Results 21 to 30 of about 24,768 (218)

Characterization of an IncFII plasmid encoding NDM-1 from Escherichia coli ST131. [PDF]

PLoS ONE, 2012
BackgroundThe current spread of the gene encoding the metallo-ß-lactamase NDM-1 in Enterobacteriaceae is linked to a variety of surrounding genetic structures and plasmid scaffolds.MethodologyThe whole sequence of plasmid pGUE-NDM carrying the bla(NDM-1)
Rémy A Bonnin, Laurent Poirel, Alessandra Carattoli, Patrice Nordmann   +3 more
doaj   +1 more source

Inhibitor discovery of full-length New Delhi metallo-β-lactamase-1 (NDM-1). [PDF]

PLoS ONE, 2013
New Delhi metallo-β-lactmase-1 (NDM-1) has recently attracted extensive attention for its biological activities to catalyze the hydrolysis of almost all of β-lactam antibiotics.
Bingzheng Shen, Yan Yu, Hui Chen, Xin Cao, Xingzhen Lao, Yongliang Fang, Yun Shi, Jiao Chen, Heng Zheng   +8 more
doaj   +1 more source

NDM-1–ProducingKlebsiella pneumoniae, Croatia [PDF]

Emerging Infectious Diseases, 2012
Objectives: A K. pneumoniae strain, resistant to carbapenems, was isolated in May 2009, from a blood culture of a 40-years-old man, recovered in a surgical intensive care unit of the Clinical Hospital Center in Zagreb, Croatia.The patient had been transferred from another hospital of a neighbouring country after 5 days of hospitalization due to a car ...
MAZZARIOL, Annarita, Bosnjak Z., Ballarini P., Budimir A., Bedenic B., Kalenic S., CORNAGLIA, Giuseppe   +6 more
openaire   +3 more sources

Spectroscopic and Mechanistic Studies of Heterodimetallic Forms of Metallo-β-lactamase NDM-1 [PDF]

, 2014
In an effort to characterize the roles of each metal ion in metallo-β-lactamase NDM-1, heterodimetallic analogues (CoCo-, ZnCo-, and CoCd-) of the enzyme were generated and characterized. UV–vis, 1H NMR, EPR, and EXAFS spectroscopies were used to confirm
Alyssa Hetrick, Ambler R. P., Amy R. Marts, Ankudinov A. L., Badarau A., Banci L., Bebrone C., Bennett B., Bertini I., Bertini I., Bertini I., Bertini I., Bicknell R., Bienvenue D. L., Bonomo R. A., Breece R. M., Brian Bennett, Carfi A., Copick A. J., Cricco J. A., Crisp J., Crowder M. W., Crowder M. W., David L. Tierney, Dennison C., Dennison C., deSeny D., Docobo-Perez F., Docquier J. D., Doi Y., Donaire A., Donaire A., Drawz S. M., Fernandez C. O., Fisher J. F., Garcia-Saez I., Garmer D. R., Garrity J. D., Garrity J. D., González J. M., Griffin D. H., Hao Yang, Hawk M. J., Hernandez V., Hu Z., Huang C. C., Huntington K. M., Kim Y., King D., Koh T. H., Kumarasamy K. K., Li T., Lisa M. N., Livermore D. M., Llarrull L. I., Llarrull L. I., Mahesh Aitha, McManus-Munoz S., Michael W. Crowder, Momb J., Orellano E. G., Papp-Wallace K. M., Park H., Periyannan G., Piccioli M., Prescott J. M., Reid T. S., Renault J. P., Riley E. A., Saini A., Salgado J., Sharma N., Sharma N. P., Spencer J., Stamper C., Strynadka N. C. J., Thakur P. K., Thomas P. W., Thomas P. W., Tioni M. F., Toney J. H., Ullah J. H., Vila A. J., Vila A. J., Wang Z., Wang Z., Worthington R. J., Xu D., Yamaguchi Y., Yang H., Yong D., Yuan Q., Zhang H., Zheng B., Zhu K.   +94 more
core   +3 more sources

Identification of New Delhi metallo-β-lactamase 1 in Acinetobacter lwoffii of food animal origin. [PDF]

PLoS ONE, 2012
BackgroundTo investigate the presence of metallo-β-lactamase (MBL) genes and the genetic environment of the New Delhi metallo-β-lactamase gene bla(NDM-1) in bacteria of food animal origin.Methodology/principal findingsGram-negative bacteria with low ...
Yang Wang, Congming Wu, Qijing Zhang, Jing Qi, Hebing Liu, Yu Wang, Tao He, Licai Ma, Jing Lai, Zhangqi Shen, Yuqing Liu, Jianzhong Shen   +11 more
doaj   +1 more source

