Results 51 to 60 of about 19,829 (313)
Molecules, 2023 Nanobodies (Nbs) are single domain antibody fragments derived from heavy-chain antibodies found in members of the Camelidae family. They have become a relevant class of biomolecules for many different applications because of several important advantages ...
M. A. Contreras +9 more
semanticscholar +1 more source
Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3) [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): As T-cell immunoglobulin and mucin domain 3 (TIM-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition.
Vida Homayouni +5 more
doaj +1 more source
Diversity in kinetics correlated with structure in nano body-stabilized LacY.
PLoS ONE, 2020 The structure of lactose permease, stabilized in a periplasmic open conformation by two Gly to Trp replacements (LacYww) and complexed with a nanobody directed against this conformation, provides the highest resolution structure of the symporter.
Hemant Kumar +7 more
doaj +1 more source
Biotechnology & Biotechnological Equipment, 2021 Nanobodies belong to a new generation of antibodies produced by recombinant engineering and have high perspectives in biopharmaceutical drug formulations.
Mohamed Karam Qassas +3 more
doaj +1 more source
131I-Labeled Anti-HER2 Nanobody for Targeted Radionuclide Therapy of HER2-Positive Breast Cancer
International Journal of Nanomedicine, 2023 Purpose The unique structure of nanobodies is advantageous for the development of radiopharmaceuticals for nuclear medicine. Nanobodies targeted to human epidermal growth factor receptor 2 (HER2) can be used as tools for the imaging and therapy of HER2 ...
Lingzhou Zhao +6 more
semanticscholar +1 more source
FASEB BioAdvances, Volume 4, Issue 12, Page 758-774, December 2022., 2022 Abstract The β2AR is a prototypical G protein‐coupled receptor (GPCR) known to orchestrate different cellular responses by the stimulation of specific signaling pathways. The best‐established signaling pathways for the β2AR are the canonical Gs pathway and the alternative β arrestin 2 (βarr2) pathway.
Emilio Y. Lucero‐Garcia Rojas +4 more
wiley +1 more source
Recombinant expression of nanobodies and nanobody-derived immunoreagents
Protein Expression and Purification, 2020 Antibody fragments for which the sequence is available are suitable for straightforward engineering and expression in both eukaryotic and prokaryotic systems. When produced as fusions with convenient tags, they become reagents which pair their selective binding capacity to an orthogonal function.
openaire +4 more sources
Sequence-Based Nanobody-Antigen Binding Prediction [PDF]
arXiv, 2023 Nanobodies (Nb) are monomeric heavy-chain fragments derived from heavy-chain only antibodies naturally found in Camelids and Sharks. Their considerably small size (~3-4 nm; 13 kDa) and favorable biophysical properties make them attractive targets for recombinant production.
arxiv
Scientific Reports, 2021 A fusion protein comprising an antibody and a cationic peptide, such as arginine-9 (R9), is a candidate molecule for efficient and cell-specific delivery of siRNA into cells in order to reduce the side effects of nucleic acid drugs.
Yu Ando +4 more
doaj +1 more source
A novel framework to quantify uncertainty in peptide-tandem mass spectrum matches with application to nanobody peptide identification [PDF]
arXiv, 2021 Nanobodies are small antibody fragments derived from camelids that selectively bind to antigens. These proteins have marked physicochemical properties that support advanced therapeutics, including treatments for SARS-CoV-2. To realize their potential, bottom-up proteomics via liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been proposed ...
arxiv