Results 231 to 240 of about 226,818 (311)

SMAD7 drives natural killer cell antitumor activity through canonical TGF-β blockade and non-canonical transcriptional activation of STAT5A. [PDF]

J Immunother Cancer
Li J, Liu T, Xiao W, Zhao D, Li Q, Liu S, Li X, Tong Y, Li H, Jiang H, Wu S, Li Z, Tu H, Gan Y.   +13 more
europepmc   +1 more source

Expression and Functional Role of α7 Nicotinic Receptor in Human Cytokine-stimulated Natural Killer (NK) Cells. [PDF]

J Biol Chem, 2016
Zanetti SR, Ziblat A, Torres NI, Zwirner NW, Bouzat C.   +4 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Napabucasin transforms liver microenvironment and boosts immunotherapy efficacy by converting potential metastases into “hot” tumors

Interdisciplinary Medicine, EarlyView.
Napabucasin reduces liver metastases by reprogramming the hepatic microenvironment. It induces hepatocyte secretion of CCL21 via c‐Fos activation, recruiting lymphocytes and converting “cold” metastases into immunologically “hot” tumors. This effect is liver‐specific and independent of cancer cells.
Qiongqiong Wang, Jiaqi Zhou, Hang Qiao, Yifan Jia, Ling Ye, Zeli Li, Jiahe Ouyang, Haoxian Zhou, Kangxin Zeng, Xuemeng Wang, Yixian Wang, Yang Zhang, Yupeng Zhang, Yizhou Cai, Yutao Hu, Minzhe Zhang, Wenwei Xu, Zhenzhen Wu, Xiaofang Qiu, Li Lin   +19 more
wiley   +1 more source

Major histocompatibility complex class I chain-related A and B molecules and their potential role in virus-associated cancers. [PDF]

World J Virol
Bouayad A.
europepmc   +1 more source

Monocytes with trained immunity–like signatures are associated with acute anterior uveitis in ankylosing spondylitis

Interdisciplinary Medicine, EarlyView.
In ankylosing spondylitis‐acute anterior uveitis (AS‐AAU), trained immunity monocytes (Mono‐TI) differentiate into macrophages in the eye, retaining trained immunity features. Mono‐TI cells secrete pro‐inflammatory cytokines and chemokines, including IL‐1β, TNF‐α, and CCL3.
Yimeng Sun, Lu Zhang, Xinyu Yao, Yunfei Liu, Xin Li, Feng Wen, Yong Dai, Ye Dai, Ziyu Du, Dijie Qiao, Ziwei Meng, Cong Hu, Chun Yan, Wei Chi   +13 more
wiley   +1 more source

Effective allogeneic natural killer cell therapy for pancreatic adenocarcinoma avails conserved activating receptors and evades HLA I-driven inhibition. [PDF]

J Immunother Cancer
Lee SN, Arseneau RJ, Arnason T, Boudreau JE.   +3 more
europepmc   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

An Immunomodulating Peptide With Potential to Counteract Endometriosis. [PDF]

Aust N Z J Obstet Gynaecol
Agrez M.
europepmc   +1 more source

Analysis of the Recovery of Immune Status in the Patients With Paroxysmal Nocturnal Hemoglobinuria After Treatment With C5 Complement Inhibitor

Journal of Clinical Laboratory Analysis, EarlyView.
We retrospectively evaluated the impact of C5 complement inhibition on immune cell profiles and recovery in 27 PNH patients; both CD4+ and CD8+ T cells exhibited partial recovery, while B cell counts increased but remained below normal levels. In contrast, Treg cells were significantly reduced in PNH patients and showed no notable change post‐treatment.
Hui Liu, Mengting Che, Liyan Li, Honglei Wang, Chaomeng Wang, Junshu Wu, Yingying Chen, Zhaoyun Liu, Lijuan Li, Rong Fu   +9 more
wiley   +1 more source