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Results 221 to 230 of about 16,593 (260)

A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research

International Journal of Cancer, Volume 158, Issue 2, Page 291-304, 15 January 2026.
Abstract Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored. The lack of epigenetic understanding in cancer evolution is in part due to the limited availability of methods to examine such a heterogeneous ...
Marta Moreno‐Gonzalez, Isabel Sierra, Jop Kind +2 more
wiley +1 more source

Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist [PDF]

Thomas D. Fontaine +21 more
openalex +1 more source

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati +4 more
wiley +1 more source

Single-domain antibodies for brain targeting [PDF]

, 2014
Lalatsa, Katerina, Moreira Leite, Diana
core +1 more source

Long-term live-cell microscopy with labeled nanobodies delivered by laser-induced photoporation