Constitutive depletion of Slc34a2/NaPi-IIb in rats causes perinatal mortality [PDF]
Scientific Reports, 2021 Absorption of dietary phosphate (Pi) across intestinal epithelia is a regulated process mediated by transcellular and paracellular pathways. Although hyperphosphatemia is a risk factor for the development of cardiovascular disease, the amount of ingested
Eva Maria Pastor-Arroyo +6 more
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The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction [PDF]
Scientific Reports, 2017 NaPi-IIb/Slc34a2 is a Na+-dependent phosphate transporter that accounts for the majority of active phosphate transport into intestinal epithelial cells.
Giovanni Pellegrini +2 more
exaly +11 more sources
High phosphorus diet-induced changes in NaPi-IIb phosphate transporter expression in the rat kidney: DNA microarray analysis. [PDF]
PLoS ONE, 2012 The mechanism by which phosphorus levels are maintained in the body was investigated by analyzing changes in gene expression in the rat kidney following administration of a high phosphorus (HP) diet.
Tatsuya Suyama +5 more
doaj +7 more sources
Effects of dietary phosphorus and myo-inositol supplementation on NaPi-IIb and TRPV6 protein expression in duodenal apical membranes of laying hens from two strains [PDF]
Poultry SciencePhosphorus (P) and calcium (Ca) absorption in the intestine is mediated by apical brush border membrane (BBM) transporters, including the sodium-dependent phosphate (Pi) transporter NaPi-IIb and the Ca²⁺-selective channel TRPV6. Both are highly expressed
Nataliia Shomina +5 more
doaj +8 more sources
The Influence of Dietary Calcium and Phosphorus Imbalance on Intestinal NaPi-IIb and Calbindin mRNA Expression and Tibia Parameters of Broilers [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 A 2×2 factorial experiment was conducted to study the effect of dietary calcium and non-phytate phosphorus (nPP) imbalance on calbindin and NaPi-IIb mRNA levels in the small intestine and tibia parameters of broiler chicks. One hundred and forty four 1-d-
Jianhui Li +4 more
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NaPi-IIb Inhibition for Hyperphosphatemia in CKD Hemodialysis Patients [PDF]
Kidney International Reports, 2021 Introduction Chronic kidney disease (CKD) has a prevalence of 9.1% globally, and frequently results in elevated serum phosphate, increasing cardiovascular morbidity and mortality risk in hemodialysis (HD) patients.
Maruyama S +5 more
exaly +6 more sources
Vitamin D receptor silencing impairs the 1,25-dihydroxyvitamin D [PDF]
Poultry ScienceOur previous study detected the potential regulatory role of vitamin D receptor (VDR) in 1,25-dihydroxyvitamin D 3 (1,25-(OH) 2 D 3 )-stimulated phosphorus (P) absorption and the type IIb sodium-phosphate cotransporter (NaPi-IIb) gene expression in the ...
Weiyun Zhang +10 more
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Phosphate reabsorption in the kidney: NaPi-IIb or not IIb. [PDF]
Pflugers Arch, 2020 Phosphate is an essential component of nucleic acids, cell membranes and bones, and is important for enzymatic interactions, synthesis of ATP and other signalling and metabolic pathways. The level of inorganic phosphate (Pi) in serum is tightly regulated
Burns D, Werner A.
europepmc +7 more sources
Targeting NaPi-IIb for Hyperphosphatemia in Chronic Kidney Disease Patients - The Dead End? [PDF]
Kidney Int Rep, 2021 Phosphate serves as a structural component of nucleic acids, cell membranes and bones, and is important for enzymatic interactions, ATP synthesis and plays a critical role in cellular signalling through phosphorylation reactions.
Apetrii M, Covic A.
europepmc +5 more sources
The effect of dietary vitamin D supplementation on sodium-dependent phosphate uptake and expression of NaPi-IIb in the small intestine of weanling pigs. [PDF]
J Anim Sci, 2021 Two experiments were conducted to investigate the effects of 1,25(OH)2D3 to stimulate Na+-dependent phosphate uptake in Caco-2 cells, and the effects of dietary vitamin D supplementation to vitamin D-deficient nursery pigs on Na+-dependent nutrient ...
Saddoris KL, Fleet JC, Radcliffe JS.
europepmc +5 more sources