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Granzyme B and natural killer (NK) cell death
Modern Rheumatology, 2005Granzyme B is a unique serine protease, which plays a crucial role for target cell death. Several mechanisms of delivery of granzyme B to target cells have been recently identified. Granzyme B directly activates Bid, a specific substrate for granzyme B, resulting in caspase activation. Granzyme B efficiently cleaves many prominent autoantigens, and the
Hiroaki, Ida +3 more
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American Journal of Reproductive Immunology, 2007
Natural killer (NK) cells are a key component of innate immunity, particularly crucial during the early phase of immune responses against certain viruses, parasites, and microbial pathogens. The role of NK cell during pregnancy has been vividly discussed over the past years and it is now becoming increasingly clear that NK cells control pregnancy ...
SANTONI, Angela +3 more
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Natural killer (NK) cells are a key component of innate immunity, particularly crucial during the early phase of immune responses against certain viruses, parasites, and microbial pathogens. The role of NK cell during pregnancy has been vividly discussed over the past years and it is now becoming increasingly clear that NK cells control pregnancy ...
SANTONI, Angela +3 more
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Natural killer (NK) cells prevent virus production in cell culture
Bone Marrow Transplantation, 1999Natural killer (NK) cells (CD3-/CD16+/CD56+ lymphocytes) play an important role in early immune defense against viral infection, a fact which is of prime significance for heavily immunosuppressed patients after bone marrow transplantation. In this study we demonstrate that NK cells preferentially lyse human colon adenocarcinoma (Colo-205) tumor cells ...
L, Baraz +4 more
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Cell surface markers of the canine natural killer (NK) cell
Veterinary Immunology and Immunopathology, 1985Studies were performed to determine which of several cell surface markers are expressed on canine peripheral blood leukocyte (PBL) natural killer (NK) cells. Chromium-51 release assays showed a decrease in NK activity after depletion of PBL by carbonyl iron ingestion and adherence to IgG-antibody-coated ovine erythrocytes (EA gamma) and to IgM-antibody-
S S, Ringler, S, Krakowka
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Isolation and characterization of porcine natural killer (NK) cells
Veterinary Immunology and Immunopathology, 1987The morphologic and biological properties of porcine cells mediating natural killer (NK) activity were determined. In a previous study, we demonstrated that lymphocytes from the peripheral blood of pigs greater than 1 week of age possessed NK activity to K562 tumor cells and that lymphocytes from the blood and spleen of pigs greater than 1 day of age ...
W C, Yang, R D, Schultz, J S, Spano
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Measurements of Natural Killer (NK) Activity and NK-Cell Quantification
Methods, 1996Natural killer (NK) cells are a subset of lymphocytes with a distinct morphology and the ability to kill certain target cells via one or more cytolytic mechanisms. Measurements of in vitro NK activity from heparinized whole blood, or lymphocytes isolated from human peripheral blood or tissue, may be performed by a variety of techniques.
, Friberg, , Bryant, , Whiteside
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Studies on natural killer (NK) cells IV NK‐3·1: A new NK cell specific alloantigen
Immunology & Cell Biology, 1989SummaryA new murine natural killer (NK) cell alloantigen, NK‐3·1, has been identified by analysis of the complement dependent anti‐NK cell activity of C3H anti‐ST and BALB/c anti‐DBA/2 alloantisera. Flow cytometric studies with a specific antiserum made in backcross mice indicate that this alloantigen is expressed by 2‐3% of the spleen cells of NZB and
R C, Burton +3 more
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Natural killer (NK) cell and immunotherapy.
Nihon rinsho. Japanese journal of clinical medicine, 2019Natural killer (NK) cells are innate lymphoid cells important for host defense against patho- gens, and are also thought to play an important role in the immunosurveillance against can- cers. NK cells express surface receptors that interact with target cells and determine their response to infected or transformed cells without prior sensitization or ...
Tadafumi, Iino, Shigeo, Takaishi
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Evaluation of Natural Killer (NK) Cell Defects
2016Genetic defects in natural killer (NK) cell and cytotoxic T lymphocyte (CTL) function generally lead to one of two outcomes: (i) life-threatening and/or severe chronic infections with viruses, particularly from the Herpesviridae family member viruses Epstein-Barr virus, cytomegalovirus, herpes simplex viruses, and varicella-zoster virus but also other ...
Kimberly Risma, Rebecca Marsh
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ONTOGENY OF Nk-1+ NATURAL KILLER CELLS
1982Publisher Summary Recent experiments have demonstrated Nk-1 antigen to be specific for murine NK cells capable of lysing lymphoma targets. The protein A-SRBC rosette assay was used in a study described in the chapter to monitor the proportion of Nk-1+ cells in tissues of mice and induction assays were performed with interferon to look for precursors ...
G.C. Koo +3 more
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