Results 1 to 10 of about 17,127 (173)

Morin combined with meropenem is a potent inhibitor of NDM-1 against NDM-1-producing E. coli [PDF]

Scientific Reports
Some β-lactam antibiotics are hydrolyzed by the enzyme New Delhi metallo-β-lactamase 1 (NDM-1), increasing antibiotic resistance and posing a significant threat to public health. Thus, there is an urgent need to develop and use potent inhibitors of NDM-1
Qinghai Ren, Boyang Zhang, Minge Wang, Tongtong Wang, Wei Zhang, Li Du, Meng Yu, Yubao Li, Xiaoting Li   +8 more
doaj   +3 more sources

The directed evolution of NDM-1. [PDF]

Antimicrob Agents Chemother, 2023
ABSTRACT β-Lactam antibiotics are among the most frequently prescribed therapeutic agents. A common mechanism of resistance toward β-lactam antibiotics is the production of β-lactamases. These enzymes are capable of hydrolyzing the β-lactam bond, rendering the drug inactive.
Thomas CA, Cheng Z, Bethel CR, Hujer AM, Sturgill AM, Onuoha K, Page RC, Bonomo RA, Crowder MW.   +8 more
europepmc   +3 more sources

NDM-1 plasmid clustering reflects clonal transmission of Klebsiella pneumoniae ST147 in four hospitals in Berlin, Germany [PDF]

Antimicrobial Resistance and Infection Control
Background In recent years, the detection of Klebsiella pneumoniae (KLPN) producing New Delhi metallo-β-lactamase (NDM), particularly NDM-1, has increased in Germany.
Anna Weber, Luisa Denkel, Christine Geffers, Axel Kola, Friederike Maechler   +4 more
doaj   +2 more sources

The transferability and evolution of NDM-1 and KPC-2 co-producing Klebsiella pneumoniae from clinical settings

EBioMedicine, 2020
Background: Emergence of KPC-2 and NDM-1-coproducing carbapenem-resistant Klebsiella pneumoniae (KPC-2-NDM-1-CRKP) has escalated threat of CRKP to healthcare. Currently, only 4 isolates had been reported sporadically.
Hua Gao, Yudong Liu, Longyang Jin
exaly   +3 more sources

Production of plasmid-encoding NDM-1 in clinical Raoultella ornithinolytica and Leclercia adecarboxylata from China

Frontiers in Microbiology, 2015
Raoultella ornithinolytica YNKP001 and Leclercia adecarboxylata P10164, harboring conjugative plasmids pYNKP001-NDM and pP10164-NDM with determination of complete nucleotide sequences, respectively, were isolated from two different Chinese patients ...
Fengjun Sun, Peiyuan Xia, Dongsheng Zhou
exaly   +3 more sources

In Silico Evaluation of Potential NDM-1 Inhibitors: An Integrated Docking and Molecular Dynamics Approach [PDF]

Pharmaceuticals
Background/Objectives: Non-fermenting Gram-negative bacteria are resistant to most antibiotics, due to the production of enzymes such as NDM-1. Faced with this challenge, computational methods have become essential for the design of NDM-1 carbapenemase ...
Eduvan Valencia, Mauricio Galvis, Jorge Nisperuza, Vladimir Ballesteros, Fredy Mesa   +4 more
doaj   +2 more sources

Cefiderocol-Based Regimen for Acinetobacter NDM-1 Outbreak. [PDF]

Antibiotics (Basel)
Variable outcomes have been reported with cefiderocol in infections due to carbapenem-resistant Acinetobacter baumannii (CRAB). Nonetheless, it may be the only option for metallo-beta-lactamase-producing strains. We describe an outbreak of NDM-CRAB infections treated with cefiderocol. Thirty-eight patients were colonized and/or infected.
Travi G, Peracchi F, Merli M, Lo Re N, Matarazzo E, Tartaglione L, Bielli A, Casalicchio G, Crippa F, Vismara CS, Puoti M.   +10 more
europepmc   +4 more sources

Embelin Restores Carbapenem Efficacy against NDM-1-Positive Pathogens [PDF]

Frontiers in Microbiology, 2018
The emergence and spread of carbapenemase in Gram-negative pathogens poses an enormous threat to global public health. New Delhi metallo-β-lactamase-1 (NDM-1) inactivates nearly every class of β-lactam antibiotics, including carbapenem; however, there is
Nian-Zhi Ning, Xiong Liu, Fanghong Chen, Peng Zhou, Peng Zhou, Lihong Hu, Jian Huang, Jian Huang, Zhan Li, Jie Huang, Tao Li, Hui Wang   +11 more
doaj   +3 more sources

Genetic basis of transmission of bla NDM-1 among foodborne Vibrio parahaemolyticus strains in China [PDF]

Applied Microbiology and Biotechnology
Carbapenem-resistant Vibrio parahaemolyticus has emerged and spread extensively in China, posing a substantial threat to food safety and human health. This study investigated the prevalence of carbapenem resistance in V.
Dan Chen, Ruanyang Sun, Jing Wang, Kaichao Chen, Miaomiao Xie, Qinlu Lin, Jinwang Li, Sheng Chen, Xiaobo Liu   +8 more
doaj   +2 more sources

The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase

Nature Communications, 2019
The NDM-1 metallo-β-lactamase confers resistance to β-lactam antibiotics. Here, the authors show that the antimicrobial peptide thanatin is active against NDM-1-producing bacteria through a dual mechanism of action consisting of disruption of outer ...
Bo Ma, Chao Fang, Xiao-yan Xue
exaly   +2 more sources