Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]
, 1995 Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core +1 more source
Effects of selective opiate antagonists on morphine-induced hyperalgesia in domestic fowl [PDF]
, 1990 Morphine typically produces analgesia in a variety of species by acting as an agonist at mu and perhaps delta opioid receptors. Recent research, however, has identified a biological model in which morphine produces a naloxone-reversible, paradoxical ...
Sufka, Kenneth Joseph
core +2 more sources
Trends in resource utilization for new‐onset psychosis hospitalizations at children's hospitals
Journal of Hospital Medicine, EarlyView.Abstract Background Children with new‐onset psychosis often require hospitalization for medical evaluation. Objectives The goal of this study was to assess variations in the management of children with new‐onset psychosis and characterize trends in resource utilization.
Ankita Gupta +8 more
wiley +1 more source
Identification of a Novel “Almost Neutral” Mu Opioid Receptor Antagonist in CHO Cells Expressing the Cloned Human Mu Opioid Receptor [PDF]
, 2010 The basal (constitutive) activity of G protein-coupled receptors allows for the measurement of inverse agonist activity. Some competitive antagonists turn into inverse agonists under conditions where receptors are constitutively active.
Bilsky, Edward J. +12 more
core +1 more source
Cyclical medication management interventions in health care settings: A systematic review
Learning Health Systems, EarlyView.Abstract Introduction It is estimated that one in 30 patients experiences at least one preventable medication‐related harm while receiving care. Cyclical medicine improvement interventions, where health systems continuously collect data, implement prescribing/dispensing interventions, review outcomes, and revise the intervention, have demonstrated ...
Isabelle Meulenbroeks +6 more
wiley +1 more source
Towards Better Opioid Antagonists Using Deep Reinforcement Learning [PDF]
arXiv, 2020 Naloxone, an opioid antagonist, has been widely used to save lives from opioid overdose, a leading cause for death in the opioid epidemic. However, naloxone has short brain retention ability, which limits its therapeutic efficacy. Developing better opioid antagonists is critical in combating the opioid epidemic.Instead of exhaustively searching in a ...
arxiv
Amniotic-Fluid Ingestion Enhances\ud Morphine Analgesia During Morphine\ud Tolerance and Withdrawal in Rats [PDF]
, 1991 Ingestion of placenta and amniotic fluid has been shown to enhance opioid-mediated analgesia in rats produced by morphine injection. footshock, vaginal/cervical stimulation, and during late pregnancy.
Doerr, Jean C., Kristal, Dr. Mark B.
core
Orphan crops of archaeology‐based crop history research
PLANTS, PEOPLE, PLANET, EarlyView.Agrobiodiversity is central to sustainable farming worldwide. Cultivation, conservation and reintroduction of diverse plant species, including ‘forgotten’ and ‘underutilized’ crops, contribute to global agrobiodiversity, living ecosystems and sustainable food production.
Daniel Fuks +23 more
wiley +1 more source
The analgesic effects of anti-inflammatory drugs from the point of view of different pharmacological test methods [PDF]
, 1964 1. The forms of irritation causing inflammation and pain are reviewed, with reference to the significance of histamine, serotonin and bradykinin and in particular to the interrelationship between inflammation and pain. 2.
Wilhelmi, G.
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Sustainable Development, EarlyView.ABSTRACT Operationalizing the indivisibility and integrated nature of the UN 2030 Agenda poses a complex governance challenge. Although research has advanced our understanding of SDG localization and interlinkages, important gaps remain. In this paper, we depart from these two strands of literature by asking how synergies and trade‐offs manifest in ...
Sara Gottenhuber +3 more
wiley +1 more source