Results 11 to 20 of about 24,768 (218)

Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma

Life Science Alliance, 2023
This pan-genomic study of crosstalk between HIF and AHR transcription factors reveals both antagonistic and cooperative interactions and highlights their relevance to kidney cancer and its treatment.
Véronique N Lafleur, Silvia Halim, Hani Choudhry, Peter J Ratcliffe, David R Mole   +4 more
doaj   +1 more source

Molecular characterization and comparison of bla NDM-1-carrying and bla NDM-5-harboring IncX3-type plasmids in carbapenem-resistant Klebsiella pneumoniae

Microbiology Spectrum, 2023
Carbapenem-resistant Klebsiella pneumoniae (CRKP), which harbors the bla NDM plasmid, has been reported extensively and is considered a global threat clinically.
Yunxing Yang, Haiyang Liu, Lingxia Chen, Minjie Mao, Xiaofan Zhang, Longjie Zhou, Darong Duan, Xi Li, Hua Zhou   +8 more
doaj   +1 more source

PHT427 as an effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor restored the susceptibility of meropenem against Enterobacteriaceae producing NDM-1

Frontiers in Microbiology, 2023
IntroductionWith the increasingly serious problem of bacterial drug resistance caused by NDM-1, it is an important strategy to find effective inhibitors to assist β-lactam antibiotic treatment against NDM-1 resistant bacteria.
Xiaohui Li, Qian Wang, Ji Zheng, Ji Zheng, Yan Guan, Chennan Liu, Jiangxue Han, Sihan Liu, Tianjun Liu, Chunling Xiao, Xiao Wang, Yishuang Liu   +11 more
doaj   +1 more source

Genomic characterization of an NDM-9-producing Acinetobacter baumannii clinical isolate and role of Glu152Lys substitution in the enhanced cefiderocol hydrolysis of NDM-9

Frontiers in Microbiology, 2023
Here, we characterized the first French NDM-9-producing Acinetobacter baumannii isolate. A. baumannii 13A297, which belonged to the STPas25 (international clone IC7), was highly resistant to β-lactams including cefiderocol (MIC >32 mg/L). Whole genome
Susie Gaillot, Saoussen Oueslati, Jean-Baptiste Vuillemenot, Jean-Baptiste Vuillemenot, Maxime Bour, Bogdan I. Iorga, Pauline Triponney, Patrick Plésiat, Patrick Plésiat, Rémy A. Bonnin, Rémy A. Bonnin, Thierry Naas, Thierry Naas, Katy Jeannot, Katy Jeannot, Anaïs Potron, Anaïs Potron   +16 more
doaj   +1 more source

Evolution of carbapenem resistance in klebsiella pneumoniae and escherichia coli carrying bla NDM−1 gene: imipenem exposure results in sustained resistance memory of strains in vitro

Annals of Clinical Microbiology and Antimicrobials, 2023
Background Antibiotics exert an outstanding selective pressure on bacteria, forcing their chromosomal gene mutations and drug resistance genes to spread.
Qiong Zhao, Longhua Sha, Zhaomeng Wu, Lixue Meng, Feixiang Yang, Lingling Wu, Chunfang Yu, Hua Zhang, Jingdan Yu, Zhixiong Jin   +9 more
doaj   +1 more source

How To Detect NDM-1 Producers [PDF]

Journal of Clinical Microbiology, 2011
ABSTRACT Enterobacterial isolates expressing the carbapenemase NDM-1 are emerging worldwide. Twenty-seven NDM-1-positive isolates of worldwide origin were included in this study to identify these strains as not only pathogens but also colonizers of normal flora for infection control screening.
Nordmann, P., Poirel, L., Carrer, A., Toleman, M. A., Walsh, T. R.   +4 more
openaire   +2 more sources

Molecular basis of NDM-1, a new antibiotic resistance determinant. [PDF]

PLoS ONE, 2011
The New Delhi Metallo-β-lactamase (NDM-1) was first reported in 2009 in a Swedish patient. A recent study reported that Klebsiella pneumonia NDM-1 positive strain or Escherichia coli NDM-1 positive strain was highly resistant to all antibiotics tested ...
Zhongjie Liang, Lianchun Li, Yuanyuan Wang, Limin Chen, Xiangqian Kong, Yao Hong, Lefu Lan, Mingyue Zheng, Cai Guang-Yang, Hong Liu, Xu Shen, Cheng Luo, Keqin Kathy Li, Kaixian Chen, Hualiang Jiang   +14 more
doaj   +1 more source

Identification and characterization of the first Escherichia coli strain carrying NDM-1 gene in China. [PDF]

PLoS ONE, 2013
New Delhi metallo-β-lactamase-1 (NDM-1), an acquired class B carbapenemase, is a significant clinical threat due to its extended hydrolysis of β-lactams including carbapenems.
Zhiyuan Liu, Wei Li, Jie Wang, Jian Pan, Shipeng Sun, Yanhua Yu, Bing Zhao, Yuzhi Ma, Tingju Zhang, Jie Qi, Guijian Liu, Fengmin Lu   +11 more
doaj   +1 more source

Successful Treatment of Acute Prostatitis Caused by Multidrug-Resistant Escherichia coli With Tigecycline Monotherapy [PDF]

, 2020
We present a successful treatment, with tigecycline monotherapy, of acute prostatitis caused by multidrug-resistant Escherichia coli harboring an NDM-1 carbapemenase along with a CMY-2 cephalosporinase and a TEM ...
Babouee Flury, Baharak, Buetti, Niccolo, Casanova, Carlo, Furrer, Hansjakob, Jent, Philipp, Livermore, David M, Lo Priore, Elia, Pelzer, Niklas   +7 more
core   +2 more sources

Specific NDM-1 Inhibitor of Isoliquiritin Enhances the Activity of Meropenem against NDM-1-positive Enterobacteriaceae in vitro [PDF]

International Journal of Environmental Research and Public Health, 2020
NDM-1-positive Enterobacteriaceae have caused serious clinical infections, with high mortality rates. Carbapenem was the ultimate expectation for the treatment of such infections in clinical practice. However, since the discovery of plasmid-mediated New Delhi metallo-β-lactamase-1 (NDM-1), the efficient therapeutic effects of carbapenems have been ...
Yanling Wang, Xiaodi Sun, Fanrong Kong, Lining Xia, Xuming Deng, Dacheng Wang, Jianfeng Wang   +6 more
openaire   +2 more sources