Results 1 to 10 of about 107,878,294 (207)

Morin combined with meropenem is a potent inhibitor of NDM-1 against NDM-1-producing E. coli [PDF]

Scientific Reports
Some β-lactam antibiotics are hydrolyzed by the enzyme New Delhi metallo-β-lactamase 1 (NDM-1), increasing antibiotic resistance and posing a significant threat to public health. Thus, there is an urgent need to develop and use potent inhibitors of NDM-1
Qinghai Ren, Boyang Zhang, Minge Wang, Tongtong Wang, Wei Zhang, Li Du, Meng Yu, Yubao Li, Xiaoting Li   +8 more
doaj   +4 more sources

Production of Plasmid-Encoding NDM-1 in Clinical Raoultella ornithinolytica and Leclercia adecarboxylata From China [PDF]

Frontiers in Microbiology, 2015
Raoultella ornithinolytica YNKP001 and Leclercia adecarboxylata P10164, harboring conjugative plasmids pYNKP001-NDM and pP10164-NDM with determination of complete nucleotide sequences, respectively, were isolated from two different Chinese patients ...
Fengjun Sun, Peiyuan Xia, Dongsheng Zhou
exaly   +4 more sources

PHT427 as an effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor restored the susceptibility of meropenem against Enterobacteriaceae producing NDM-1 [PDF]

Frontiers in Microbiology, 2023
IntroductionWith the increasingly serious problem of bacterial drug resistance caused by NDM-1, it is an important strategy to find effective inhibitors to assist β-lactam antibiotic treatment against NDM-1 resistant bacteria.
Xiaohui Li, Qian Wang, Ji Zheng, Ji Zheng, Yan Guan, Chennan Liu, Jiangxue Han, Sihan Liu, Tianjun Liu, Chunling Xiao, Xiao Wang, Yishuang Liu   +11 more
doaj   +2 more sources

In Silico Evaluation of Potential NDM-1 Inhibitors: An Integrated Docking and Molecular Dynamics Approach [PDF]

Pharmaceuticals
Background/Objectives: Non-fermenting Gram-negative bacteria are resistant to most antibiotics, due to the production of enzymes such as NDM-1. Faced with this challenge, computational methods have become essential for the design of NDM-1 carbapenemase ...
Eduvan Valencia, Mauricio Galvis, Jorge Nisperuza, Vladimir Ballesteros, Fredy Mesa   +4 more
doaj   +3 more sources

Molecular Characterization and Comparison of Bla NDM-1-Carrying and Bla NDM-5-Harboring IncX3-Type Plasmids in Carbapenem-Resistant Klebsiella pneumoniae.

Microbiology Spectrum, 2023
Carbapenem-resistant Klebsiella pneumoniae (CRKP), which harbors the bla NDM plasmid, has been reported extensively and is considered a global threat clinically.
Yunxing Yang, Darong Duan, Longjie Zhou
exaly   +3 more sources

The Transferability and Evolution of NDM-1 and KPC-2 Co-Producing Klebsiella pneumoniae From Clinical Settings

EBioMedicine, 2020
Background: Emergence of KPC-2 and NDM-1-coproducing carbapenem-resistant Klebsiella pneumoniae (KPC-2-NDM-1-CRKP) has escalated threat of CRKP to healthcare. Currently, only 4 isolates had been reported sporadically.
Longyang Jin, Hua Gao
exaly   +3 more sources

NDM-1 plasmid clustering reflects clonal transmission of Klebsiella pneumoniae ST147 in four hospitals in Berlin, Germany [PDF]

Antimicrobial Resistance and Infection Control
Background In recent years, the detection of Klebsiella pneumoniae (KLPN) producing New Delhi metallo-β-lactamase (NDM), particularly NDM-1, has increased in Germany.
Anna Weber, Luisa Denkel, Christine Geffers, Axel Kola, Friederike Maechler   +4 more
doaj   +2 more sources

Emergence of bla NDM−1 in Pseudomonas aeruginosa ST308 and ST773 from bloodstream infections in Egypt [PDF]

BMC Microbiology
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) remains a significant challenge to clinical management, particularly in critically ill hospitalized patients. The present study aimed to investigate the prevalence and molecular epidemiology of bla NDM-1
Asmaa AbdulHak, Hamdallah H. Zedan, Hadir A. El-Mahallawy, Ahmed A Sayed, Mai M. Zafer   +4 more
doaj   +2 more sources

Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma

Life Science Alliance, 2023
This pan-genomic study of crosstalk between HIF and AHR transcription factors reveals both antagonistic and cooperative interactions and highlights their relevance to kidney cancer and its treatment.
Véronique N Lafleur, Silvia Halim, Hani Choudhry, Peter J Ratcliffe, David R Mole   +4 more
doaj   +1 more source

Evolution of carbapenem resistance in klebsiella pneumoniae and escherichia coli carrying bla NDM−1 gene: imipenem exposure results in sustained resistance memory of strains in vitro

Annals of Clinical Microbiology and Antimicrobials, 2023
Background Antibiotics exert an outstanding selective pressure on bacteria, forcing their chromosomal gene mutations and drug resistance genes to spread.
Qiong Zhao, Longhua Sha, Zhaomeng Wu, Lixue Meng, Feixiang Yang, Lingling Wu, Chunfang Yu, Hua Zhang, Jingdan Yu, Zhixiong Jin   +9 more
doaj   +1 more source