Results 51 to 60 of about 138,057 (371)

Discovering multiple types of DNA methylation from bacteria and microbiome using nanopore sequencing

Nature Methods, 2021
Bacterial DNA methylation occurs at diverse sequence contexts and plays important functional roles in cellular defense and gene regulation. Existing methods for detecting DNA modification from nanopore sequencing data do not effectively support de novo ...
Alan Tourancheau, E. Mead, Xue-Song Zhang, Gang Fang   +3 more
semanticscholar   +1 more source

Stable fabrication of a large nanopore by controlled dielectric breakdown in a high-pH solution for the detection of various-sized molecules

Scientific Reports, 2019
For nanopore sensing of various-sized molecules with high sensitivity, the size of the nanopore should be adjusted according to the size of each target molecule.
Itaru Yanagi, Rena Akahori, Ken-ichi Takeda   +2 more
doaj   +1 more source

High-Quality Nuclear Genome and Mitogenome of Bipolaris sorokiniana LK93, a Devastating Pathogen Causing Wheat Root Rot

Molecular Plant-Microbe Interactions, 2023
Bipolaris sorokiniana, one of the most devastating hemibiotrophic fungal pathogens, causes root rot, crown rot, leaf blotching, and black embryos of gramineous crops worldwide, posing a serious threat to global food security.
Wanying Zhang, Qun Yang, Lei Yang, Haiyang Li, Wenqing Zhou, Jiaxing Meng, Yanfeng Hu, Limin Wang, Ruijiao Kang, Honglian Li, Shengli Ding, Guotian Li   +11 more
doaj   +1 more source

Polymer translocation through a nanopore under an applied external field [PDF]

, 2006
We investigate the dynamics of polymer translocation through a nanopore under an externally applied field using the 2D fluctuating bond model with single-segment Monte Carlo moves.
Alberts B., Chang D.-C., Darnell J., de Gennes P. G., Doi M., Guo L., Ilkka Huopaniemi, Kaifu Luo, See-Chen Ying, Tapio Ala-Nissila   +9 more
core   +2 more sources

Nanopore native RNA sequencing of a human poly(A) transcriptome

bioRxiv, 2018
High-throughput complementary DNA sequencing technologies have advanced our understanding of transcriptome complexity and regulation. However, these methods lose information contained in biological RNA because the copied reads are often short and ...
R. Workman, Alison D. Tang, Paul S. Tang, Miten Jain, J. R. Tyson, P. Zuzarte, Timothy Gilpatrick, Roham Razaghi, J. Quick, Norah Sadowski, N. Holmes, Jaqueline Goes de Jesus, K. Jones, T. Snutch, N. Loman, Benedict Paten, M. Loose, J. Simpson, Hugh E. Olsen, Angela N. Brooks, M. Akeson, W. Timp   +21 more
semanticscholar   +1 more source

Noise Reduction Method of Nanopore Based on Wavelet and Kalman Filter

Applied Sciences, 2022
Nanopore detection technology has now developed into an indispensable tool for single molecule experiments, in which useful information on molecular properties can be obtained from the ion current flow induced by individual molecules, but the relatively ...
Zhouchang Huang, Xiaoqing Zeng, Deqiang Wang, Shaoxi Fang   +3 more
doaj   +1 more source

Nanopore Sequencing Technology and Tools for Genome Assembly: Computational Analysis of the Current State, Bottlenecks and Future Directions

, 2018
Nanopore sequencing technology has the potential to render other sequencing technologies obsolete with its ability to generate long reads and provide portability.
Alkan, Can, Cali, Damla Senol, Ghose, Saugata, Kim, Jeremie S., Mutlu, Onur   +4 more
core   +2 more sources

Vapor nucleation paths in lyophobic nanopores [PDF]

, 2018
.: In recent years, technologies revolving around the use of lyophobic nanopores gained considerable attention in both fundamental and applied research. Owing to the enormous internal surface area, heterogeneous lyophobic systems (HLS), constituted by a ...
Casciola, Carlo Massimo, Giacomello, Alberto, Tinti, Antonio   +2 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancer

Nature Communications
Telomeres are the protective nucleoprotein structures at the end of linear eukaryotic chromosomes. Telomeres’ repetitive nature and length have traditionally challenged the precise assessment of the composition and length of individual human telomeres ...
Tobias T. Schmidt, Carly Tyer, Preeyesh Rughani, Candy Haggblom, Jeffrey R. Jones, Xiaoguang Dai, Kelly A. Frazer, Fred H. Gage, Sissel Juul, Scott Hickey, Jan Karlseder   +10 more
doaj   +1 more source