Results 221 to 230 of about 63,496 (250)

The directed evolution of NDM-1

Antimicrobial Agents and Chemotherapy, 2023
ABSTRACT β-Lactam antibiotics are among the most frequently prescribed therapeutic agents. A common mechanism of resistance toward β-lactam antibiotics is the production of β-lactamases. These enzymes are capable of hydrolyzing the β-lactam bond, rendering the drug inactive.
Caitlyn A. Thomas, Zishuo Cheng, Christopher R. Bethel, Andrea M. Hujer, Aidan M. Sturgill, Kelechi Onuoha, Richard C. Page, Robert A. Bonomo, Michael W. Crowder   +8 more
openaire   +2 more sources

Treatment strategies for OXA-48-like and NDM producing Klebsiella pneumoniae infections

Expert Review of Anti-Infective Therapy, 2022
Introduction OXA-48 and NDM are amongst the most prevalent carbapenemase types associated with Klebsiella pneumoniae worldwide, with an increase in their prevalence in recent years. Knowledge on the treatment of carbapenem-resistant Klebsiella pneumoniae
B. Isler, A. Aslan, M. Akova, P. Harris, D. Paterson   +4 more
semanticscholar   +1 more source

The emerging NDM carbapenemases

Trends in Microbiology, 2011
Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian
Nordmann, Patrice, Poirel, Laurent, Walsh, Timothy R, Livermore, David M   +3 more
openaire   +3 more sources

Molecular Diversity of NDM-1, NDM-5, NDM-6, and NDM-7 Variants of New Delhi Metallo-β-Lactamases and Their Impact on Drug Resistance

Clinical Laboratory, 2021
The emergence of multidrug-resistant bacteria has become a serious healthcare problem worldwide.In this study, 192 clinical specimens collected from a tertiary hospital in Al Jouf, Saudi Arabia were processed in order to isolate gram-negative bacteria.
openaire   +2 more sources

Detection of carbapenem-resistant hypervirulent Klebsiella pneumoniae ST11-K64 co-producing NDM-1 and KPC-2 in a Tertiary Hospital in Wuhan.

Journal of Hospital Infection, 2022
BACKGROUND Carbapenem-resistant hypervirulent K. pneumoniae (CR-hvKP) poses serious challenges to public health. Until now, only a few sporadic reports of strains co-producing NDM-1 and KPC-2 (NDM-1-KPC-2-CR-hvKP) are available.
Yun Huang, Juan Li, Qianyu Wang, Kewen Tang Xuan Cai, Congrong Li   +4 more
semanticscholar   +1 more source

Prevalence and molecular characterisation of New Delhi metallo-β-lactamases NDM-1, NDM-5, NDM-6 and NDM-7 in multidrug-resistant Enterobacteriaceae from India

International Journal of Antimicrobial Agents, 2014
The growing prevalence of carbapenem resistance in Enterobacteriaceae worldwide is a major concern. New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance has been identified in Enterobacteriaceae from numerous countries including those of the Indian subcontinent. Currently, seven NDM β-lactamase variants (NDM-1 to -7) have been identified.
Mohibur, Rahman, Sanket Kumar, Shukla, Kashi Nath, Prasad, Cristina M, Ovejero, Binod Kumar, Pati, Aparna, Tripathi, Avinash, Singh, Ashwini K, Srivastava, Bruno, Gonzalez-Zorn   +8 more
openaire   +2 more sources

Metallo-β-lactamases inhibitor fisetin attenuates meropenem resistance in NDM-1-producing Escherichia coli.

European journal of medicinal chemistry, 2022
The prevalence and development of New Delhi metallo-β-lactamase-1 (NDM-1) have led to increases in bacterial resistance to the majority of clinically used antibiotics, including carbapenems.
Yan Guo, Yanan Yang, Xiangzhu Xu, Li Li, Yong-lin Zhou, Guo-Song Jia, Lijuan Wei, Qinlei Yu, Jianfeng Wang   +8 more
semanticscholar   +1 more source

Wide distribution of Escherichia coli carrying IncF plasmids containing bla NDM-5 and rmtB resistance genes from hospitalized patients in England.

Journal of Medical Microbiology, 2022
Introduction. The New Delhi metallo-β-lactamase (NDM) variant NDM-5 was first described in 2011 in an isolate of Escherichia coli. We noted that a high proportion of isolates of E.
J. Turton, R. Pike, C. Perry, C. Jenkins, Jack A. Turton, D. Meunier, K. Hopkins   +6 more
semanticscholar   +1 more source

Rapid emergence, transmission, and evolution of KPC and NDM coproducing carbapenem-resistant Klebsiella pneumoniae.

Microbiology Research
Due to the limited treatment options, the widespread of carbapenem-resistant Klebsiella pneumoniae (CRKP) has become a serious clinical challenge.
Jiayang Li, Wenqi Wu, Hao Wu, Jinjian Huang, Ze Li, Jiajie Wang, Zhitao Zhou, Meilin Wu, Xiuwen Wu, Yun Zhao, Jianan Ren   +10 more
semanticscholar   +1 more source

Balkan NDM-1: escape or transplant?

The Lancet Infectious Diseases, 2011
164 www.thelancet.com/infection Vol 11 March 2011 4 Sadetzki S, Chetrit A, Lubina A, et al. Risk of thyroid cancer after childhood exposure to ionizing radiation for tinea capitis. J Clin Endocrinol Metab 2006; 91: 4798–04. 5 Boaventura P, Bastos J, Pereira D, et al.
Livermore, David M., Walsh, Timothy R., Toleman, Mark, Woodford, Neil   +3 more
openaire   +2 more sources