Results 101 to 110 of about 107,878,294 (207)

Insights from modeling the 3D structure of New Delhi metallo-β-lactamse and its binding interactions with antibiotic drugs.

PLoS ONE, 2011
New Delhi metallo-beta-lactamase (NDM-1) is an enzyme that makes bacteria resistant to a broad range of beta-lactam antibiotic drugs. This is because it can inactivate most beta-lactam antibiotic drugs by hydrolyzing them.
Jing-Fang Wang, Kuo-Chen Chou
doaj   +1 more source

Molecular characterisation of the NDM-1-encoding plasmid p2189-NDM in an Escherichia coli ST410 clinical isolate from Ghana

, 2018
Global dissemination of New Delhi metallo-β-lactamase (NDM)-producing bacteria has become a major health threat. However, there are few reports regarding the identification and characterisation of NDM-producing bacteria from West Africa, including Ghana.
Wakana Sato, Isaac Prah, Mitsuko Ohashi (6111626), Samiratu Mahazu (6111620), Toshihiko Suzuki (78077), Ryoichi Saito, John Addow-Thompson (6111623), Anthony Ablordey (144930), Wakana Sato (6111617), Toshihiko Suzuki, Isaac Prah (690638), Samiratu Mahazu, John Addow-Thompson, Shiroh Iwanaga, Alafate Ayibieke, Alafate Ayibieke (6111614), Shiroh Iwanaga (121019), Mitsuko Ohashi, Anthony Ablordey, Ryoichi Saito (2261854)   +19 more
core   +1 more source

Effects of the pH, temperature, and EDTA on NDM-1.

, 2013
A: pH dependence of NDM-1 at 25°C. The enzyme was incubated in buffers with various pH values for 20 min at 30°C before assaying with 0.5 mM meropenem as a substrate. Averages are reported based on three independent measurements.
Sen Luo (402165), Dehui Wang (402167), Xiang Li (114679), Qin Wang (109812), Hui Wang (30400), Fanghong Chen (402164), Zhan Li (402168), Tao Li (86810), Huali Fang (402166), Xiaojun Hou (402169)   +9 more
core   +1 more source

Cefiderocol-Based Regimen for Acinetobacter NDM-1 Outbreak. [PDF]

Antibiotics (Basel)
Variable outcomes have been reported with cefiderocol in infections due to carbapenem-resistant Acinetobacter baumannii (CRAB). Nonetheless, it may be the only option for metallo-beta-lactamase-producing strains. We describe an outbreak of NDM-CRAB infections treated with cefiderocol. Thirty-eight patients were colonized and/or infected.
Travi G, Peracchi F, Merli M, Lo Re N, Matarazzo E, Tartaglione L, Bielli A, Casalicchio G, Crippa F, Vismara CS, Puoti M.   +10 more
europepmc   +4 more sources

The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase

Nature Communications, 2019
The NDM-1 metallo-β-lactamase confers resistance to β-lactam antibiotics. Here, the authors show that the antimicrobial peptide thanatin is active against NDM-1-producing bacteria through a dual mechanism of action consisting of disruption of outer ...
Bo Ma, Chao Fang, Linshan Lu, Mingzhi Wang, Xiaoyan Xue, Ying Zhou, Mingkai Li, Yue Hu, Xiaoxing Luo, Zheng Hou   +9 more
doaj   +1 more source

Coomassie blue stained 12% SDS-PAGE of purified NDM-1.

, 2013
The highly purified and soluble NDM-1 is shown. The molecular weight of NDM-1 is approximately 28 kDa.
Sen Luo (402165), Dehui Wang (402167), Xiang Li (114679), Qin Wang (109812), Hui Wang (30400), Fanghong Chen (402164), Zhan Li (402168), Tao Li (86810), Huali Fang (402166), Xiaojun Hou (402169)   +9 more
core   +1 more source

Emergence of Various NDM-Type-Metallo-β-Lactamase-Producing Escherichia coli Clinical Isolates in Nepal

, 2017
Of 250 clinical isolates of Escherichia coli obtained in Nepal, 38 were carbapenem resistant, with MICs of imipenem or meropenem of ≥4 μg/ml. All 38 isolates harbored the following bla NDM s:
Bharat Mani Pokhrel, Kayo Shimada, Teruo Kirikae, Tatsuya Tada, Shovita Shrestha, Hiroshi Ohara, Jeevan B. Sherchand, Basudha Shrestha   +7 more
core   +1 more source

First Report of NDM-1-Producing Acinetobacter guillouiae. [PDF]

Chemotherapy, 2014
Acinetobacter spp. is an opportunistic pathogen that has demonstrated increasing relevance in nosocomial infections. Carbapenem-resistant strains have been reported worldwide.Since 2014, screening for metallo-β-lactamases (MBLs) in all Acinetobacter spp.
Bošnjak, Zrinka, Plečko, Vanda, Budimir, Ana, Mareković, Ivana, Bedenić, Branka   +4 more
openaire   +4 more sources

Aztreonam Competitively Inhibits Hydrolysis of β-Lactam Antibiotics by NDM-1

, 2019
We investigated the effect of Aztreonam on hydrolysis of β-lactam antibiotics by MBL using New Delhi Metallo-β-lactamase-1(NDM-1) as a model. The results showed that Aztreonam significantly inhibited hydrolysis of Nitrocefin and Meropenem by soluble NDM ...
Li, Shenwei,, Meng, Qinglai,, Zhang, Sheng,, Xie, Bin,, Wang, Xi,, Li, Binchun,, Lund University., Wu, Changxin,   +7 more
core  

First detection in Spain of NDM-1-producing Pseudomonas aeruginosa in two patients transferred from Ukraine to a university hospital

Journal of Global Antimicrobial Resistance
Objectives: Carbapenemase-mediated carbapenem resistance in Pseudomonas aeruginosa is a relevant health problem. We detected for the first time in Spain two clinical NDM-producing P.
Marta Hernández-García, Margarita Cabello, Manuel Ponce-Alonso, Pedro M. Herrador-Gómez, Francesca Gioia, Javier Cobo, Rafael Cantón, Patricia Ruiz-Garbajosa   +7 more
doaj   +1 more source