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A protective variant of the autophagy receptor CALCOCO2/NDP52 in Multiple Sclerosis (MS)
Autophagy, 2021Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, which has been found associated with dysfunctional mitochondria. In order to advance our understanding of the complex molecular mechanisms underlying this disease, we analyzed mitophagy, a process fundamental for the elimination of damaged mitochondria through the ...
Anthea, Di Rita, Flavie, Strappazzon
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Novel Insights into NDP52 Autophagy Receptor Functioning
Trends in Cell Biology, 2018NDP52/CALCOCO2 makes multiple contributions to selective autophagy. By interacting with cargos and LC3, NDP52 directs autophagy targets to autophagosomes. In addition, NDP52 promotes autophagosomes fusion with endolysosomes by connecting autophagosomes to MYOSIN VI.
Viret, Christophe +2 more
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Autophagy receptor CALCOCO2/NDP52 takes center stage in Crohn disease [PDF]
Autophagy, 2013 To advance understanding of the complex genetics of Crohn disease (CD) we sequenced 42 whole exomes of patients with CD and five healthy control individuals, resulting in identification of a missense mutation in the autophagy receptor calcium binding and coiled-coil domain 2 (CALCOCO2/NDP52) gene.
Andreas Till +2 more
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Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52 [PDF]
Nature Communications, 2014 Nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal transcription factor in the defence against oxidative stress. Here we provide evidence that activation of the Nrf2 pathway reduces the levels of phosphorylated tau by induction of an autophagy adaptor protein NDP52 (also known as CALCOCO2) in neurons. The expression of NDP52, which we show
Soner Gundemir +2 more
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Nature Immunology, 2009
Cell-autonomous innate immune responses against bacteria attempting to colonize the cytosol of mammalian cells are incompletely understood. Polyubiquitylated proteins can accumulate on the surface of such bacteria, and bacterial growth is restricted by Tank-binding kinase (TBK1).
TERESA L M Thurston +2 more
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Cell-autonomous innate immune responses against bacteria attempting to colonize the cytosol of mammalian cells are incompletely understood. Polyubiquitylated proteins can accumulate on the surface of such bacteria, and bacterial growth is restricted by Tank-binding kinase (TBK1).
TERESA L M Thurston +2 more
exaly +3 more sources
CALCOCO2/NDP52 initiates selective autophagy through recruitment of ULK and TBK1 kinase complexes [PDF]
Autophagy, 2019 The selective macroautophagy of prospective cargo necessitates activity of the autophagy machinery at cargo-determined locations. Whether phagophore membranes are recruited to, or are generated de novo at, the cargo is unknown. In our recent study we show that damaged Salmonella-containing vacuoles, marked by LGALS8/galectin-8, engage the cargo ...
Keith B Boyle, Felix Randow
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NDP52 associates with phosphorylated tau in brains of an Alzheimer disease mouse model
Biochemical and Biophysical Research Communications, 2014We previously showed that NDP52 (also known as calcoco2) plays a role as an autophagic receptor for phosphorylated tau facilitating its clearance via autophagy. Here, we examined the expression and association of NDP52 with autophagy-regulated gene (ATG) proteins including LC3, as well as phosphorylated tau and amyloid-beta (Aβ) in brains of an AD ...
Sunhyo Kim +8 more
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NDP52 inhibition rescues cigarette smoke mediated impairment of autophagy in macrophages
3.2 Airway Cell Biology and Immunopathology, 2016Introduction: Autophagy is a process that maintains intracellular homeostasis by degrading unwanted proteins, protein aggregates, dysfunctional organelles and pathogens. The role of autophagy in the pathogenesis of COPD is not well understood. NDP52 is an autophagic adaptor protein which binds intracellular pathogens for autophagy-mediated clearance ...
Yuta Kono +4 more
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NDP52 acts as a redox sensor in PINK1/Parkin‐mediated mitophagy
EMBO Journal, 2023Tetsushi Kataura +2 more
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