Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb (SLC34A2) by the Kinases SPAK and OSR1
Kidney & Blood Pressure Research, 2015 Background/Aims: SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1), kinases controlled by WNK (with-no-K[Lys] kinase), are powerful regulators of cellular ion transport and blood pressure.
Myriam Fezai +5 more
doaj +6 more sources
Expression of NaPi-IIb in rodent and human kidney and upregulation in a model of chronic kidney disease [PDF]
Pflugers Archiv European Journal of Physiology, 2020 Na$^{+}$-coupled phosphate cotransporters from the SLC34 and SLC20 families of solute carriers mediate transepithelial transport of inorganic phosphate (Pi). NaPi-IIa/Slc34a1, NaPi-IIc/Slc34a3, and Pit-2/Slc20a2 are all expressed at the apical membrane of renal proximal tubules and therefore contribute to renal Pi reabsorption. Unlike NaPi-IIa and NaPi-
Nati Hernando +2 more
exaly +8 more sources
Intestinal Depletion of NaPi-IIb/Slc34a2 in Mice: Renal and Hormonal Adaptation [PDF]
Journal of Bone and Mineral Research, 2015 Abstract The Na+-dependent phosphate-cotransporter NaPi-IIb (SLC34A2) is widely expressed, with intestine, lung, and testis among the organs with highest levels of mRNA abundance. In mice, the intestinal expression of NaPi-IIb is restricted to the ileum, where the cotransporter localizes ...
Nati Hernando +2 more
exaly +6 more sources
Clinical aspects of the phosphate transporters NaPi-IIa and NaPi-IIb: mutations and disease associations [PDF]
Pflugers Archiv European Journal of Physiology, 2018 The Na-dependent phosphate transporter NaPi-IIa (SLC34A1) is mostly expressed in kidney, whereas NaPi-IIb (SLC34A2) has a wider tissue distribution with prominent expression in the lung and small intestine. NaPi-IIa is involved in renal reabsorption of inorganic phosphate (Pi) from urine, and patients with biallelic inactivating mutations in SLC34A1 ...
Carsten A. Wagner
exaly +7 more sources
Development of a label-free assay for sodium-dependent phosphate transporter NaPi-IIb. [PDF]
Journal of Biomolecular Screening, 2012 The most widely used assay format for characterizing plasma membrane transporter activity measures accumulation of radiolabeled substrates in tissues or cells expressing the transporters.
Soo-Hang Wong +4 more
exaly +4 more sources
Cation Interactions and Membrane Potential Induce Conformational Changes in NaPi-IIb. [PDF]
Biophys J, 2016 Voltage-dependence of Na(+)-coupled phosphate cotransporters of the SLC34 family arises from displacement of charges intrinsic to the protein and the binding/release of one Na(+) ion in response to changes in the transmembrane electric field. Candidate coordination residues for the cation at the Na1 site were previously predicted by structural modeling
Patti M +4 more
europepmc +7 more sources
Dexamethasone and Cyclic AMP Regulate Sodium Phosphate Cotransporter (NaPi-IIb and Pit-1) mRNA and Phosphate Uptake in Rat Alveolar Type II Epithelial Cells [PDF]
Lung, 2009 Alveolar epithelial type II (AT II) cells need phosphate (Pi) for surfactant synthesis. The Na-dependent (Na(d)) Pi transporters NaPi-IIb and Pit-1 are expressed in lung, but their expression, regulation, and function in AT II cells remain unclear. We studied NaPi-IIb and Pit-1 mRNA expression in cultured AT II cells isolated from adult rat lung, their
Evangelos Zoidis, Christoph Schmid
exaly +7 more sources
Exploration of Some Nutrient Absorption–Related Genes and Intestinal Histology in Japanese Quails (Coturnix japonica) Throughout Their Productive Lifespan [PDF]
Veterinary Medicine and ScienceBackground Quail is an efficient poultry species known for many years, and its productivity is highly affected by gastrointestinal function, health, digestion and commensal bacteria.
Hamid Reza Rafieian‐Naeini +6 more
doaj +3 more sources
PKA and PKC signaling pathways mediate vitamin D₃-regulated intestinal phosphorus absorption in broiler chickens [PDF]
Poultry ScienceThree experiments were conducted to investigate the functional roles of the protein kinase A (PKA) and protein kinase C (PKC) signaling pathways in vitamin D₃ (VD₃)-regulated intestinal phosphorus (P) absorption in broiler chickens. Experiment 1 examined
Mengyuan Liu +11 more
doaj +2 more sources
Nephrology Dialysis Transplantation, 2023 Renal reabsorption of phosphate is mediated by 3 main transporters located in the luminal brush border membrane of the proximal tubule, namely NaPi-IIa (SLC34A1), NaPi-IIc (SLC34A3), and Pit2 (SLC20A2). The expression of all three proteins has been
Rupert W Busch +6 more
semanticscholar +2 more sources