Henrik Zetterberg, Kaj Blennow, Charlotte E. Teunissen, Sanne Abeln   +5 more
wiley   +1 more source

NanoAbLLaMA: construction of nanobody libraries with protein large language models. [PDF]

Front Chem
Wang X, Chen H, Chen B, Liang L, Mei F, Huang B.   +5 more
europepmc   +1 more source

Comprehensive Assessment of M-Proteins Using Nanobody Enrichment Coupled to MALDI-TOF Mass Spectrometry [PDF]

, 2016
John R. Mills, Mindy Kohlhagen, Surendra Dasari, Patrick M. Vanderboom, Robert A. Kyle, Jerry A. Katzmann, Maria Alice V. Willrich, David R. Barnidge, Angela Dispenzieri, David Murray   +9 more
openalex   +1 more source