Results 11 to 20 of about 107,878,294 (207)
Identification and characterization of the first Escherichia coli strain carrying NDM-1 gene in China. [PDF]
PLoS ONE, 2013 New Delhi metallo-β-lactamase-1 (NDM-1), an acquired class B carbapenemase, is a significant clinical threat due to its extended hydrolysis of β-lactams including carbapenems.
Zhiyuan Liu +11 more
doaj +2 more sources
Characterization of an IncFII plasmid encoding NDM-1 from Escherichia coli ST131. [PDF]
PLoS ONE, 2012 BackgroundThe current spread of the gene encoding the metallo-ß-lactamase NDM-1 in Enterobacteriaceae is linked to a variety of surrounding genetic structures and plasmid scaffolds.MethodologyThe whole sequence of plasmid pGUE-NDM carrying the bla(NDM-1)
Rémy A Bonnin +3 more
doaj +2 more sources
Frontiers in Microbiology, 2023 Here, we characterized the first French NDM-9-producing Acinetobacter baumannii isolate. A. baumannii 13A297, which belonged to the STPas25 (international clone IC7), was highly resistant to β-lactams including cefiderocol (MIC >32 mg/L). Whole genome
Susie Gaillot +16 more
doaj +2 more sources
How To Detect NDM-1 Producers [PDF]
Journal of Clinical Microbiology, 2011 ABSTRACT Enterobacterial isolates expressing the carbapenemase NDM-1 are emerging worldwide. Twenty-seven NDM-1-positive isolates of worldwide origin were included in this study to identify these strains as not only pathogens but also colonizers of normal flora for infection control screening.
Nordmann, P. +4 more
openaire +4 more sources
Embelin Restores Carbapenem Efficacy against NDM-1-Positive Pathogens [PDF]
Frontiers in Microbiology, 2018 The emergence and spread of carbapenemase in Gram-negative pathogens poses an enormous threat to global public health. New Delhi metallo-β-lactamase-1 (NDM-1) inactivates nearly every class of β-lactam antibiotics, including carbapenem; however, there is
Nian-Zhi Ning +11 more
doaj +2 more sources
First identification of novel NDM carbapenemase, NDM-7, in Escherichia coli in France. [PDF]
PLoS ONE, 2013 BACKGROUND: The NDM-1 carbapenemase has been identified in 2008 in Enterobacteriaceae. Since then, several reports have emphasized its rapid dissemination throughout the world.
Gaelle Cuzon +2 more
doaj +2 more sources
Genetic basis of transmission of bla NDM-1 among foodborne Vibrio parahaemolyticus strains in China [PDF]
Applied Microbiology and BiotechnologyCarbapenem-resistant Vibrio parahaemolyticus has emerged and spread extensively in China, posing a substantial threat to food safety and human health. This study investigated the prevalence of carbapenem resistance in V.
Dan Chen +8 more
doaj +2 more sources
Structural role of K224 in taniborbactam inhibition of NDM-1
Antimicrobial Agents and ChemotherapyABSTRACT Taniborbactam (TAN; VNRX-5133) is a novel bicyclic boronic acid β-lactamase inhibitor (BLI) being developed in combination with cefepime (FEP). TAN inhibits both serine and some metallo-β-lactamases. Previously, the substitution R228L in VIM-24 was shown to increase activity against oxyimino-cephalosporins like FEP and ...
Daisuke Ono +7 more
openaire +4 more sources
The directed evolution of NDM-1. [PDF]
Antimicrob Agents Chemother, 2023 ABSTRACT β-Lactam antibiotics are among the most frequently prescribed therapeutic agents. A common mechanism of resistance toward β-lactam antibiotics is the production of β-lactamases. These enzymes are capable of hydrolyzing the β-lactam bond, rendering the drug inactive.
Thomas CA +8 more
europepmc +3 more sources
Molecular basis of NDM-1, a new antibiotic resistance determinant. [PDF]
PLoS ONE, 2011 The New Delhi Metallo-β-lactamase (NDM-1) was first reported in 2009 in a Swedish patient. A recent study reported that Klebsiella pneumonia NDM-1 positive strain or Escherichia coli NDM-1 positive strain was highly resistant to all antibiotics tested ...
Zhongjie Liang +14 more
doaj +1 more source