Kinetic Study of Laboratory Mutants of NDM-1 Metallo-beta-Lactamase and the Importance of an Isoleucine at Position 35. [PDF]

, 2016
peer reviewedTwo laboratory mutants of NDM-1 were generated by replacing the isoleucine at position 35 with threonine and serine residues: the NDM-1(I35T)and NDM-1(I35S)enzymes.
Amicosante, Gianfranco, Bottoni, Carlo, Celenza, Giuseppe, Colapietro, Martina, Galleni, Moreno, Kerff, Frédéric, Marcoccia, Francesca, Matagne, André, Mercuri, Paola, Perilli, Mariagrazia, Sabatini, Alessia   +10 more
core   +1 more source

Higher isolation of NDM-1 producing Acinetobacter baumannii from the sewage of the hospitals in Beijing. [PDF]

PLoS ONE, 2014
Multidrug resistant microbes present in the environment are a potential public health risk. In this study, we investigate the presence of New Delhi metallo-β-lactamase 1 (NDM-1) producing bacteria in the 99 water samples in Beijing City, including river ...
Chuanfu Zhang, Shaofu Qiu, Yong Wang, Lihua Qi, Rongzhang Hao, Xuelin Liu, Yun Shi, Xiaofeng Hu, Daizhi An, Zhenjun Li, Peng Li, Ligui Wang, Jiajun Cui, Pan Wang, Liuyu Huang, John D Klena, Hongbin Song   +16 more
doaj   +1 more source

Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates

Acta Pharmaceutica Sinica B, 2021
New Delhi metallo-β-lactamase-1 (NDM-1) is capable of hydrolyzing nearly all β-lactam antibiotics, posing an emerging threat to public health. There are currently less effective treatment options for treating NDM-1 positive “superbug”, and no promising ...
Bing Zhao, Xinhui Zhang, Tingting Yu, Ying Liu, Xiaoling Zhang, Yongfang Yao, Xuejian Feng, Hongmin Liu, Dequan Yu, Liying Ma, Shangshang Qin   +10 more
doaj   +1 more source

Membrane anchoring stabilizes and favors secretion of New Delhi metallo-β-lactamase [PDF]

, 2015
Carbapenems, 'last-resort' β-lactam antibiotics, are inactivated by zinc-dependent metallo-β-lactamases (MBLs). The host innate immune response withholds nutrient metal ions from microbial pathogens by releasing metal-chelating proteins such as ...
A Kovacs-Simon, A Rokney, Alejandro J Vila, B Johne, BD Corbin, C Rumbo, C Schwechheimer, C Zhang, CA Schneider, D King, Elizabeth M Nolan, G Fiorilli, G Patel, G Periyannan, Guillermo Bahr, HJ Bootsma, J Morán-Barrio, JE Irazoqui, JM Bomberger, JM González, JM González, K Hede, KH Choi, KP Haley, L Dortet, L Poirel, LB Randall, Lisandro J González, LJ González, M Cerasi, M Hernandez Valladares, M Hussain, M Park, MB Brophy, ME Kovach, MF Haurat, MI Hood, MR Meini, MS Aschtgen, MW Crowder, N Selevsek, NC Kesty, P Marchiaro, P Ravasi, PD Veith, PS Borra, R Gläser, R Kitagawa, Robert A Bonomo, S Devos, S Santos, S Tottey, S Wommer, TA Murphy, Toshiki G Nakashige, TR Walsh, TR Walsh, V Schaar, V Schaar, VG Pederick, X Chen, Y Kim, Y Luo, Z Hu   +63 more
core   +3 more sources

Emergence of NDM-1-Producing Enterobacteriaceae in Belgium [PDF]

Antimicrobial Agents and Chemotherapy, 2011
ABSTRACT Five multidrug-resistant nonclonally related Enterobacteriaceae isolates were recovered in Belgium in 2010 from three patients who had been hospitalized in Pakistan, Montenegro, and Serbia/Kosovo.
Bogaerts, Pierre, Bouchahrouf, Warda, Rezende de Castro, Roberta, Deplano, Ariane, Berhin, Catherine, Pierard, Denis, Denis, Olivier, Glupczynski, Youri   +7 more
openaire   +3 more sources