Results 61 to 70 of about 20,829 (242)

Measurement of narcolepsy symptoms: the narcolepsy severity scale [PDF]

Sleep Medicine, 2017
To validate the Narcolepsy Severity Scale (NSS), a brief clinical instrument to evaluate the severity and consequences of symptoms in patients with narcolepsy type 1 (NT1).A 15-item scale to assess the frequency and severity of excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, sleep paralysis, and disrupted nighttime sleep was ...
Dauvilliers, Yves, Beziat, Isabelle, Pesenti, Carole, Lopez, Régis, Barateau, Lucie, Carlander, Bertrand, Lucas, G, Tafti, M, Morin, Charles, Billiard, Michel, Jaussent, Isabelle   +10 more
openaire   +3 more sources

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

A Case of Secondary Narcolepsy Presenting with Obstructive Sleep Apnea Symptoms

Türk Uyku Tıbbı Dergisi, 2016
Obstructive sleep apnea syndrome (OSAS) and narcolepsy are two diseases causing excessive daytime sleepiness (EDS). As they are often confused, these two disorders can also coexist.
Sebahat Genç, Hatice Kayim Bilgiç, Emine Esra Okuyucu, Nursel Dikmen, Taskin Duman   +4 more
doaj   +1 more source

Ageing‐related modification of sleep and breathing in orexin‐knockout narcoleptic mice

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Narcolepsy type‐1 (NT1) is a lifelong sleep disease, characterised by impairment of the orexinergic system, with a typical onset during adolescence and young adulthood. Since the wake–sleep cycle physiologically changes with ageing, this study aims to compare sleep patterns between orexin‐knockout (KO) and wild type (WT) control mice at ...
Stefano Bastianini, Sara Alvente, Chiara Berteotti, Viviana Lo Martire, Gabriele Matteoli, Elena Miglioranza, Alessandro Silvani, Giovanna Zoccoli   +7 more
wiley   +1 more source

The Impact of Sleep Pattern in School/Work Performance During the COVID-19 Home Quarantine in Patients With Narcolepsy [PDF]

, 2022
Mengke Zhao, Baokun Zhang, Jiyou Tang, Xiao Zhang   +3 more
openalex   +1 more source

Profiling the sleep architecture of ageing adults using a seven‐state continuous‐time Markov model

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleep is a complex biological process regulated by networks of neurons and environmental factors. As one falls asleep, neurotransmitters from sleep–wake regulating neurones work in synergy to control the switching of different sleep states throughout the night. As sleep disorders or underlying neuropathology can manifest as irregular switching,
Jonathon Jacobs, Caitlin E. Martin, Bernard Fuemmeler, Shanshan Chen   +3 more
wiley   +1 more source

Decrease of excessive daytime sleepiness after shunt treatment for normal pressure hydrocephalus

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleepiness and apathy are often reported in patients with normal pressure hydrocephalus. However, research on outcomes after shunt surgery has mainly focused on the classical triad symptoms, that is, gait, cognition, and bladder dysfunction. This study aimed to describe the effects of shunt treatment on excessive daytime sleepiness and whether ...
Simon Lidén, Anna Lindam, Dan Farahmand, Anne‐Marie Landtblom, Katarina Laurell   +4 more
wiley   +1 more source

Respiratory safety of lemborexant in adult and elderly subjects with moderate‐to‐severe chronic obstructive pulmonary disease

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Lemborexant 10 mg, a dual orexin‐receptor antagonist (DORA), did not elicit respiratory depressant effects, as measured by peripheral oxygen saturation (SpO2) or apnea–hypopnea index (AHI), in subjects with moderate‐to‐severe chronic obstructive pulmonary disease (COPD).
Jocelyn Y. Cheng, Daniel Lorch, Nancy Hall, Margaret Moline   +3 more
wiley   +1 more source

Relationship between T-cell receptor α gene polymorphisms and symptomatic differences in patients with narcolepsy type 1

Chinese Medical Journal, 2019
. Background:. Recent genome-wide association studies have identified an important role of T-cell receptor α (TRA) gene in the development of narcolepsy type 1.
Hui Ouyang, Fang Han, Ze-Chen Zhou, Qi-Wen Zheng, Yang-Yang Wang, Jun Zhang, Qiang Shi   +6 more
doaj   +1 more source

The Effects of Daridorexant on Patients With Comorbid Insomnia Disorder and Untreated Mild Obstructive Sleep Apnoea: A Post Hoc Subgroup Analysis of a Phase 3, Randomised Clinical Trial

Journal of Sleep Research, EarlyView.
ABSTRACT Daridorexant, a dual orexin receptor antagonist, is approved for the treatment of insomnia disorder in adults. Approximately 30%–35% of patients with insomnia disorder also have obstructive sleep apnoea (OSA) of any severity. It is unclear whether sleep medications provide safe and effective treatment for insomnia in these patients.
Christopher J. Lettieri, Orestis Briasoulis, Damien Léger, Pierre‐Philippe Luyet, Jean‐Louis Pépin, Stuart F. Quan, Janna Raphelson, Paul Saskin, Atul Malhotra   +8 more
wiley   +1 more source