Results 31 to 40 of about 12,894,217 (402)
Natural products genomics [PDF]
Microbial Biotechnology, 2008 Secondary metabolites (or natural products) are often synthesized by multi‐modular, multi‐domain proteins called non‐ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS). Various well‐known metabolites produced by microorganisms are listed in Table 1, and examples of structures are shown in Fig. 1. In particular, Streptomyces species are
Siezen, R.J., Khayatt, B.
openaire +4 more sources
Antioxidants of Natural Products [PDF]
Antioxidants, 2021 Antioxidant ingredients are known to contribute to the beneficial effects of natural products in health promotion as well as disease prevention by reducing oxidative stress, caused by reactive oxygen or nitrogen species, in biological systems [...]
openaire +3 more sources
BMC Bioinformatics, 2020 Background Despite continued efforts using chemical similarity methods in virtual screening, currently developed approaches suffer from time-consuming multistep procedures and low success rates.
Prasannavenkatesh Durai +3 more
doaj +1 more source
Natural products and drug discovery
National Science Review, 2022 This review covers the recent history of a series of very important natural products and their derivatives that are currently in use or under evaluation in the areas of anti-infectives, important cancer treatments that include antibody drug conjugates ...
D. Newman
semanticscholar +1 more source
Physalin A regulates the Nrf2 pathway through ERK and p38 for induction of detoxifying enzymes
BMC Complementary and Alternative Medicine, 2019 Background Physalin A isolated from Physalis alkekengi var. franchetii has been known to have many pharmacological properties. However, its effect through the Nrf2 pathway has not yet been elucidated.
Ji Min Shin +4 more
doaj +1 more source
Strain prioritization and genome mining for enediyne natural products [PDF]
, 2016 The enediyne family of natural products has had a profound impact on modern chemistry, biology, and medicine, and yet only 11 enediynes have been structurally characterized to date.
Ben Shen +18 more
core +2 more sources
Novel Thioethers of Dihydroartemisinin Exhibiting Their Biological Activities
Heteroatom Chemistry, 2023 Eleven conjugates between dihydroartemisinin (DHA) with thiols containing both ether and thioether bonds were designed, synthesized by a two-step procedure including etherification and S-alkylation.
Ngoc Hung Truong +6 more
doaj +1 more source
BMC Complementary Medicine and Therapies, 2020 Background Circaea mollis Sieb. & Zucc. has been used as a traditional herbal medicine in Hani Ethnopharmacy and possesses anti-arthritic activities.
Ji Hye Park +4 more
doaj +1 more source
Molecules, 2021 Tyrosinase is an enzyme that plays a crucial role in the melanogenesis of humans and the browning of food products. Thus, tyrosinase inhibitors that are useful to the cosmetic and food industries are required.
Prasannavenkatesh Durai +4 more
doaj +1 more source
Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. [PDF]
, 2015 Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of ternatin,
Carelli, Jordan D +8 more
core +2 more sources