Genetically Engineered Phages: a Review of Advances over the Last Decade [PDF]
, 2016 Summary: Soon after their discovery in the early 20th century, bacteriophages were recognized to have great potential as antimicrobial agents, a potential that has yet to be fully realized.
Alberts B +17 more
core +1 more source
Thermophile Lytic Enzyme Fusion Proteins that Target Clostridium perfringens
Antibiotics, 2019 Clostridium perfringens is a bacterial pathogen that causes necrotic enteritis in poultry and livestock, and is a source of food poisoning and gas gangrene in humans.
Steven M. Swift +3 more
doaj +1 more source
Improving recombinant protein production in the Chlamydomonas reinhardtii chloroplast using vivid Verde Fluorescent Protein as a reporter [PDF]
, 2015 Microalgae have potential as platforms for the synthesis of high-value recombinant proteins due to their many beneficial attributes including ease of cultivation, lack of pathogenic agents, and low-cost downstream processing. However, current recombinant
Baganz, F, Braun-Galleani, S, Purton, S
core +1 more source
A thermostable salmonella phage endolysin, Lys68, with broad bactericidal properties against gram-negative pathogens in presence of weak acids [PDF]
, 2014 Resistance rates are increasing among several problematic Gram-negative pathogens, a fact that has encouraged the development of new antimicrobial agents.
A Wohlkonig +38 more
core +3 more sources
Genetically modified bacteriophages [PDF]
, 2016 Phages or bacteriophages, viruses that infect and replicate inside bacteria, are the most abundant microorganisms on earth. The realization that antibiotic resistance poses a substantial risk to the world’s health and global economy is revitalizing phage
Grigonyte, Aurelija M. +3 more
core +1 more source
Design strategies for positively charged endolysins: Insights into Artilysin development [PDF]
, 2023 Endolysins are bacteriophage-encoded enzymes that can specifically degrade the peptidoglycan layer of bacterial cell wall, making them an attractive tool for the development of novel antibacterial agents. The use of genetic engineering techniques for the
Arís, Anna +3 more
core +4 more sources
Bacteriophage endolysins as a response to emerging foodborne pathogens [PDF]
, 2012 Continuous reports on foodborne outbreaks and increasing prevalence of antibiotic-resistant bacteria call for the development of novel preservation techniques that assure the safety of food products.
Azeredo, Joana +3 more
core +1 more source
Synthesis of bacteriophage lytic proteins against Streptococcus pneumoniae in the chloroplast of Chlamydomonas reinhardtii. [PDF]
, 2017 There is a pressing need to develop novel antibacterial agents given the widespread antibiotic resistance among pathogenic bacteria and the low specificity of the drugs available.
Charalambous, B +3 more
core +1 more source
MmpL3 is the flippase for mycolic acids in mycobacteria [PDF]
, 2017 The defining feature of the mycobacterial outer membrane (OM) is the presence of mycolic acids (MAs), which, in part, render the bilayer extremely hydrophobic and impermeable to external insults, including many antibiotics.
Chng, Shu-Sin +3 more
core +1 more source
Phage-Encoded Cationic Antimicrobial Peptide Required for Lysis [PDF]
, 2022 : Most phages of Gram-negative bacteria hosts encode spanins for disruption of the outer membrane, which is the last step in host lysis. However, bioinformatic analysis indicates that ∼15% of these phages lack a spanin gene, suggesting they have an ...
Cahill, Jesse +11 more
core +2 more sources