Results 231 to 240 of about 63,496 (250)

NDM-1 polymicrobial infections including Vibrio cholerae

The Lancet, 2012
In April, 2011, a 49-year-old British man was admitted to our hospital directly from a fl ight home from India. He presented with extensive electrical burns on his face, neck, left arm, leg, soles, and chest, from an accident in a faulty shower 4 days before while in Bihar, India.
Elizabeth, Darley, Janis, Weeks, Lim, Jones, Victoria, Daniels, Mandy, Wootton, Alasdair, MacGowan, Timothy, Walsh   +6 more
openaire   +2 more sources

Simplified captopril analogues as NDM-1 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2014
Captopril is a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 value of 7.9μM. It is composed of two units: a 3-mercapto-2-methylpropanoyl fragment and a proline residue. In this study, we synthesized simple amide derivatives of 3-mercapto-2-methylpropanoic acid, and then tested them as NDM-1 inhibitors in order to identify the ...
Ningning, Li, Yintong, Xu, Qiang, Xia, Cuigai, Bai, Taiyi, Wang, Lei, Wang, Dingdi, He, Nannan, Xie, Lixin, Li, Jing, Wang, Hong-Gang, Zhou, Feng, Xu, Cheng, Yang, Quan, Zhang, Zheng, Yin, Yu, Guo, Yue, Chen   +16 more
openaire   +2 more sources

NDM-1 — A Cause for Worldwide Concern

New England Journal of Medicine, 2010
NDM-1 (New Delhi metallo-beta-lactamase 1), a genetic element encoding multiple-resistance genes, has been found in various Enterobacteriaceae, rendering them resistant to nearly all antimicrobial agents. Success in combating antibiotic-resistant superbugs has been limited.
openaire   +2 more sources

Evolutionary insights into NDM variants: Identification and functional analysis of novel NDM-58 in Pseudomonas aeruginosa

Microbial Pathogenesis
The emergence of New Delhi Metallo-β-lactamase (NDM) variants in P. aeruginosa has significantly contributed to carbapenem resistance, posing a global threat to antimicrobial therapy. The catalytic activity of NDM, dependent on Zn (II), is enhanced by specific mutations. In this study, we report the identification and characterization of a novel NDM-58
Maruthan, Karthik, Nagesh Kishan, Panchal, Monisha, T, Yamuna Devi, Bakthavatchalam, Ayyanraj, Neeravi, Baby, Abirami, Kamini, Walia, Balaji, Veeraraghavan   +7 more
openaire   +2 more sources

Recent research and development of NDM-1 inhibitors.

European journal of medicinal chemistry, 2021
Ting Wang, Kaiju Xu, Liyun Zhao, Rongsheng Tong, L. Xiong, Jianyou Shi   +5 more
semanticscholar   +1 more source

SP23-3 Characterization of NDM-1

International Journal of Antimicrobial Agents, 2013
indicated that the strain NDM-1-Saitama belonged to sequence type ST42 which had not been reported previously. Complete sequencing and gap closing by PCR demonstrated a 49,441bp IncFII plasmid which bears 53 genes. The plasmid pNDM-1Saitama consists of 22kb backbone and 27kb multi-drug resistant region. Half of the backbone showed 100% perfect match of
openaire   +1 more source

NDM-1

Nursing, 2012
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Dissemination of NDM-1 – Authors' reply

The Lancet Infectious Diseases, 2012
Walsh, Timothy R, Livermore, David M, Weeks, Janis, Toleman, Mark A   +3 more
openaire   +1 more source

Efforts towards the inhibitor design for New Delhi metallo-beta-lactamase (NDM-1).

European journal of medicinal chemistry, 2021
K. N. Nagulapalli Venkata, Morgan D. Ellebrecht, S. Tripathi   +2 more
semanticscholar   +1 more source

β-Lactam Resistance Gene NDM-1 in the Aquatic Environment: A Review

Current Microbiology, 2021
R. Ranjan, Shashidhar Thatikonda
semanticscholar   +1 more source