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Therapeutic Applications: Natural Killer Cells [PDF]
Journal of Clinical and Diagnostic Research, 2018 Natural Killer (NK) cells are potent cytotoxic effector cells for cancer therapy and also for keeping severe viral infections in check. Since, they represent only 10% of the lymphocytes and are often dysfunctional, there are technical challenges in ...
Preeti Sharma +2 more
doaj +1 more source
Natural killer cell deficiency [PDF]
Journal of Allergy and Clinical Immunology, 2013 Natural killer (NK) cells are part of the innate immune defense against infection and cancer and are especially useful in combating certain viral pathogens. The utility of NK cells in human health has been underscored by a growing number of persons who are deficient in NK cells and/or their functions. This can be in the context of a broader genetically
openaire +2 more sources
Deciphering Natural Killer Cell Homeostasis [PDF]
Frontiers in Immunology, 2020 Natural killer (NK) cells have a central role within the innate immune system, eliminating virally infected, foreign and transformed cells through their natural cytotoxic capacity. Release of their cytotoxic granules is tightly controlled through the balance of a large repertoire of inhibitory and activating receptors, and it is the unique combination ...
Aline Pfefferle +9 more
openaire +5 more sources
Regulation of NKG2D-Dependent NK Cell Functions: The Yin and the Yang of Receptor Endocytosis. [PDF]
, 2017 Natural-killer receptor group 2, member D (NKG2D) is a well characterized natural killer (NK) cell activating receptor that recognizes several ligands poorly expressed on healthy cells but up-regulated upon stressing stimuli in the context of cancer or ...
Molfetta, R +3 more
core +2 more sources
MicroRNA regulation of natural killer cells [PDF]
, 2013 Natural killer (NK) cells are innate immune lymphocytes critical for host defense against viral infection and surveillance against malignant transformation.
Fehniger, Todd A +2 more
core +5 more sources
Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage. [PDF]
PLoS ONE, 2015 The analysis of gene function in mature and activated natural killer cells has been hampered by the lack of model systems for Cre-mediated recombination in these cells.
Yiying Xu +4 more
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Altered distribution of mucosal NK cells during HIV infection. [PDF]
, 2012 The human gut mucosa is a major site of human immunodeficiency virus (HIV) infection and infection-associated pathogenesis. Increasing evidence shows that natural killer (NK) cells have an important role in control of HIV infection, but the mechanism(s ...
Alter, G +13 more
core +2 more sources
Natural Killer Cells: Development, Maturation, and Clinical Utilization
Frontiers in Immunology, 2018 Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-tumor and anti-viral responses, and therefore possess promising clinical utilization.
Alex M. Abel +3 more
semanticscholar +1 more source
Measurement of uterine natural killer cell percentage in the periimplantation endometrium from fertile women and women with recurrent reproductive failure: establishment of a reference range [PDF]
, 2017 Background Uterine natural killer cells are the major leukocytes present in the periimplantation endometrium. Previous studies have found controversial differences in uterine natural killer cell percentage in women with recurrent reproductive ...
Chen, Xiaoyan +6 more
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PLoS ONE, 2019 Glioblastoma is the leading malignant glioma with a poor prognosis. This study aimed to investigate the antitumor effects of natural killer cells in combination with temozolomide as the standard chemotherapeutic agent for glioblastoma.
Yoshitaka Tanaka +12 more
doaj +1 more source